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Protein

Regulatory protein YeiL

Gene

yeiL

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcription regulator involved in mid-term, stationary-phase viability under nitrogen starvation. Might control expression of the salvage pathways or in some other way repress the recycling of nucleobases to nucleic acids and enhance their use as general nitrogen sources during nitrogen-limited growth (By similarity).By similarity

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi91Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi93Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi116Iron-sulfur (4Fe-4S)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi158 – 181H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein YeiL
Gene namesi
Name:yeiL
Ordered Locus Names:Z3420, ECs3055
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001831 – 219Regulatory protein YeiLAdd BLAST219

Proteomic databases

PRIDEiP0A9F0

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi155864.Z3420

Structurei

3D structure databases

ProteinModelPortaliP0A9F0
SMRiP0A9F0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 199HTH crp-typePROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 97Sensory domainSequence analysisAdd BLAST79
Regioni111 – 131Dimer interfaceSequence analysisAdd BLAST21

Phylogenomic databases

eggNOGiENOG4108Y4K Bacteria
COG0664 LUCA
HOGENOMiHOG000094699
KOiK16326
OMAiTSNVQVM

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR012318 HTH_CRP
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS51063 HTH_CRP_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESAFKDCF LTDVSADTRL FHFLARDYIV QEGQQPSWLF YLTRGRARLY
60 70 80 90 100
ATLANGRVSL IDFFAAPCFI GEIELIDKDH EPRAVQAIEE CWCLALPMKH
110 120 130 140 150
YRPLLLNDTL FLRKLCVTLS HKNYRNIVSL TQNQSFPLVN RLAAFILLSQ
160 170 180 190 200
EGDLYHEKHT QAAEYLGVSY RHLLYVLAQF IHDGLLIKSK KGYLIKNRKQ
210
LSGLALEMDP ENKFSGMMQ
Length:219
Mass (Da):25,294
Last modified:July 19, 2005 - v1
Checksum:i47720B07A9FD412D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG57301.1
BA000007 Genomic DNA Translation: BAB36478.1
PIRiA85855
G91010
RefSeqiNP_311082.3, NC_002695.1

Genome annotation databases

EnsemblBacteriaiAAG57301; AAG57301; Z3420
BAB36478; BAB36478; BAB36478
GeneIDi916759
KEGGiece:Z3420
ecs:ECs3055
PATRICifig|386585.9.peg.3184

Similar proteinsi

Entry informationi

Entry nameiYEIL_ECO57
AccessioniPrimary (citable) accession number: P0A9F0
Secondary accession number(s): P33023
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health