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Protein

Lysine decarboxylase, inducible

Gene

cadA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in pH homeostasis by consuming protons and neutralizing the acidic by-products of carbohydrate fermentation.

Catalytic activityi

L-lysine = cadaverine + CO2.

Cofactori

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • lysine decarboxylase activity Source: EcoCyc

GO - Biological processi

  • lysine catabolic process Source: EcoliWiki
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciEcoCyc:LYSDECARBOX-MONOMER.
ECOL316407:JW4092-MONOMER.
MetaCyc:LYSDECARBOX-MONOMER.
BRENDAi4.1.1.18. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine decarboxylase, inducible (EC:4.1.1.18)
Short name:
LDC
Gene namesi
Name:cadA
Synonyms:ldcI
Ordered Locus Names:b4131, JW4092
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10131. cadA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011381 – 715Lysine decarboxylase, inducibleAdd BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei367N6-(pyridoxal phosphate)lysine1

Proteomic databases

PaxDbiP0A9H3.
PRIDEiP0A9H3.

Expressioni

Inductioni

At low pH in the presence of lysine, achieves maximal levels under anaerobic conditions. Expression controlled by CadC.1 Publication

Interactioni

Subunit structurei

Homodecamer at pH 7.0/low ionic strength and dimer at pH 8.0/high ionic strength. Interacts with RavA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself7EBI-545922,EBI-545922
ldcCP520953EBI-545922,EBI-545944
ravAP314737EBI-545922,EBI-561223

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4260777. 2 interactors.
DIPiDIP-35646N.
IntActiP0A9H3. 20 interactors.
MINTiMINT-1234345.
STRINGi511145.b4131.

Structurei

Secondary structure

1715
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi13 – 28Combined sources16
Beta strandi32 – 34Combined sources3
Helixi39 – 48Combined sources10
Beta strandi52 – 58Combined sources7
Helixi59 – 73Combined sources15
Beta strandi78 – 82Combined sources5
Helixi91 – 93Combined sources3
Beta strandi99 – 103Combined sources5
Helixi110 – 128Combined sources19
Helixi131 – 142Combined sources12
Turni151 – 155Combined sources5
Helixi156 – 160Combined sources5
Helixi162 – 171Combined sources10
Helixi173 – 177Combined sources5
Helixi185 – 187Combined sources3
Turni190 – 193Combined sources4
Helixi196 – 208Combined sources13
Beta strandi211 – 218Combined sources8
Helixi219 – 231Combined sources13
Beta strandi237 – 243Combined sources7
Helixi246 – 254Combined sources9
Beta strandi258 – 262Combined sources5
Helixi277 – 280Combined sources4
Helixi282 – 291Combined sources10
Beta strandi299 – 306Combined sources8
Beta strandi310 – 313Combined sources4
Helixi315 – 321Combined sources7
Beta strandi325 – 330Combined sources6
Helixi337 – 339Combined sources3
Helixi341 – 343Combined sources3
Beta strandi350 – 352Combined sources3
Beta strandi358 – 363Combined sources6
Helixi365 – 368Combined sources4
Beta strandi376 – 382Combined sources7
Helixi386 – 395Combined sources10
Helixi403 – 416Combined sources14
Helixi418 – 445Combined sources28
Beta strandi446 – 448Combined sources3
Beta strandi452 – 455Combined sources4
Beta strandi481 – 486Combined sources6
Beta strandi490 – 494Combined sources5
Helixi511 – 520Combined sources10
Beta strandi526 – 529Combined sources4
Beta strandi532 – 536Combined sources5
Helixi543 – 561Combined sources19
Helixi566 – 569Combined sources4
Helixi571 – 576Combined sources6
Helixi578 – 581Combined sources4
Helixi586 – 599Combined sources14
Helixi602 – 609Combined sources8
Beta strandi615 – 618Combined sources4
Helixi620 – 628Combined sources9
Beta strandi632 – 636Combined sources5
Helixi637 – 639Combined sources3
Beta strandi644 – 647Combined sources4
Beta strandi649 – 652Combined sources4
Helixi670 – 682Combined sources13
Beta strandi692 – 694Combined sources3
Beta strandi704 – 709Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N75X-ray2.00A/B/C/D/E1-715[»]
3Q16X-ray4.10A/B/C/D/E1-715[»]
4UPBelectron microscopy11.00A/B1-715[»]
4UPFelectron microscopy7.50A1-715[»]
5FKXelectron microscopy6.10A1-711[»]
5FL2electron microscopy6.20A1-711[»]
ProteinModelPortaliP0A9H3.
SMRiP0A9H3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9H3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN. Bacteria.
COG1982. LUCA.
HOGENOMiHOG000164394.
InParanoidiP0A9H3.
KOiK01582.
OMAiPSFYEGM.
PhylomeDBiP0A9H3.

Family and domain databases

CDDicd00615. Orn_deC_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009393. Orn_decarb. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVIAILNHM GVYFKEEPIR ELHRALERLN FQIVYPNDRD DLLKLIENNA
60 70 80 90 100
RLCGVIFDWD KYNLELCEEI SKMNENLPLY AFANTYSTLD VSLNDLRLQI
110 120 130 140 150
SFFEYALGAA EDIANKIKQT TDEYINTILP PLTKALFKYV REGKYTFCTP
160 170 180 190 200
GHMGGTAFQK SPVGSLFYDF FGPNTMKSDI SISVSELGSL LDHSGPHKEA
210 220 230 240 250
EQYIARVFNA DRSYMVTNGT STANKIVGMY SAPAGSTILI DRNCHKSLTH
260 270 280 290 300
LMMMSDVTPI YFRPTRNAYG ILGGIPQSEF QHATIAKRVK ETPNATWPVH
310 320 330 340 350
AVITNSTYDG LLYNTDFIKK TLDVKSIHFD SAWVPYTNFS PIYEGKCGMS
360 370 380 390 400
GGRVEGKVIY ETQSTHKLLA AFSQASMIHV KGDVNEETFN EAYMMHTTTS
410 420 430 440 450
PHYGIVASTE TAAAMMKGNA GKRLINGSIE RAIKFRKEIK RLRTESDGWF
460 470 480 490 500
FDVWQPDHID TTECWPLRSD STWHGFKNID NEHMYLDPIK VTLLTPGMEK
510 520 530 540 550
DGTMSDFGIP ASIVAKYLDE HGIVVEKTGP YNLLFLFSIG IDKTKALSLL
560 570 580 590 600
RALTDFKRAF DLNLRVKNML PSLYREDPEF YENMRIQELA QNIHKLIVHH
610 620 630 640 650
NLPDLMYRAF EVLPTMVMTP YAAFQKELHG MTEEVYLDEM VGRINANMIL
660 670 680 690 700
PYPPGVPLVM PGEMITEESR PVLEFLQMLC EIGAHYPGFE TDIHGAYRQA
710
DGRYTVKVLK EESKK
Length:715
Mass (Da):81,260
Last modified:July 19, 2005 - v1
Checksum:iB9776622A0AE0190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76411 Genomic DNA. Translation: AAA23536.1.
U14003 Genomic DNA. Translation: AAA97031.1.
U00096 Genomic DNA. Translation: AAC77092.1.
AP009048 Genomic DNA. Translation: BAE78134.1.
M67452 Genomic DNA. Translation: AAA23533.1.
PIRiB41842.
RefSeqiNP_418555.1. NC_000913.3.
WP_001295383.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77092; AAC77092; b4131.
BAE78134; BAE78134; BAE78134.
GeneIDi948643.
KEGGiecj:JW4092.
eco:b4131.
PATRICi32123829. VBIEscCol129921_4263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76411 Genomic DNA. Translation: AAA23536.1.
U14003 Genomic DNA. Translation: AAA97031.1.
U00096 Genomic DNA. Translation: AAC77092.1.
AP009048 Genomic DNA. Translation: BAE78134.1.
M67452 Genomic DNA. Translation: AAA23533.1.
PIRiB41842.
RefSeqiNP_418555.1. NC_000913.3.
WP_001295383.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N75X-ray2.00A/B/C/D/E1-715[»]
3Q16X-ray4.10A/B/C/D/E1-715[»]
4UPBelectron microscopy11.00A/B1-715[»]
4UPFelectron microscopy7.50A1-715[»]
5FKXelectron microscopy6.10A1-711[»]
5FL2electron microscopy6.20A1-711[»]
ProteinModelPortaliP0A9H3.
SMRiP0A9H3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260777. 2 interactors.
DIPiDIP-35646N.
IntActiP0A9H3. 20 interactors.
MINTiMINT-1234345.
STRINGi511145.b4131.

Proteomic databases

PaxDbiP0A9H3.
PRIDEiP0A9H3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77092; AAC77092; b4131.
BAE78134; BAE78134; BAE78134.
GeneIDi948643.
KEGGiecj:JW4092.
eco:b4131.
PATRICi32123829. VBIEscCol129921_4263.

Organism-specific databases

EchoBASEiEB0129.
EcoGeneiEG10131. cadA.

Phylogenomic databases

eggNOGiENOG4105CXN. Bacteria.
COG1982. LUCA.
HOGENOMiHOG000164394.
InParanoidiP0A9H3.
KOiK01582.
OMAiPSFYEGM.
PhylomeDBiP0A9H3.

Enzyme and pathway databases

BioCyciEcoCyc:LYSDECARBOX-MONOMER.
ECOL316407:JW4092-MONOMER.
MetaCyc:LYSDECARBOX-MONOMER.
BRENDAi4.1.1.18. 2026.

Miscellaneous databases

EvolutionaryTraceiP0A9H3.
PROiP0A9H3.

Family and domain databases

CDDicd00615. Orn_deC_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009393. Orn_decarb. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLDCI_ECOLI
AccessioniPrimary (citable) accession number: P0A9H3
Secondary accession number(s): P23892, Q2M6H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.