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Protein

Glycine cleavage system transcriptional activator

Gene

gcvA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi23 – 42H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: EcoliWiki
  • response to UV Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00339

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system transcriptional activator
Alternative name(s):
Gcv operon activator
Gene namesi
Name:gcvA
Ordered Locus Names:b2808, JW2779
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11795 gcvA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056251 – 305Glycine cleavage system transcriptional activatorAdd BLAST305

Proteomic databases

PaxDbiP0A9F6
PRIDEiP0A9F6

Interactioni

Protein-protein interaction databases

BioGridi4261124, 25 interactors
DIPiDIP-9751N
IntActiP0A9F6, 2 interactors
STRINGi316385.ECDH10B_2977

Structurei

3D structure databases

ProteinModelPortaliP0A9F6
SMRiP0A9F6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 63HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4105ETT Bacteria
ENOG410XS6G LUCA
HOGENOMiHOG000233528
InParanoidiP0A9F6
KOiK03566
OMAiFNLAYPG
PhylomeDBiP0A9F6

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRLPPLNA LRVFDAAARH LSFTRAAEEL FVTQAAVSHQ IKSLEDFLGL
60 70 80 90 100
KLFRRRNRSL LLTEEGQSYF LDIKEIFSQL TEATRKLQAR SAKGALTVSL
110 120 130 140 150
LPSFAIHWLV PRLSSFNSAY PGIDVRIQAV DRQEDKLADD VDVAIFYGRG
160 170 180 190 200
NWPGLRVEKL YAEYLLPVCS PLLLTGEKPL KTPEDLAKHT LLHDASRRDW
210 220 230 240 250
QTYTRQLGLN HINVQQGPIF SHSAMVLQAA IHGQGVALAN NVMAQSEIEA
260 270 280 290 300
GRLVCPFNDV LVSKNAFYLV CHDSQAELGK IAAFRQWILA KAAAEQEKFR

FRYEQ
Length:305
Mass (Da):34,402
Last modified:July 19, 2005 - v1
Checksum:i42AE40C64DAB5F72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01030 Genomic DNA Translation: AAC13742.1
X73413 Genomic DNA Translation: CAA51813.1
U29581 Genomic DNA Translation: AAB40458.1
U00096 Genomic DNA Translation: AAC75850.1
AP009048 Genomic DNA Translation: BAE76880.1
PIRiI41065
RefSeqiNP_417288.1, NC_000913.3
WP_000044401.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75850; AAC75850; b2808
BAE76880; BAE76880; BAE76880
GeneIDi947278
KEGGiecj:JW2779
eco:b2808
PATRICifig|1411691.4.peg.3925

Similar proteinsi

Entry informationi

Entry nameiGCVA_ECOLI
AccessioniPrimary (citable) accession number: P0A9F6
Secondary accession number(s): P32064, Q2MA26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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