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Protein

Transcriptional regulator MntR

Gene

mntR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP.2 Publications

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of DNA-templated transcription, initiation Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Manganese

Enzyme and pathway databases

BioCyciEcoCyc:G6420-MONOMER.
ECOL316407:JW0801-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator MntR
Alternative name(s):
Manganese transport regulator
Gene namesi
Name:mntR
Synonyms:ybiQ
Ordered Locus Names:b0817, JW0801
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13322. mntR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011101 – 155Transcriptional regulator MntRAdd BLAST155

Proteomic databases

PaxDbiP0A9F1.
PRIDEiP0A9F1.

Expressioni

Gene expression databases

CollecTFiEXPREG_000007f0.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
hycGP164334EBI-541895,EBI-541977
metNP307503EBI-541895,EBI-541886

Protein-protein interaction databases

BioGridi4261205. 10 interactors.
DIPiDIP-28083N.
IntActiP0A9F1. 10 interactors.
STRINGi511145.b0817.

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi27 – 52Combined sources26
Helixi57 – 64Combined sources8
Helixi68 – 80Combined sources13
Beta strandi84 – 87Combined sources4
Turni88 – 90Combined sources3
Beta strandi91 – 94Combined sources4
Helixi96 – 119Combined sources24
Helixi123 – 133Combined sources11
Helixi134 – 136Combined sources3
Helixi139 – 147Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H09X-ray2.10A1-155[»]
ProteinModelPortaliP0A9F1.
SMRiP0A9F1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9F1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 95HTH dtxR-typePROSITE-ProRule annotationAdd BLAST62

Domaini

It contains an N-terminal DNA-binding domain and a metal-binding domain.1 Publication

Sequence similaritiesi

Contains 1 HTH dtxR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105KST. Bacteria.
COG1321. LUCA.
HOGENOMiHOG000040349.
InParanoidiP0A9F1.
KOiK11924.
OMAiCPYVLKQ.
PhylomeDBiP0A9F1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.60.10. 1 hit.
InterProiIPR001367. Fe_dep_repressor.
IPR022687. HTH_DTXR.
IPR022689. Iron_dep_repressor.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02742. Fe_dep_repr_C. 1 hit.
PF01325. Fe_dep_repress. 1 hit.
[Graphical view]
SMARTiSM00529. HTH_DTXR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47979. SSF47979. 1 hit.
PROSITEiPS50944. HTH_DTXR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRAGTPTA KKVTQLVNVE EHVEGFRQVR EAHRRELIDD YVELISDLIR
60 70 80 90 100
EVGEARQVDM AARLGVSQPT VAKMLKRLAT MGLIEMIPWR GVFLTAEGEK
110 120 130 140 150
LAQESRERHQ IVENFLLVLG VSPEIARRDA EGMEHHVSEE TLDAFRLFTQ

KHGAK
Length:155
Mass (Da):17,640
Last modified:July 19, 2005 - v1
Checksum:iCB316AC7F1BDD106
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73904.1.
AP009048 Genomic DNA. Translation: BAA35488.1.
PIRiA64819.
RefSeqiNP_415338.1. NC_000913.3.
WP_000091016.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73904; AAC73904; b0817.
BAA35488; BAA35488; BAA35488.
GeneIDi945437.
KEGGiecj:JW0801.
eco:b0817.
PATRICi32116837. VBIEscCol129921_0844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73904.1.
AP009048 Genomic DNA. Translation: BAA35488.1.
PIRiA64819.
RefSeqiNP_415338.1. NC_000913.3.
WP_000091016.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H09X-ray2.10A1-155[»]
ProteinModelPortaliP0A9F1.
SMRiP0A9F1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261205. 10 interactors.
DIPiDIP-28083N.
IntActiP0A9F1. 10 interactors.
STRINGi511145.b0817.

Proteomic databases

PaxDbiP0A9F1.
PRIDEiP0A9F1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73904; AAC73904; b0817.
BAA35488; BAA35488; BAA35488.
GeneIDi945437.
KEGGiecj:JW0801.
eco:b0817.
PATRICi32116837. VBIEscCol129921_0844.

Organism-specific databases

EchoBASEiEB3106.
EcoGeneiEG13322. mntR.

Phylogenomic databases

eggNOGiENOG4105KST. Bacteria.
COG1321. LUCA.
HOGENOMiHOG000040349.
InParanoidiP0A9F1.
KOiK11924.
OMAiCPYVLKQ.
PhylomeDBiP0A9F1.

Enzyme and pathway databases

BioCyciEcoCyc:G6420-MONOMER.
ECOL316407:JW0801-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A9F1.
PROiP0A9F1.

Gene expression databases

CollecTFiEXPREG_000007f0.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.60.10. 1 hit.
InterProiIPR001367. Fe_dep_repressor.
IPR022687. HTH_DTXR.
IPR022689. Iron_dep_repressor.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02742. Fe_dep_repr_C. 1 hit.
PF01325. Fe_dep_repress. 1 hit.
[Graphical view]
SMARTiSM00529. HTH_DTXR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47979. SSF47979. 1 hit.
PROSITEiPS50944. HTH_DTXR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMNTR_ECOLI
AccessioniPrimary (citable) accession number: P0A9F1
Secondary accession number(s): P75787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.