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Protein

Regulatory protein YeiL

Gene

yeiL

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcription regulator involved in mid-term, stationary-phase viability under nitrogen starvation. Might control expression of the salvage pathways or in some other way repress the recycling of nucleobases to nucleic acids and enhance their use as general nitrogen sources during nitrogen-limited growth (By similarity).By similarity

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi91Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi93Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi116Iron-sulfur (4Fe-4S)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi158 – 181H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

4Fe-4S, DNA-binding, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciECOO157:YEIL-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein YeiL
Gene namesi
Name:yeiL
Ordered Locus Names:Z3420, ECs3055
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001831 – 219Regulatory protein YeiLAdd BLAST219

Proteomic databases

PRIDEiP0A9F0.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi155864.Z3420.

Structurei

3D structure databases

ProteinModelPortaliP0A9F0.
SMRiP0A9F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 199HTH crp-typePROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 97Sensory domainSequence analysisAdd BLAST79
Regioni111 – 131Dimer interfaceSequence analysisAdd BLAST21

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108Y4K. Bacteria.
COG0664. LUCA.
HOGENOMiHOG000094699.
KOiK16326.
OMAiQDATFLQ.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESAFKDCF LTDVSADTRL FHFLARDYIV QEGQQPSWLF YLTRGRARLY
60 70 80 90 100
ATLANGRVSL IDFFAAPCFI GEIELIDKDH EPRAVQAIEE CWCLALPMKH
110 120 130 140 150
YRPLLLNDTL FLRKLCVTLS HKNYRNIVSL TQNQSFPLVN RLAAFILLSQ
160 170 180 190 200
EGDLYHEKHT QAAEYLGVSY RHLLYVLAQF IHDGLLIKSK KGYLIKNRKQ
210
LSGLALEMDP ENKFSGMMQ
Length:219
Mass (Da):25,294
Last modified:July 19, 2005 - v1
Checksum:i47720B07A9FD412D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57301.1.
BA000007 Genomic DNA. Translation: BAB36478.1.
PIRiA85855.
G91010.
RefSeqiNP_311082.2. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG57301; AAG57301; Z3420.
BAB36478; BAB36478; BAB36478.
GeneIDi916759.
KEGGiece:Z3420.
ecs:ECs3055.
PATRICi18355482. VBIEscCol44059_2943.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57301.1.
BA000007 Genomic DNA. Translation: BAB36478.1.
PIRiA85855.
G91010.
RefSeqiNP_311082.2. NC_002695.1.

3D structure databases

ProteinModelPortaliP0A9F0.
SMRiP0A9F0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z3420.

Proteomic databases

PRIDEiP0A9F0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG57301; AAG57301; Z3420.
BAB36478; BAB36478; BAB36478.
GeneIDi916759.
KEGGiece:Z3420.
ecs:ECs3055.
PATRICi18355482. VBIEscCol44059_2943.

Phylogenomic databases

eggNOGiENOG4108Y4K. Bacteria.
COG0664. LUCA.
HOGENOMiHOG000094699.
KOiK16326.
OMAiQDATFLQ.

Enzyme and pathway databases

BioCyciECOO157:YEIL-MONOMER.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYEIL_ECO57
AccessioniPrimary (citable) accession number: P0A9F0
Secondary accession number(s): P33023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.