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P0A9F0

- YEIL_ECO57

UniProt

P0A9F0 - YEIL_ECO57

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Protein

Regulatory protein YeiL

Gene

yeiL

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Transcription regulator involved in mid-term, stationary-phase viability under nitrogen starvation. Might control expression of the salvage pathways or in some other way repress the recycling of nucleobases to nucleic acids and enhance their use as general nitrogen sources during nitrogen-limited growth By similarity.By similarity

Cofactori

Binds 1 4Fe-4S cluster per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi91 – 911Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi93 – 931Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi116 – 1161Iron-sulfur (4Fe-4S)Sequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi158 – 18124H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

4Fe-4S, DNA-binding, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3004-MONOMER.
ECOO157:YEIL-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein YeiL
Gene namesi
Name:yeiL
Ordered Locus Names:Z3420, ECs3055
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Regulatory protein YeiLPRO_0000100183Add
BLAST

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi155864.Z3420.

Structurei

3D structure databases

ProteinModelPortaliP0A9F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 19964HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 9779Sensory domainSequence AnalysisAdd
BLAST
Regioni111 – 13121Dimer interfaceSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000094699.
KOiK16326.
OMAiCFIGEME.
OrthoDBiEOG686NMR.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9F0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSESAFKDCF LTDVSADTRL FHFLARDYIV QEGQQPSWLF YLTRGRARLY
60 70 80 90 100
ATLANGRVSL IDFFAAPCFI GEIELIDKDH EPRAVQAIEE CWCLALPMKH
110 120 130 140 150
YRPLLLNDTL FLRKLCVTLS HKNYRNIVSL TQNQSFPLVN RLAAFILLSQ
160 170 180 190 200
EGDLYHEKHT QAAEYLGVSY RHLLYVLAQF IHDGLLIKSK KGYLIKNRKQ
210
LSGLALEMDP ENKFSGMMQ
Length:219
Mass (Da):25,294
Last modified:July 19, 2005 - v1
Checksum:i47720B07A9FD412D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG57301.1.
BA000007 Genomic DNA. Translation: BAB36478.1.
PIRiA85855.
G91010.
RefSeqiNP_288746.1. NC_002655.2.
NP_311082.2. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG57301; AAG57301; Z3420.
BAB36478; BAB36478; BAB36478.
GeneIDi916759.
957264.
KEGGiece:Z3420.
ecs:ECs3055.
PATRICi18355482. VBIEscCol44059_2943.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG57301.1 .
BA000007 Genomic DNA. Translation: BAB36478.1 .
PIRi A85855.
G91010.
RefSeqi NP_288746.1. NC_002655.2.
NP_311082.2. NC_002695.1.

3D structure databases

ProteinModelPortali P0A9F0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z3420.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG57301 ; AAG57301 ; Z3420 .
BAB36478 ; BAB36478 ; BAB36478 .
GeneIDi 916759.
957264.
KEGGi ece:Z3420.
ecs:ECs3055.
PATRICi 18355482. VBIEscCol44059_2943.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000094699.
KOi K16326.
OMAi CFIGEME.
OrthoDBi EOG686NMR.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-3004-MONOMER.
ECOO157:YEIL-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiYEIL_ECO57
AccessioniPrimary (citable) accession number: P0A9F0
Secondary accession number(s): P33023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3