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Protein

Lysine decarboxylase, inducible

Gene

cadA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in pH homeostasis by consuming protons and neutralizing the acidic by-products of carbohydrate fermentation.

Catalytic activityi

L-lysine = cadaverine + CO2.

Cofactori

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • lysine decarboxylase activity Source: EcoCyc

GO - Biological processi

  • lysine catabolic process Source: EcoliWiki
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciEcoCyc:LYSDECARBOX-MONOMER.
ECOL316407:JW4092-MONOMER.
MetaCyc:LYSDECARBOX-MONOMER.
BRENDAi4.1.1.18. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine decarboxylase, inducible (EC:4.1.1.18)
Short name:
LDC
Gene namesi
Name:cadA
Synonyms:ldcI
Ordered Locus Names:b4131, JW4092
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10131. cadA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 715715Lysine decarboxylase, induciblePRO_0000201138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei367 – 3671N6-(pyridoxal phosphate)lysine

Proteomic databases

PaxDbiP0A9H3.

Expressioni

Inductioni

At low pH in the presence of lysine, achieves maximal levels under anaerobic conditions. Expression controlled by CadC.1 Publication

Interactioni

Subunit structurei

Homodecamer at pH 7.0/low ionic strength and dimer at pH 8.0/high ionic strength. Interacts with RavA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself7EBI-545922,EBI-545922
ldcCP520953EBI-545922,EBI-545944
ravAP314737EBI-545922,EBI-561223

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4260777. 2 interactions.
DIPiDIP-35646N.
IntActiP0A9H3. 20 interactions.
MINTiMINT-1234345.
STRINGi511145.b4131.

Structurei

Secondary structure

1
715
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 75Combined sources
Helixi13 – 2816Combined sources
Beta strandi32 – 343Combined sources
Helixi39 – 4810Combined sources
Beta strandi52 – 587Combined sources
Helixi59 – 7315Combined sources
Beta strandi78 – 825Combined sources
Helixi91 – 933Combined sources
Beta strandi99 – 1035Combined sources
Helixi110 – 12819Combined sources
Helixi131 – 14212Combined sources
Turni151 – 1555Combined sources
Helixi156 – 1605Combined sources
Helixi162 – 17110Combined sources
Helixi173 – 1775Combined sources
Helixi185 – 1873Combined sources
Turni190 – 1934Combined sources
Helixi196 – 20813Combined sources
Beta strandi211 – 2188Combined sources
Helixi219 – 23113Combined sources
Beta strandi237 – 2437Combined sources
Helixi246 – 2549Combined sources
Beta strandi258 – 2625Combined sources
Helixi277 – 2804Combined sources
Helixi282 – 29110Combined sources
Beta strandi299 – 3068Combined sources
Beta strandi310 – 3134Combined sources
Helixi315 – 3217Combined sources
Beta strandi325 – 3306Combined sources
Helixi337 – 3393Combined sources
Helixi341 – 3433Combined sources
Beta strandi350 – 3523Combined sources
Beta strandi358 – 3636Combined sources
Helixi365 – 3684Combined sources
Beta strandi376 – 3827Combined sources
Helixi386 – 39510Combined sources
Helixi403 – 41614Combined sources
Helixi418 – 44528Combined sources
Beta strandi446 – 4483Combined sources
Beta strandi452 – 4554Combined sources
Beta strandi481 – 4866Combined sources
Beta strandi490 – 4945Combined sources
Helixi511 – 52010Combined sources
Beta strandi526 – 5294Combined sources
Beta strandi532 – 5365Combined sources
Helixi543 – 56119Combined sources
Helixi566 – 5694Combined sources
Helixi571 – 5766Combined sources
Helixi578 – 5814Combined sources
Helixi586 – 59914Combined sources
Helixi602 – 6098Combined sources
Beta strandi615 – 6184Combined sources
Helixi620 – 6289Combined sources
Beta strandi632 – 6365Combined sources
Helixi637 – 6393Combined sources
Beta strandi644 – 6474Combined sources
Beta strandi649 – 6524Combined sources
Helixi670 – 68213Combined sources
Beta strandi692 – 6943Combined sources
Beta strandi704 – 7096Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3N75X-ray2.00A/B/C/D/E1-715[»]
3Q16X-ray4.10A/B/C/D/E1-715[»]
4UPBelectron microscopy11.00A/B1-715[»]
4UPFelectron microscopy7.50A1-715[»]
ProteinModelPortaliP0A9H3.
SMRiP0A9H3. Positions 1-711.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9H3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN. Bacteria.
COG1982. LUCA.
HOGENOMiHOG000164394.
InParanoidiP0A9H3.
KOiK01582.
OMAiPSFYEGM.
PhylomeDBiP0A9H3.

Family and domain databases

CDDicd00615. Orn_deC_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009393. Orn_decarb. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVIAILNHM GVYFKEEPIR ELHRALERLN FQIVYPNDRD DLLKLIENNA
60 70 80 90 100
RLCGVIFDWD KYNLELCEEI SKMNENLPLY AFANTYSTLD VSLNDLRLQI
110 120 130 140 150
SFFEYALGAA EDIANKIKQT TDEYINTILP PLTKALFKYV REGKYTFCTP
160 170 180 190 200
GHMGGTAFQK SPVGSLFYDF FGPNTMKSDI SISVSELGSL LDHSGPHKEA
210 220 230 240 250
EQYIARVFNA DRSYMVTNGT STANKIVGMY SAPAGSTILI DRNCHKSLTH
260 270 280 290 300
LMMMSDVTPI YFRPTRNAYG ILGGIPQSEF QHATIAKRVK ETPNATWPVH
310 320 330 340 350
AVITNSTYDG LLYNTDFIKK TLDVKSIHFD SAWVPYTNFS PIYEGKCGMS
360 370 380 390 400
GGRVEGKVIY ETQSTHKLLA AFSQASMIHV KGDVNEETFN EAYMMHTTTS
410 420 430 440 450
PHYGIVASTE TAAAMMKGNA GKRLINGSIE RAIKFRKEIK RLRTESDGWF
460 470 480 490 500
FDVWQPDHID TTECWPLRSD STWHGFKNID NEHMYLDPIK VTLLTPGMEK
510 520 530 540 550
DGTMSDFGIP ASIVAKYLDE HGIVVEKTGP YNLLFLFSIG IDKTKALSLL
560 570 580 590 600
RALTDFKRAF DLNLRVKNML PSLYREDPEF YENMRIQELA QNIHKLIVHH
610 620 630 640 650
NLPDLMYRAF EVLPTMVMTP YAAFQKELHG MTEEVYLDEM VGRINANMIL
660 670 680 690 700
PYPPGVPLVM PGEMITEESR PVLEFLQMLC EIGAHYPGFE TDIHGAYRQA
710
DGRYTVKVLK EESKK
Length:715
Mass (Da):81,260
Last modified:July 19, 2005 - v1
Checksum:iB9776622A0AE0190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76411 Genomic DNA. Translation: AAA23536.1.
U14003 Genomic DNA. Translation: AAA97031.1.
U00096 Genomic DNA. Translation: AAC77092.1.
AP009048 Genomic DNA. Translation: BAE78134.1.
M67452 Genomic DNA. Translation: AAA23533.1.
PIRiB41842.
RefSeqiNP_418555.1. NC_000913.3.
WP_001295383.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77092; AAC77092; b4131.
BAE78134; BAE78134; BAE78134.
GeneIDi948643.
KEGGiecj:JW4092.
eco:b4131.
PATRICi32123829. VBIEscCol129921_4263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76411 Genomic DNA. Translation: AAA23536.1.
U14003 Genomic DNA. Translation: AAA97031.1.
U00096 Genomic DNA. Translation: AAC77092.1.
AP009048 Genomic DNA. Translation: BAE78134.1.
M67452 Genomic DNA. Translation: AAA23533.1.
PIRiB41842.
RefSeqiNP_418555.1. NC_000913.3.
WP_001295383.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3N75X-ray2.00A/B/C/D/E1-715[»]
3Q16X-ray4.10A/B/C/D/E1-715[»]
4UPBelectron microscopy11.00A/B1-715[»]
4UPFelectron microscopy7.50A1-715[»]
ProteinModelPortaliP0A9H3.
SMRiP0A9H3. Positions 1-711.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260777. 2 interactions.
DIPiDIP-35646N.
IntActiP0A9H3. 20 interactions.
MINTiMINT-1234345.
STRINGi511145.b4131.

Proteomic databases

PaxDbiP0A9H3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77092; AAC77092; b4131.
BAE78134; BAE78134; BAE78134.
GeneIDi948643.
KEGGiecj:JW4092.
eco:b4131.
PATRICi32123829. VBIEscCol129921_4263.

Organism-specific databases

EchoBASEiEB0129.
EcoGeneiEG10131. cadA.

Phylogenomic databases

eggNOGiENOG4105CXN. Bacteria.
COG1982. LUCA.
HOGENOMiHOG000164394.
InParanoidiP0A9H3.
KOiK01582.
OMAiPSFYEGM.
PhylomeDBiP0A9H3.

Enzyme and pathway databases

BioCyciEcoCyc:LYSDECARBOX-MONOMER.
ECOL316407:JW4092-MONOMER.
MetaCyc:LYSDECARBOX-MONOMER.
BRENDAi4.1.1.18. 2026.

Miscellaneous databases

EvolutionaryTraceiP0A9H3.
PROiP0A9H3.

Family and domain databases

CDDicd00615. Orn_deC_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009393. Orn_decarb. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLDCI_ECOLI
AccessioniPrimary (citable) accession number: P0A9H3
Secondary accession number(s): P23892, Q2M6H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.