Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione S-transferase GstA

Gene

gstA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10GlutathioneBy similarity1
Binding sitei35GlutathioneBy similarity1
Binding sitei52Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei99GlutathioneBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase GstA (EC:2.5.1.18By similarity)
Gene namesi
Name:gstA
Synonyms:gst
Ordered Locus Names:Z2647, ECs2344
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859711 – 201Glutathione S-transferase GstAAdd BLAST201

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi155864.Z2647

Structurei

3D structure databases

ProteinModelPortaliP0A9D3
SMRiP0A9D3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 81GST N-terminalAdd BLAST81
Domaini87 – 201GST C-terminalAdd BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 66Glutathione bindingBy similarity2
Regioni103 – 106Glutathione bindingBy similarity4

Sequence similaritiesi

Belongs to the GST superfamily. Beta family.Curated

Phylogenomic databases

eggNOGiENOG4108K3A Bacteria
COG0625 LUCA
HOGENOMiHOG000125748
KOiK00799
OMAiYVATELH

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF13409 GST_N_2, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFYKPGAC SLASHITLRE SGKDFTLVSV DLMKKRLENG DDYFAVNPKG
60 70 80 90 100
QVPALLLDDG TLLTEGVAIM QYLADSVPDR QLLAPVNSIS RYKTIEWLNY
110 120 130 140 150
IATELHKGFT PLFRPDTPEE YKPTVRAQLE KKLQYVNEAL KDEHWICGQR
160 170 180 190 200
FTIADAYLFT VLRWAYAVKL NLEGLEHIAA FMQRMAERPE VQDALSAEGL

K
Length:201
Mass (Da):22,868
Last modified:July 19, 2005 - v1
Checksum:i6347401123B044E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG56624.1
BA000007 Genomic DNA Translation: BAB35767.1
PIRiD85770
H90921
RefSeqiNP_310371.1, NC_002695.1
WP_000765749.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG56624; AAG56624; Z2647
BAB35767; BAB35767; BAB35767
GeneIDi914142
KEGGiece:Z2647
ecs:ECs2344
PATRICifig|386585.9.peg.2453

Similar proteinsi

Entry informationi

Entry nameiGSTA_ECO57
AccessioniPrimary (citable) accession number: P0A9D3
Secondary accession number(s): P39100
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health