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P0A9D3

- GSTA_ECO57

UniProt

P0A9D3 - GSTA_ECO57

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Protein
Glutathione S-transferase GstA
Gene
gstA, gst, Z2647, ECs2344
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Glutathione By similarity
Binding sitei35 – 351Glutathione By similarity
Binding sitei52 – 521Glutathione; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei106 – 1061Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciECOL386585:GJFA-2315-MONOMER.
ECOO157:GST-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase GstA (EC:2.5.1.18)
Gene namesi
Name:gstA
Synonyms:gst
Ordered Locus Names:Z2647, ECs2344
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Glutathione S-transferase GstA
PRO_0000185971Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi155864.Z2647.

Structurei

3D structure databases

ProteinModelPortaliP0A9D3.
SMRiP0A9D3. Positions 1-201.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8181GST N-terminal
Add
BLAST
Domaini87 – 201115GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni65 – 662Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Beta family.

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125748.
KOiK00799.
OMAiNYVATEL.
OrthoDBiEOG6H1Q01.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9D3-1 [UniParc]FASTAAdd to Basket

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MKLFYKPGAC SLASHITLRE SGKDFTLVSV DLMKKRLENG DDYFAVNPKG    50
QVPALLLDDG TLLTEGVAIM QYLADSVPDR QLLAPVNSIS RYKTIEWLNY 100
IATELHKGFT PLFRPDTPEE YKPTVRAQLE KKLQYVNEAL KDEHWICGQR 150
FTIADAYLFT VLRWAYAVKL NLEGLEHIAA FMQRMAERPE VQDALSAEGL 200
K 201
Length:201
Mass (Da):22,868
Last modified:July 19, 2005 - v1
Checksum:i6347401123B044E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG56624.1.
BA000007 Genomic DNA. Translation: BAB35767.1.
PIRiD85770.
H90921.
RefSeqiNP_288071.1. NC_002655.2.
NP_310371.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG56624; AAG56624; Z2647.
BAB35767; BAB35767; BAB35767.
GeneIDi914142.
961588.
KEGGiece:Z2647.
ecs:ECs2344.
PATRICi18354016. VBIEscCol44059_2221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG56624.1 .
BA000007 Genomic DNA. Translation: BAB35767.1 .
PIRi D85770.
H90921.
RefSeqi NP_288071.1. NC_002655.2.
NP_310371.1. NC_002695.1.

3D structure databases

ProteinModelPortali P0A9D3.
SMRi P0A9D3. Positions 1-201.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z2647.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG56624 ; AAG56624 ; Z2647 .
BAB35767 ; BAB35767 ; BAB35767 .
GeneIDi 914142.
961588.
KEGGi ece:Z2647.
ecs:ECs2344.
PATRICi 18354016. VBIEscCol44059_2221.

Phylogenomic databases

eggNOGi COG0625.
HOGENOMi HOG000125748.
KOi K00799.
OMAi NYVATEL.
OrthoDBi EOG6H1Q01.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-2315-MONOMER.
ECOO157:GST-MONOMER.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiGSTA_ECO57
AccessioniPrimary (citable) accession number: P0A9D3
Secondary accession number(s): P39100
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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