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Protein

Regulatory protein SoxS

Gene

soxS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN7CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi24 – 43H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00406

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein SoxS
Gene namesi
Name:soxS
Ordered Locus Names:b4062, JW4023
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10958 soxS

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001945832 – 107Regulatory protein SoxSAdd BLAST106

Proteomic databases

PaxDbiP0A9E2
PRIDEiP0A9E2

Expressioni

Inductioni

By paraquat.

Interactioni

GO - Molecular functioni

  • bacterial-type RNA polymerase holo enzyme binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4262018, 126 interactors
DIPiDIP-10904N
IntActiP0A9E2, 10 interactors
STRINGi316385.ECDH10B_4251

Structurei

3D structure databases

ProteinModelPortaliP0A9E2
SMRiP0A9E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108W3Q Bacteria
ENOG4111IXA LUCA
HOGENOMiHOG000120762
InParanoidiP0A9E2
KOiK13631
OMAiTPTAYRH
PhylomeDBiP0A9E2

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR018060 HTH_AraC
IPR018062 HTH_AraC-typ_CS
IPR020449 Tscrpt_reg_HTH_AraC-type
PfamiView protein in Pfam
PF12833 HTH_18, 1 hit
PRINTSiPR00032 HTHARAC
SMARTiView protein in SMART
SM00342 HTH_ARAC, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00041 HTH_ARAC_FAMILY_1, 1 hit
PS01124 HTH_ARAC_FAMILY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A9E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHQKIIQDL IAWIDEHIDQ PLNIDVVAKK SGYSKWYLQR MFRTVTHQTL
60 70 80 90 100
GDYIRQRRLL LAAVELRTTE RPIFDIAMDL GYVSQQTFSR VFRRQFDRTP

SDYRHRL
Length:107
Mass (Da):12,911
Last modified:January 23, 2007 - v2
Checksum:i7341326FBAB819D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60111 Genomic DNA Translation: AAA24640.1
X59593 Genomic DNA Translation: CAA42161.1
U00006 Genomic DNA Translation: AAC43156.1
U00096 Genomic DNA Translation: AAC77032.1
AP009048 Genomic DNA Translation: BAE78064.1
PIRiJS0578
RefSeqiNP_418486.1, NC_000913.3
WP_000019358.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77032; AAC77032; b4062
BAE78064; BAE78064; BAE78064
GeneIDi948567
KEGGiecj:JW4023
eco:b4062
PATRICifig|511145.12.peg.4183

Similar proteinsi

Entry informationi

Entry nameiSOXS_ECOLI
AccessioniPrimary (citable) accession number: P0A9E2
Secondary accession number(s): P22539, Q2M6P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health