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Protein

Regulatory protein SoxS

Gene

soxS

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN7CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi24 – 4320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-5048-MONOMER.
ECOO157:SOXS-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein SoxS
Gene namesi
Name:soxS
Ordered Locus Names:Z5661, ECs5044
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 107106Regulatory protein SoxSPRO_0000194584Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5661.

Structurei

3D structure databases

ProteinModelPortaliP0A9E4.
SMRiP0A9E4. Positions 6-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108W3Q. Bacteria.
ENOG4111IXA. LUCA.
HOGENOMiHOG000120762.
KOiK13631.
OMAiLTHWIDQ.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A9E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHQKIIQDL IAWIDEHIDQ PLNIDVVAKK SGYSKWYLQR MFRTVTHQTL
60 70 80 90 100
GDYIRQRRLL LAAVELRTTE RPIFDIAMDL GYVSQQTFSR VFRRQFDRTP

SDYRHRL
Length:107
Mass (Da):12,911
Last modified:January 23, 2007 - v2
Checksum:i7341326FBAB819D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59260.1.
BA000007 Genomic DNA. Translation: BAB38467.1.
PIRiD91259.
H86099.
RefSeqiNP_313071.1. NC_002695.1.
WP_000019358.1. NZ_LPWC01000519.1.

Genome annotation databases

EnsemblBacteriaiAAG59260; AAG59260; Z5661.
BAB38467; BAB38467; BAB38467.
GeneIDi914293.
KEGGiece:Z5661.
ecs:ECs5044.
PATRICi18359683. VBIEscCol44059_4978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59260.1.
BA000007 Genomic DNA. Translation: BAB38467.1.
PIRiD91259.
H86099.
RefSeqiNP_313071.1. NC_002695.1.
WP_000019358.1. NZ_LPWC01000519.1.

3D structure databases

ProteinModelPortaliP0A9E4.
SMRiP0A9E4. Positions 6-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z5661.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG59260; AAG59260; Z5661.
BAB38467; BAB38467; BAB38467.
GeneIDi914293.
KEGGiece:Z5661.
ecs:ECs5044.
PATRICi18359683. VBIEscCol44059_4978.

Phylogenomic databases

eggNOGiENOG4108W3Q. Bacteria.
ENOG4111IXA. LUCA.
HOGENOMiHOG000120762.
KOiK13631.
OMAiLTHWIDQ.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-5048-MONOMER.
ECOO157:SOXS-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOXS_ECO57
AccessioniPrimary (citable) accession number: P0A9E4
Secondary accession number(s): P22539
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.