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P0A9E9

- YEIL_ECOLI

UniProt

P0A9E9 - YEIL_ECOLI

Protein

Regulatory protein YeiL

Gene

yeiL

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Transcription regulator involved in mid-term, stationary-phase viability under nitrogen starvation. Might control expression of the salvage pathways or in some other way repress the recycling of nucleobases to nucleic acids and enhance their use as general nitrogen sources during nitrogen-limited growth.1 Publication

    Cofactori

    Binds 1 4Fe-4S cluster per subunit.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi68 – 681Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi91 – 911Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi93 – 931Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi116 – 1161Iron-sulfur (4Fe-4S)Sequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi158 – 18124H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: EcoCyc

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    4Fe-4S, DNA-binding, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:EG12031-MONOMER.
    ECOL316407:JW2150-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulatory protein YeiL
    Gene namesi
    Name:yeiL
    Synonyms:nsr
    Ordered Locus Names:b2163, JW2150
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG12031. yeiL.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219Regulatory protein YeiLPRO_0000100182Add
    BLAST

    Proteomic databases

    PRIDEiP0A9E9.

    Expressioni

    Inductioni

    In the stationary phase, aerobic expression is positively autoregulated and significantly dependent on RpoS and Lrp. Its transcription is directly or indirectly repressed by FNR.1 Publication

    Gene expression databases

    GenevestigatoriP0A9E9.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    STRINGi511145.b2163.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A9E9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini136 – 19964HTH crp-typePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 9779Sensory domainSequence AnalysisAdd
    BLAST
    Regioni111 – 13121Dimer interfaceSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000094699.
    KOiK16326.
    OMAiCFIGEME.
    OrthoDBiEOG686NMR.
    PhylomeDBiP0A9E9.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A9E9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSESAFKDCF LTDVSADTRL FHFLARDYIV QEGQQPSWLF YLTRGRARLY    50
    ATLANGRVSL IDFFAAPCFI GEIELIDKDH EPRAVQAIEE CWCLALPMKH 100
    YRPLLLNDTL FLRKLCVTLS HKNYRNIVSL TQNQSFPLVN RLAAFILLSQ 150
    EGDLYHEKHT QAAEYLGVSY RHLLYVLAQF IHDGLLIKSK KGYLIKNRKQ 200
    LSGLALEMDP ENKFSGMMQ 219
    Length:219
    Mass (Da):25,294
    Last modified:July 19, 2005 - v1
    Checksum:i47720B07A9FD412D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00007 Genomic DNA. Translation: AAA60515.1.
    U00096 Genomic DNA. Translation: AAC75224.1.
    AP009048 Genomic DNA. Translation: BAE76640.1.
    PIRiB64985.
    RefSeqiNP_416668.3. NC_000913.3.
    YP_490402.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75224; AAC75224; b2163.
    BAE76640; BAE76640; BAE76640.
    GeneIDi12931468.
    946670.
    KEGGiecj:Y75_p2125.
    eco:b2163.
    PATRICi32119675. VBIEscCol129921_2248.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00007 Genomic DNA. Translation: AAA60515.1 .
    U00096 Genomic DNA. Translation: AAC75224.1 .
    AP009048 Genomic DNA. Translation: BAE76640.1 .
    PIRi B64985.
    RefSeqi NP_416668.3. NC_000913.3.
    YP_490402.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P0A9E9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 511145.b2163.

    Proteomic databases

    PRIDEi P0A9E9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75224 ; AAC75224 ; b2163 .
    BAE76640 ; BAE76640 ; BAE76640 .
    GeneIDi 12931468.
    946670.
    KEGGi ecj:Y75_p2125.
    eco:b2163.
    PATRICi 32119675. VBIEscCol129921_2248.

    Organism-specific databases

    EchoBASEi EB1966.
    EcoGenei EG12031. yeiL.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000094699.
    KOi K16326.
    OMAi CFIGEME.
    OrthoDBi EOG686NMR.
    PhylomeDBi P0A9E9.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG12031-MONOMER.
    ECOL316407:JW2150-MONOMER.

    Miscellaneous databases

    PROi P0A9E9.

    Gene expression databases

    Genevestigatori P0A9E9.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Automated multiplex sequencing of the E.coli genome."
      Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K., Church G.M.
      Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / BHB2600.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "YeiL, the third member of the CRP-FNR family in Escherichia coli."
      Anjum M.F., Green J., Guest J.R.
      Microbiology 146:3157-3170(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, COFACTOR, SUBUNIT, SUBCELLULAR LOCATION, INDUCTION.
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiYEIL_ECOLI
    AccessioniPrimary (citable) accession number: P0A9E9
    Secondary accession number(s): P33023, Q2MAR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Its activity might be modulated by a sensory iron-sulfur cluster, by reversible dithiol-disulfide formation, or by both mechanisms. It is not an oxygen-responsive regulator.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3