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Protein

Serine acetyltransferase

Gene

cysE

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.

Pathwayi: L-cysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-cysteine from L-serine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Serine acetyltransferase (cysE)
  2. Cysteine synthase A (cysK)
This subpathway is part of the pathway L-cysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-cysteine from L-serine, the pathway L-cysteine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Cysteine biosynthesis

Enzyme and pathway databases

SABIO-RKiP0A9D6
UniPathwayiUPA00136; UER00199

Names & Taxonomyi

Protein namesi
Recommended name:
Serine acetyltransferase (EC:2.3.1.30)
Short name:
SAT
Gene namesi
Name:cysE
Ordered Locus Names:Z5034, ECs4485
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686701 – 273Serine acetyltransferaseAdd BLAST273

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi155864.Z5034

Structurei

3D structure databases

ProteinModelPortaliP0A9D6
SMRiP0A9D6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105D7W Bacteria
COG1045 LUCA
HOGENOMiHOG000049437
KOiK00640
OMAiHPKIRHG

Family and domain databases

InterProiView protein in InterPro
IPR001451 Hexapep
IPR018357 Hexapep_transf_CS
IPR010493 Ser_AcTrfase_N
IPR005881 Ser_O-AcTrfase
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
PF06426 SATase_N, 1 hit
PIRSFiPIRSF000441 CysE, 1 hit
SMARTiView protein in SMART
SM00971 SATase_N, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR01172 cysE, 1 hit
PROSITEiView protein in PROSITE
PS00101 HEXAPEP_TRANSFERASES, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCEELEIVW NNIKAEARTL ADCEPMLASF YHATLLKHEN LGSALSYMLA
60 70 80 90 100
NKLSSPIMPA IAIREVVEEA YAADPEMIAS AACDIQAVRT RDPAVDKYST
110 120 130 140 150
PLLYLKGFHA LQAYRIGHWL WNQGRRALAI FLQNQVSVTF QVDIHPAAKI
160 170 180 190 200
GRGIMLDHAT GIVVGETAVI ENDVSILQSV TLGGTGKSGG DRHPKIREGV
210 220 230 240 250
MIGAGAKILG NIEVGRGAKI GAGSVVLQPV PPHTTAAGVP ARIVGKPDSD
260 270
KPSMDMDQHF NGINHTFEYG DGI
Length:273
Mass (Da):29,317
Last modified:July 19, 2005 - v1
Checksum:i466EB898750EF709
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58754.1
BA000007 Genomic DNA Translation: BAB37908.1
PIRiE91189
F86036
RefSeqiNP_312512.1, NC_002695.1
WP_001277561.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58754; AAG58754; Z5034
BAB37908; BAB37908; BAB37908
GeneIDi915573
KEGGiece:Z5034
ecs:ECs4485
PATRICifig|386585.9.peg.4700

Similar proteinsi

Entry informationi

Entry nameiCYSE_ECO57
AccessioniPrimary (citable) accession number: P0A9D6
Secondary accession number(s): P05796
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health