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Protein

Aldose 1-epimerase

Gene

galM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.

Catalytic activityi

Alpha-D-glucose = beta-D-glucose.PROSITE-ProRule annotation

Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79SubstrateBy similarity1
Active sitei175Proton donorPROSITE-ProRule annotation1
Binding sitei245SubstrateBy similarity1
Active sitei309Proton acceptorBy similarity1

GO - Molecular functioni

  • aldose 1-epimerase activity Source: EcoCyc
  • carbohydrate binding Source: InterPro

GO - Biological processi

  • galactose catabolic process via UDP-galactose Source: EcoCyc
  • glucose metabolic process Source: GO_Central

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BioCyciEcoCyc:ALDOSE1EPIM-MONOMER
MetaCyc:ALDOSE1EPIM-MONOMER
BRENDAi5.1.3.B1 2026
SABIO-RKiP0A9C3
UniPathwayiUPA00242

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose 1-epimerase (EC:5.1.3.3)
Alternative name(s):
Galactose mutarotase
Type-1 mutarotase
Gene namesi
Name:galM
Ordered Locus Names:b0756, JW0739
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11698 galM

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001974431 – 346Aldose 1-epimeraseAdd BLAST346

Proteomic databases

PaxDbiP0A9C3
PRIDEiP0A9C3

2D gel databases

SWISS-2DPAGEiP0A9C3

Interactioni

Protein-protein interaction databases

BioGridi4261710, 25 interactors
DIPiDIP-35901N
IntActiP0A9C3, 4 interactors
STRINGi316385.ECDH10B_0823

Structurei

3D structure databases

ProteinModelPortaliP0A9C3
SMRiP0A9C3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldose epimerase family.Curated

Phylogenomic databases

eggNOGiENOG4105ENN Bacteria
COG2017 LUCA
HOGENOMiHOG000072798
InParanoidiP0A9C3
KOiK01785
OMAiATWLSCK
PhylomeDBiP0A9C3

Family and domain databases

Gene3Di2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR018052 Ald1_epimerase_CS
IPR013458 Ald_epimerase_bac
IPR015443 Aldose_1-epimerase
IPR008183 Aldose_1/G6P_1-epimerase
IPR011013 Gal_mutarotase_sf_dom
IPR014718 GH-type_carb-bd
PfamiView protein in Pfam
PF01263 Aldose_epim, 1 hit
PIRSFiPIRSF005096 GALM, 1 hit
SUPFAMiSSF74650 SSF74650, 1 hit
TIGRFAMsiTIGR02636 galM_Leloir, 1 hit
PROSITEiView protein in PROSITE
PS00545 ALDOSE_1_EPIMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A9C3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNETPALAP DGQPYRLLTL RNNAGMVVTL MDWGATLLSA RIPLSDGSVR
60 70 80 90 100
EALLGCASPE CYQDQAAFLG ASIGRYANRI ANSRYTFDGE TVTLSPSQGV
110 120 130 140 150
NQLHGGPEGF DKRRWQIVNQ NDRQVLFALS SDDGDQGFPG NLGATVQYRL
160 170 180 190 200
TDDNRISITY RATVDKPCPV NMTNHVYFNL DGEQSDVRNH KLQILADEYL
210 220 230 240 250
PVDEGGIPHD GLKSVAGTSF DFRSAKIIAS EFLADDDQRK VKGYDHAFLL
260 270 280 290 300
QAKGDGKKVA AHVWSADEKL QLKVYTTAPA LQFYSGNFLG GTPSRGTEPY
310 320 330 340
ADWQGLALES EFLPDSPNHP EWPQPDCFLR PGEEYSSLTE YQFIAE
Length:346
Mass (Da):38,190
Last modified:July 19, 2005 - v1
Checksum:i4373732BAEA83E1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13636 Genomic DNA Translation: AAB17020.1
U00096 Genomic DNA Translation: AAC73843.1
AP009048 Genomic DNA Translation: BAA35418.1
PIRiD64811
RefSeqiNP_415277.1, NC_000913.3
WP_000931389.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73843; AAC73843; b0756
BAA35418; BAA35418; BAA35418
GeneIDi944943
KEGGiecj:JW0739
eco:b0756
PATRICifig|1411691.4.peg.1522

Similar proteinsi

Entry informationi

Entry nameiGALM_ECOLI
AccessioniPrimary (citable) accession number: P0A9C3
Secondary accession number(s): P40681
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health