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P0A9C1

- GLPA_ECO57

UniProt

P0A9C1 - GLPA_ECO57

Protein

Anaerobic glycerol-3-phosphate dehydrogenase subunit A

Gene

glpA

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor By similarity.By similarity

    Catalytic activityi

    sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

    Cofactori

    FAD.By similarity
    FMN.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 3829FADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. FMN binding Source: InterPro
    3. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: InterPro
    2. glycerol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-3078-MONOMER.
    ECOO157:GLPA-MONOMER.
    UniPathwayiUPA00618; UER00673.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anaerobic glycerol-3-phosphate dehydrogenase subunit A (EC:1.1.5.3)
    Short name:
    G-3-P dehydrogenase
    Gene namesi
    Name:glpA
    Ordered Locus Names:Z3499, ECs3126
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Peripheral membrane protein By similarity
    Note: Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase.By similarity

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 542542Anaerobic glycerol-3-phosphate dehydrogenase subunit APRO_0000126094Add
    BLAST

    Interactioni

    Subunit structurei

    Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.By similarity

    Protein-protein interaction databases

    STRINGi155864.Z3499.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A9C1.
    SMRiP0A9C1. Positions 5-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0578.
    HOGENOMiHOG000004814.
    KOiK00111.
    OMAiQIDNMEV.
    OrthoDBiEOG651SR7.

    Family and domain databases

    InterProiIPR007419. BFD-like_2Fe2S-bd_dom.
    IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    IPR017752. G3P_DH_GlpA_su.
    [Graphical view]
    PfamiPF01266. DAO. 1 hit.
    PF04324. Fer2_BFD. 1 hit.
    [Graphical view]
    PRINTSiPR01001. FADG3PDH.
    TIGRFAMsiTIGR03377. glycerol3P_GlpA. 1 hit.
    PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A9C1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTRDSQSSD VIIIGGGATG AGIARDCALR GLRVILVERH DIATGATGRN    50
    HGLLHSGARY AVTDAESARE CISENQILKR IARHCVEPTN GLFITLPEDD 100
    LSFQATFIRA CEEAGISAEA IDPQQARIIE PAVNPALIGA VKVPDGTVDP 150
    FRLTAANMLD AKEHGAVILT AHEVTGLIRE GATVCGVRVR NHLTGETQAL 200
    HAPVVVNAAG IWGQHIAEYA DLRIRMFPAK GSLLIMDHRI NQHVINRCRK 250
    PSDADILVPG DTISLIGTTS LRIDYNEIDD NRVTAEEVDI LLREGEKLAP 300
    VMAKTRILRA YSGVRPLVAS DDDPSGRNVS RGIVLLDHAE RDGLDGFITI 350
    TGGKLMTYRL MAEWATDAVC RKLGNTRPCT TADLALPGSQ EPAEVTLRKV 400
    ISLPAPLRGS AVYRHGDRTP AWLSEGRLHR SLVCECEAVT AGEVQYAVEN 450
    LNVNSLLDLR RRTRVGMGTC QGELCACRAA GLLQRFNVTT SAQSIEQLST 500
    FLNERWKGVQ PIAWGDALRE SEFTRWVYQG LCGLEKEQKD AL 542
    Length:542
    Mass (Da):58,958
    Last modified:July 19, 2005 - v1
    Checksum:iE5C803F89E912E0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57372.1.
    BA000007 Genomic DNA. Translation: BAB36549.1.
    PIRiF91019.
    RefSeqiNP_288817.1. NC_002655.2.
    NP_311153.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG57372; AAG57372; Z3499.
    BAB36549; BAB36549; BAB36549.
    GeneIDi916834.
    959442.
    KEGGiece:Z3499.
    ecs:ECs3126.
    PATRICi18355636. VBIEscCol44059_3019.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57372.1 .
    BA000007 Genomic DNA. Translation: BAB36549.1 .
    PIRi F91019.
    RefSeqi NP_288817.1. NC_002655.2.
    NP_311153.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali P0A9C1.
    SMRi P0A9C1. Positions 5-365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z3499.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG57372 ; AAG57372 ; Z3499 .
    BAB36549 ; BAB36549 ; BAB36549 .
    GeneIDi 916834.
    959442.
    KEGGi ece:Z3499.
    ecs:ECs3126.
    PATRICi 18355636. VBIEscCol44059_3019.

    Phylogenomic databases

    eggNOGi COG0578.
    HOGENOMi HOG000004814.
    KOi K00111.
    OMAi QIDNMEV.
    OrthoDBi EOG651SR7.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00673 .
    BioCyci ECOL386585:GJFA-3078-MONOMER.
    ECOO157:GLPA-MONOMER.

    Family and domain databases

    InterProi IPR007419. BFD-like_2Fe2S-bd_dom.
    IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    IPR017752. G3P_DH_GlpA_su.
    [Graphical view ]
    Pfami PF01266. DAO. 1 hit.
    PF04324. Fer2_BFD. 1 hit.
    [Graphical view ]
    PRINTSi PR01001. FADG3PDH.
    TIGRFAMsi TIGR03377. glycerol3P_GlpA. 1 hit.
    PROSITEi PS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiGLPA_ECO57
    AccessioniPrimary (citable) accession number: P0A9C1
    Secondary accession number(s): P13032, P78238
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3