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P0A9H5

- BTUR_ECOLI

UniProt

P0A9H5 - BTUR_ECOLI

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Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

btuR

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity).By similarity

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 427ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: EcoCyc

GO - Biological processi

  1. aerobic cobalamin biosynthetic process Source: EcoCyc
  2. cobalamin biosynthetic process Source: EcoCyc
  3. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cobalamin biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:COBALADENOSYLTRANS-MONOMER.
ECOL316407:JW1262-MONOMER.
UniPathwayiUPA00148; UER00233.

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Corrinoid adenosyltransferase
Gene namesi
Name:btuR
Synonyms:cobA
Ordered Locus Names:b1270, JW1262
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10130. btuR.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Cob(I)yrinic acid a,c-diamide adenosyltransferasePRO_0000065009Add
BLAST

Proteomic databases

PaxDbiP0A9H5.
PRIDEiP0A9H5.

Expressioni

Gene expression databases

GenevestigatoriP0A9H5.

Interactioni

Protein-protein interaction databases

IntActiP0A9H5. 14 interactions.
STRINGi511145.b1270.

Structurei

3D structure databases

ProteinModelPortaliP0A9H5.
SMRiP0A9H5. Positions 28-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2109.
HOGENOMiHOG000260311.
InParanoidiP0A9H5.
KOiK00798.
OMAiPVKHAFE.
OrthoDBiEOG6GN76J.
PhylomeDBiP0A9H5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
IPR025826. Co_AT_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF12557. Co_AT_N. 1 hit.
PF02572. CobA_CobO_BtuR. 1 hit.
[Graphical view]
PIRSFiPIRSF015617. Adensltrnsf_CobA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00708. cobA. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A9H5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDERYQQRQ QRVKEKVDAR VAQAQDERGI IIVFTGNGKG KTTAAFGTAT
60 70 80 90 100
RAVGHGKKVG VVQFIKGTWP NGERNLLEPH GVEFQVMATG FTWDTQNRES
110 120 130 140 150
DTAACREVWQ HAKRMLADSS LDMVLLDELT YMVAYDYLPL EEVVQALNER
160 170 180 190
PHQQTVIITG RGCHRDILEL ADTVSELRPV KHAFDAGVKA QIGIDY
Length:196
Mass (Da):21,999
Last modified:July 19, 2005 - v1
Checksum:i4EE2FDD9C74FE8AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21528 Genomic DNA. Translation: AAA23530.1.
U00096 Genomic DNA. Translation: AAC74352.1.
AP009048 Genomic DNA. Translation: BAA14807.1.
PIRiA64875.
RefSeqiNP_415786.1. NC_000913.3.
YP_489538.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC74352; AAC74352; b1270.
BAA14807; BAA14807; BAA14807.
GeneIDi12930581.
945839.
KEGGiecj:Y75_p1244.
eco:b1270.
PATRICi32117798. VBIEscCol129921_1319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21528 Genomic DNA. Translation: AAA23530.1 .
U00096 Genomic DNA. Translation: AAC74352.1 .
AP009048 Genomic DNA. Translation: BAA14807.1 .
PIRi A64875.
RefSeqi NP_415786.1. NC_000913.3.
YP_489538.1. NC_007779.1.

3D structure databases

ProteinModelPortali P0A9H5.
SMRi P0A9H5. Positions 28-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P0A9H5. 14 interactions.
STRINGi 511145.b1270.

Proteomic databases

PaxDbi P0A9H5.
PRIDEi P0A9H5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC74352 ; AAC74352 ; b1270 .
BAA14807 ; BAA14807 ; BAA14807 .
GeneIDi 12930581.
945839.
KEGGi ecj:Y75_p1244.
eco:b1270.
PATRICi 32117798. VBIEscCol129921_1319.

Organism-specific databases

EchoBASEi EB0128.
EcoGenei EG10130. btuR.

Phylogenomic databases

eggNOGi COG2109.
HOGENOMi HOG000260311.
InParanoidi P0A9H5.
KOi K00798.
OMAi PVKHAFE.
OrthoDBi EOG6GN76J.
PhylomeDBi P0A9H5.

Enzyme and pathway databases

UniPathwayi UPA00148 ; UER00233 .
BioCyci EcoCyc:COBALADENOSYLTRANS-MONOMER.
ECOL316407:JW1262-MONOMER.

Miscellaneous databases

PROi P0A9H5.

Gene expression databases

Genevestigatori P0A9H5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
IPR025826. Co_AT_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF12557. Co_AT_N. 1 hit.
PF02572. CobA_CobO_BtuR. 1 hit.
[Graphical view ]
PIRSFi PIRSF015617. Adensltrnsf_CobA. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00708. cobA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Altered cobalamin metabolism in Escherichia coli btuR mutants affects btuB gene regulation."
    Lundrigan M.D., Kadner R.J.
    J. Bacteriol. 171:154-161(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiBTUR_ECOLI
AccessioniPrimary (citable) accession number: P0A9H5
Secondary accession number(s): P13040
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3