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P0A9H5

- BTUR_ECOLI

UniProt

P0A9H5 - BTUR_ECOLI

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Protein
Cob(I)yrinic acid a,c-diamide adenosyltransferase
Gene
btuR, cobA, b1270, JW1262
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids By similarity.

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 427ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: EcoCyc

GO - Biological processi

  1. aerobic cobalamin biosynthetic process Source: EcoCyc
  2. cobalamin biosynthetic process Source: EcoCyc
  3. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cobalamin biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:COBALADENOSYLTRANS-MONOMER.
ECOL316407:JW1262-MONOMER.
UniPathwayiUPA00148; UER00233.

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Corrinoid adenosyltransferase
Gene namesi
Name:btuR
Synonyms:cobA
Ordered Locus Names:b1270, JW1262
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10130. btuR.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Cob(I)yrinic acid a,c-diamide adenosyltransferase
PRO_0000065009Add
BLAST

Proteomic databases

PaxDbiP0A9H5.
PRIDEiP0A9H5.

Expressioni

Gene expression databases

GenevestigatoriP0A9H5.

Interactioni

Protein-protein interaction databases

IntActiP0A9H5. 14 interactions.
STRINGi511145.b1270.

Structurei

3D structure databases

ProteinModelPortaliP0A9H5.
SMRiP0A9H5. Positions 28-196.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2109.
HOGENOMiHOG000260311.
KOiK00798.
OMAiPVKHAFE.
OrthoDBiEOG6GN76J.
PhylomeDBiP0A9H5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
IPR025826. Co_AT_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF12557. Co_AT_N. 1 hit.
PF02572. CobA_CobO_BtuR. 1 hit.
[Graphical view]
PIRSFiPIRSF015617. Adensltrnsf_CobA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00708. cobA. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A9H5-1 [UniParc]FASTAAdd to Basket

« Hide

MSDERYQQRQ QRVKEKVDAR VAQAQDERGI IIVFTGNGKG KTTAAFGTAT    50
RAVGHGKKVG VVQFIKGTWP NGERNLLEPH GVEFQVMATG FTWDTQNRES 100
DTAACREVWQ HAKRMLADSS LDMVLLDELT YMVAYDYLPL EEVVQALNER 150
PHQQTVIITG RGCHRDILEL ADTVSELRPV KHAFDAGVKA QIGIDY 196
Length:196
Mass (Da):21,999
Last modified:July 19, 2005 - v1
Checksum:i4EE2FDD9C74FE8AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21528 Genomic DNA. Translation: AAA23530.1.
U00096 Genomic DNA. Translation: AAC74352.1.
AP009048 Genomic DNA. Translation: BAA14807.1.
PIRiA64875.
RefSeqiNP_415786.1. NC_000913.3.
YP_489538.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74352; AAC74352; b1270.
BAA14807; BAA14807; BAA14807.
GeneIDi12930581.
945839.
KEGGiecj:Y75_p1244.
eco:b1270.
PATRICi32117798. VBIEscCol129921_1319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21528 Genomic DNA. Translation: AAA23530.1 .
U00096 Genomic DNA. Translation: AAC74352.1 .
AP009048 Genomic DNA. Translation: BAA14807.1 .
PIRi A64875.
RefSeqi NP_415786.1. NC_000913.3.
YP_489538.1. NC_007779.1.

3D structure databases

ProteinModelPortali P0A9H5.
SMRi P0A9H5. Positions 28-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P0A9H5. 14 interactions.
STRINGi 511145.b1270.

Proteomic databases

PaxDbi P0A9H5.
PRIDEi P0A9H5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74352 ; AAC74352 ; b1270 .
BAA14807 ; BAA14807 ; BAA14807 .
GeneIDi 12930581.
945839.
KEGGi ecj:Y75_p1244.
eco:b1270.
PATRICi 32117798. VBIEscCol129921_1319.

Organism-specific databases

EchoBASEi EB0128.
EcoGenei EG10130. btuR.

Phylogenomic databases

eggNOGi COG2109.
HOGENOMi HOG000260311.
KOi K00798.
OMAi PVKHAFE.
OrthoDBi EOG6GN76J.
PhylomeDBi P0A9H5.

Enzyme and pathway databases

UniPathwayi UPA00148 ; UER00233 .
BioCyci EcoCyc:COBALADENOSYLTRANS-MONOMER.
ECOL316407:JW1262-MONOMER.

Miscellaneous databases

PROi P0A9H5.

Gene expression databases

Genevestigatori P0A9H5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
IPR025826. Co_AT_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF12557. Co_AT_N. 1 hit.
PF02572. CobA_CobO_BtuR. 1 hit.
[Graphical view ]
PIRSFi PIRSF015617. Adensltrnsf_CobA. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00708. cobA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Altered cobalamin metabolism in Escherichia coli btuR mutants affects btuB gene regulation."
    Lundrigan M.D., Kadner R.J.
    J. Bacteriol. 171:154-161(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiBTUR_ECOLI
AccessioniPrimary (citable) accession number: P0A9H5
Secondary accession number(s): P13040
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3