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P0A9H5

- BTUR_ECOLI

UniProt

P0A9H5 - BTUR_ECOLI

Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

btuR

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids By similarity.By similarity

    Catalytic activityi

    ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
    ATP + cobinamide = triphosphate + adenosylcobinamide.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi36 – 427ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: EcoCyc

    GO - Biological processi

    1. aerobic cobalamin biosynthetic process Source: EcoCyc
    2. cobalamin biosynthetic process Source: EcoCyc
    3. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cobalamin biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:COBALADENOSYLTRANS-MONOMER.
    ECOL316407:JW1262-MONOMER.
    UniPathwayiUPA00148; UER00233.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
    Alternative name(s):
    Cob(I)alamin adenosyltransferase
    Corrinoid adenosyltransferase
    Gene namesi
    Name:btuR
    Synonyms:cobA
    Ordered Locus Names:b1270, JW1262
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG10130. btuR.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 196196Cob(I)yrinic acid a,c-diamide adenosyltransferasePRO_0000065009Add
    BLAST

    Proteomic databases

    PaxDbiP0A9H5.
    PRIDEiP0A9H5.

    Expressioni

    Gene expression databases

    GenevestigatoriP0A9H5.

    Interactioni

    Protein-protein interaction databases

    IntActiP0A9H5. 14 interactions.
    STRINGi511145.b1270.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A9H5.
    SMRiP0A9H5. Positions 28-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2109.
    HOGENOMiHOG000260311.
    KOiK00798.
    OMAiPVKHAFE.
    OrthoDBiEOG6GN76J.
    PhylomeDBiP0A9H5.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
    IPR025826. Co_AT_N_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF12557. Co_AT_N. 1 hit.
    PF02572. CobA_CobO_BtuR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015617. Adensltrnsf_CobA. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00708. cobA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A9H5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDERYQQRQ QRVKEKVDAR VAQAQDERGI IIVFTGNGKG KTTAAFGTAT    50
    RAVGHGKKVG VVQFIKGTWP NGERNLLEPH GVEFQVMATG FTWDTQNRES 100
    DTAACREVWQ HAKRMLADSS LDMVLLDELT YMVAYDYLPL EEVVQALNER 150
    PHQQTVIITG RGCHRDILEL ADTVSELRPV KHAFDAGVKA QIGIDY 196
    Length:196
    Mass (Da):21,999
    Last modified:July 19, 2005 - v1
    Checksum:i4EE2FDD9C74FE8AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21528 Genomic DNA. Translation: AAA23530.1.
    U00096 Genomic DNA. Translation: AAC74352.1.
    AP009048 Genomic DNA. Translation: BAA14807.1.
    PIRiA64875.
    RefSeqiNP_415786.1. NC_000913.3.
    YP_489538.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC74352; AAC74352; b1270.
    BAA14807; BAA14807; BAA14807.
    GeneIDi12930581.
    945839.
    KEGGiecj:Y75_p1244.
    eco:b1270.
    PATRICi32117798. VBIEscCol129921_1319.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21528 Genomic DNA. Translation: AAA23530.1 .
    U00096 Genomic DNA. Translation: AAC74352.1 .
    AP009048 Genomic DNA. Translation: BAA14807.1 .
    PIRi A64875.
    RefSeqi NP_415786.1. NC_000913.3.
    YP_489538.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0A9H5.
    SMRi P0A9H5. Positions 28-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P0A9H5. 14 interactions.
    STRINGi 511145.b1270.

    Proteomic databases

    PaxDbi P0A9H5.
    PRIDEi P0A9H5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC74352 ; AAC74352 ; b1270 .
    BAA14807 ; BAA14807 ; BAA14807 .
    GeneIDi 12930581.
    945839.
    KEGGi ecj:Y75_p1244.
    eco:b1270.
    PATRICi 32117798. VBIEscCol129921_1319.

    Organism-specific databases

    EchoBASEi EB0128.
    EcoGenei EG10130. btuR.

    Phylogenomic databases

    eggNOGi COG2109.
    HOGENOMi HOG000260311.
    KOi K00798.
    OMAi PVKHAFE.
    OrthoDBi EOG6GN76J.
    PhylomeDBi P0A9H5.

    Enzyme and pathway databases

    UniPathwayi UPA00148 ; UER00233 .
    BioCyci EcoCyc:COBALADENOSYLTRANS-MONOMER.
    ECOL316407:JW1262-MONOMER.

    Miscellaneous databases

    PROi P0A9H5.

    Gene expression databases

    Genevestigatori P0A9H5.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003724. AdoCbl_synth_CblAdoTrfase_CobA.
    IPR025826. Co_AT_N_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF12557. Co_AT_N. 1 hit.
    PF02572. CobA_CobO_BtuR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015617. Adensltrnsf_CobA. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00708. cobA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Altered cobalamin metabolism in Escherichia coli btuR mutants affects btuB gene regulation."
      Lundrigan M.D., Kadner R.J.
      J. Bacteriol. 171:154-161(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiBTUR_ECOLI
    AccessioniPrimary (citable) accession number: P0A9H5
    Secondary accession number(s): P13040
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3