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Protein

Transcriptional regulator MntR

Gene

mntR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP.2 Publications

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of DNA-templated transcription, initiation Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandManganese

Enzyme and pathway databases

BioCyciEcoCyc:G6420-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator MntR
Alternative name(s):
Manganese transport regulator
Gene namesi
Name:mntR
Synonyms:ybiQ
Ordered Locus Names:b0817, JW0801
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13322 mntR

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • protein-DNA complex Source: CollecTF

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011101 – 155Transcriptional regulator MntRAdd BLAST155

Proteomic databases

PaxDbiP0A9F1
PRIDEiP0A9F1

Expressioni

Gene expression databases

CollecTFiEXPREG_000007f0

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4261205, 12 interactors
DIPiDIP-28083N
IntActiP0A9F1, 10 interactors
STRINGi316385.ECDH10B_0886

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi27 – 52Combined sources26
Helixi57 – 64Combined sources8
Helixi68 – 80Combined sources13
Beta strandi84 – 87Combined sources4
Turni88 – 90Combined sources3
Beta strandi91 – 94Combined sources4
Helixi96 – 119Combined sources24
Helixi123 – 133Combined sources11
Helixi134 – 136Combined sources3
Helixi139 – 147Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H09X-ray2.10A1-155[»]
ProteinModelPortaliP0A9F1
SMRiP0A9F1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9F1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 95HTH dtxR-typePROSITE-ProRule annotationAdd BLAST62

Domaini

It contains an N-terminal DNA-binding domain and a metal-binding domain.1 Publication

Phylogenomic databases

eggNOGiENOG4105KST Bacteria
COG1321 LUCA
HOGENOMiHOG000040349
InParanoidiP0A9F1
KOiK11924
OMAiCIIERFL
PhylomeDBiP0A9F1

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.60.10, 1 hit
InterProiView protein in InterPro
IPR001367 Fe_dep_repressor
IPR036421 Fe_dep_repressor_sf
IPR022687 HTH_DTXR
IPR022689 Iron_dep_repressor
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF02742 Fe_dep_repr_C, 1 hit
PF01325 Fe_dep_repress, 1 hit
SMARTiView protein in SMART
SM00529 HTH_DTXR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47979 SSF47979, 1 hit
PROSITEiView protein in PROSITE
PS50944 HTH_DTXR, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRAGTPTA KKVTQLVNVE EHVEGFRQVR EAHRRELIDD YVELISDLIR
60 70 80 90 100
EVGEARQVDM AARLGVSQPT VAKMLKRLAT MGLIEMIPWR GVFLTAEGEK
110 120 130 140 150
LAQESRERHQ IVENFLLVLG VSPEIARRDA EGMEHHVSEE TLDAFRLFTQ

KHGAK
Length:155
Mass (Da):17,640
Last modified:July 19, 2005 - v1
Checksum:iCB316AC7F1BDD106
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73904.1
AP009048 Genomic DNA Translation: BAA35488.1
PIRiA64819
RefSeqiNP_415338.1, NC_000913.3
WP_000091016.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73904; AAC73904; b0817
BAA35488; BAA35488; BAA35488
GeneIDi945437
KEGGiecj:JW0801
eco:b0817
PATRICifig|1411691.4.peg.1461

Similar proteinsi

Entry informationi

Entry nameiMNTR_ECOLI
AccessioniPrimary (citable) accession number: P0A9F1
Secondary accession number(s): P75787
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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