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P0A9C2

- GLPA_SHIFL

UniProt

P0A9C2 - GLPA_SHIFL

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Protein
Anaerobic glycerol-3-phosphate dehydrogenase subunit A
Gene
glpA, SF2323, S2456
Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor By similarity.

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FAD By similarity.
FMN By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 3829FAD Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro
  3. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycerol catabolic process Source: UniProtKB-UniPathway
  2. glycerol-3-phosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic glycerol-3-phosphate dehydrogenase subunit A (EC:1.1.5.3)
Short name:
G-3-P dehydrogenase
Gene namesi
Name:glpA
Ordered Locus Names:SF2323, S2456
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

Subcellular locationi

Cell inner membrane; Peripheral membrane protein By similarity
Note: Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase By similarity.

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Anaerobic glycerol-3-phosphate dehydrogenase subunit A
PRO_0000126096Add
BLAST

Interactioni

Subunit structurei

Composed of a catalytic GlpA/B dimer and of membrane bound GlpC By similarity.

Protein-protein interaction databases

STRINGi198214.SF2323.

Structurei

3D structure databases

ProteinModelPortaliP0A9C2.
SMRiP0A9C2. Positions 5-365.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0578.
HOGENOMiHOG000004814.
KOiK00111.
OrthoDBiEOG651SR7.

Family and domain databases

InterProiIPR007419. BFD-like_2Fe2S-bd_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
IPR017752. G3P_DH_GlpA_su.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF04324. Fer2_BFD. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
TIGRFAMsiTIGR03377. glycerol3P_GlpA. 1 hit.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9C2-1 [UniParc]FASTAAdd to Basket

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MKTRDSQSSD VIIIGGGATG AGIARDCALR GLRVILVERH DIATGATGRN    50
HGLLHSGARY AVTDAESARE CISENQILKR IARHCVEPTN GLFITLPEDD 100
LSFQATFIRA CEEAGISAEA IDPQQARIIE PAVNPALIGA VKVPDGTVDP 150
FRLTAANMLD AKEHGAVILT AHEVTGLIRE GATVCGVRVR NHLTGETQAL 200
HAPVVVNAAG IWGQHIAEYA DLRIRMFPAK GSLLIMDHRI NQHVINRCRK 250
PSDADILVPG DTISLIGTTS LRIDYNEIDD NRVTAEEVDI LLREGEKLAP 300
VMAKTRILRA YSGVRPLVAS DDDPSGRNVS RGIVLLDHAE RDGLDGFITI 350
TGGKLMTYRL MAEWATDAVC RKLGNTRPCT TADLALPGSQ EPAEVTLRKV 400
ISLPAPLRGS AVYRHGDRTP AWLSEGRLHR SLVCECEAVT AGEVQYAVEN 450
LNVNSLLDLR RRTRVGMGTC QGELCACRAA GLLQRFNVTT SAQSIEQLST 500
FLNERWKGVQ PIAWGDALRE SEFTRWVYQG LCGLEKEQKD AL 542
Length:542
Mass (Da):58,958
Last modified:July 19, 2005 - v1
Checksum:iE5C803F89E912E0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN43838.2.
AE014073 Genomic DNA. Translation: AAP17656.1.
RefSeqiNP_708131.2. NC_004337.2.
NP_837846.1. NC_004741.1.

Genome annotation databases

EnsemblBacteriaiAAN43838; AAN43838; SF2323.
AAP17656; AAP17656; S2456.
GeneIDi1025493.
1078747.
KEGGisfl:SF2323.
sfx:S2456.
PATRICi18706497. VBIShiFle31049_2724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN43838.2 .
AE014073 Genomic DNA. Translation: AAP17656.1 .
RefSeqi NP_708131.2. NC_004337.2.
NP_837846.1. NC_004741.1.

3D structure databases

ProteinModelPortali P0A9C2.
SMRi P0A9C2. Positions 5-365.
ModBasei Search...

Protein-protein interaction databases

STRINGi 198214.SF2323.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN43838 ; AAN43838 ; SF2323 .
AAP17656 ; AAP17656 ; S2456 .
GeneIDi 1025493.
1078747.
KEGGi sfl:SF2323.
sfx:S2456.
PATRICi 18706497. VBIShiFle31049_2724.

Phylogenomic databases

eggNOGi COG0578.
HOGENOMi HOG000004814.
KOi K00111.
OrthoDBi EOG651SR7.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00673 .

Family and domain databases

InterProi IPR007419. BFD-like_2Fe2S-bd_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
IPR017752. G3P_DH_GlpA_su.
[Graphical view ]
Pfami PF01266. DAO. 1 hit.
PF04324. Fer2_BFD. 1 hit.
[Graphical view ]
PRINTSi PR01001. FADG3PDH.
TIGRFAMsi TIGR03377. glycerol3P_GlpA. 1 hit.
PROSITEi PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiGLPA_SHIFL
AccessioniPrimary (citable) accession number: P0A9C2
Secondary accession number(s): P13032, P78238
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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