Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0A9C2

- GLPA_SHIFL

UniProt

P0A9C2 - GLPA_SHIFL

Protein

Anaerobic glycerol-3-phosphate dehydrogenase subunit A

Gene

glpA

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor By similarity.By similarity

    Catalytic activityi

    sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

    Cofactori

    FAD.By similarity
    FMN.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 3829FADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. FMN binding Source: InterPro
    3. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: InterPro
    2. glycerol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00618; UER00673.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anaerobic glycerol-3-phosphate dehydrogenase subunit A (EC:1.1.5.3)
    Short name:
    G-3-P dehydrogenase
    Gene namesi
    Name:glpA
    Ordered Locus Names:SF2323, S2456
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Peripheral membrane protein By similarity
    Note: Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase.By similarity

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 542542Anaerobic glycerol-3-phosphate dehydrogenase subunit APRO_0000126096Add
    BLAST

    Interactioni

    Subunit structurei

    Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.By similarity

    Protein-protein interaction databases

    STRINGi198214.SF2323.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A9C2.
    SMRiP0A9C2. Positions 5-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0578.
    HOGENOMiHOG000004814.
    KOiK00111.
    OrthoDBiEOG651SR7.

    Family and domain databases

    InterProiIPR007419. BFD-like_2Fe2S-bd_dom.
    IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    IPR017752. G3P_DH_GlpA_su.
    [Graphical view]
    PfamiPF01266. DAO. 1 hit.
    PF04324. Fer2_BFD. 1 hit.
    [Graphical view]
    PRINTSiPR01001. FADG3PDH.
    TIGRFAMsiTIGR03377. glycerol3P_GlpA. 1 hit.
    PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A9C2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTRDSQSSD VIIIGGGATG AGIARDCALR GLRVILVERH DIATGATGRN    50
    HGLLHSGARY AVTDAESARE CISENQILKR IARHCVEPTN GLFITLPEDD 100
    LSFQATFIRA CEEAGISAEA IDPQQARIIE PAVNPALIGA VKVPDGTVDP 150
    FRLTAANMLD AKEHGAVILT AHEVTGLIRE GATVCGVRVR NHLTGETQAL 200
    HAPVVVNAAG IWGQHIAEYA DLRIRMFPAK GSLLIMDHRI NQHVINRCRK 250
    PSDADILVPG DTISLIGTTS LRIDYNEIDD NRVTAEEVDI LLREGEKLAP 300
    VMAKTRILRA YSGVRPLVAS DDDPSGRNVS RGIVLLDHAE RDGLDGFITI 350
    TGGKLMTYRL MAEWATDAVC RKLGNTRPCT TADLALPGSQ EPAEVTLRKV 400
    ISLPAPLRGS AVYRHGDRTP AWLSEGRLHR SLVCECEAVT AGEVQYAVEN 450
    LNVNSLLDLR RRTRVGMGTC QGELCACRAA GLLQRFNVTT SAQSIEQLST 500
    FLNERWKGVQ PIAWGDALRE SEFTRWVYQG LCGLEKEQKD AL 542
    Length:542
    Mass (Da):58,958
    Last modified:July 19, 2005 - v1
    Checksum:iE5C803F89E912E0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN43838.2.
    AE014073 Genomic DNA. Translation: AAP17656.1.
    RefSeqiNP_708131.2. NC_004337.2.
    NP_837846.1. NC_004741.1.

    Genome annotation databases

    EnsemblBacteriaiAAN43838; AAN43838; SF2323.
    AAP17656; AAP17656; S2456.
    GeneIDi1025493.
    1078747.
    KEGGisfl:SF2323.
    sfx:S2456.
    PATRICi18706497. VBIShiFle31049_2724.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN43838.2 .
    AE014073 Genomic DNA. Translation: AAP17656.1 .
    RefSeqi NP_708131.2. NC_004337.2.
    NP_837846.1. NC_004741.1.

    3D structure databases

    ProteinModelPortali P0A9C2.
    SMRi P0A9C2. Positions 5-365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.SF2323.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN43838 ; AAN43838 ; SF2323 .
    AAP17656 ; AAP17656 ; S2456 .
    GeneIDi 1025493.
    1078747.
    KEGGi sfl:SF2323.
    sfx:S2456.
    PATRICi 18706497. VBIShiFle31049_2724.

    Phylogenomic databases

    eggNOGi COG0578.
    HOGENOMi HOG000004814.
    KOi K00111.
    OrthoDBi EOG651SR7.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00673 .

    Family and domain databases

    InterProi IPR007419. BFD-like_2Fe2S-bd_dom.
    IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    IPR017752. G3P_DH_GlpA_su.
    [Graphical view ]
    Pfami PF01266. DAO. 1 hit.
    PF04324. Fer2_BFD. 1 hit.
    [Graphical view ]
    PRINTSi PR01001. FADG3PDH.
    TIGRFAMsi TIGR03377. glycerol3P_GlpA. 1 hit.
    PROSITEi PS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700930 / 2457T / Serotype 2a.

    Entry informationi

    Entry nameiGLPA_SHIFL
    AccessioniPrimary (citable) accession number: P0A9C2
    Secondary accession number(s): P13032, P78238
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3