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P0A9C1

- GLPA_ECO57

UniProt

P0A9C1 - GLPA_ECO57

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Protein

Anaerobic glycerol-3-phosphate dehydrogenase subunit A

Gene
glpA, Z3499, ECs3126
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor By similarity.

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FAD By similarity.
FMN By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 3829FAD Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. FMN binding Source: InterPro
  3. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: InterPro
  2. glycerol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3078-MONOMER.
ECOO157:GLPA-MONOMER.
UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic glycerol-3-phosphate dehydrogenase subunit A (EC:1.1.5.3)
Short name:
G-3-P dehydrogenase
Gene namesi
Name:glpA
Ordered Locus Names:Z3499, ECs3126
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

Subcellular locationi

Cell inner membrane; Peripheral membrane protein By similarity
Note: Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase By similarity.

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Anaerobic glycerol-3-phosphate dehydrogenase subunit APRO_0000126094Add
BLAST

Interactioni

Subunit structurei

Composed of a catalytic GlpA/B dimer and of membrane bound GlpC By similarity.

Protein-protein interaction databases

STRINGi155864.Z3499.

Structurei

3D structure databases

ProteinModelPortaliP0A9C1.
SMRiP0A9C1. Positions 5-365.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0578.
HOGENOMiHOG000004814.
KOiK00111.
OMAiQIDNMEV.
OrthoDBiEOG651SR7.

Family and domain databases

InterProiIPR007419. BFD-like_2Fe2S-bd_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
IPR017752. G3P_DH_GlpA_su.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF04324. Fer2_BFD. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
TIGRFAMsiTIGR03377. glycerol3P_GlpA. 1 hit.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A9C1-1 [UniParc]FASTAAdd to Basket

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MKTRDSQSSD VIIIGGGATG AGIARDCALR GLRVILVERH DIATGATGRN    50
HGLLHSGARY AVTDAESARE CISENQILKR IARHCVEPTN GLFITLPEDD 100
LSFQATFIRA CEEAGISAEA IDPQQARIIE PAVNPALIGA VKVPDGTVDP 150
FRLTAANMLD AKEHGAVILT AHEVTGLIRE GATVCGVRVR NHLTGETQAL 200
HAPVVVNAAG IWGQHIAEYA DLRIRMFPAK GSLLIMDHRI NQHVINRCRK 250
PSDADILVPG DTISLIGTTS LRIDYNEIDD NRVTAEEVDI LLREGEKLAP 300
VMAKTRILRA YSGVRPLVAS DDDPSGRNVS RGIVLLDHAE RDGLDGFITI 350
TGGKLMTYRL MAEWATDAVC RKLGNTRPCT TADLALPGSQ EPAEVTLRKV 400
ISLPAPLRGS AVYRHGDRTP AWLSEGRLHR SLVCECEAVT AGEVQYAVEN 450
LNVNSLLDLR RRTRVGMGTC QGELCACRAA GLLQRFNVTT SAQSIEQLST 500
FLNERWKGVQ PIAWGDALRE SEFTRWVYQG LCGLEKEQKD AL 542
Length:542
Mass (Da):58,958
Last modified:July 19, 2005 - v1
Checksum:iE5C803F89E912E0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG57372.1.
BA000007 Genomic DNA. Translation: BAB36549.1.
PIRiF91019.
RefSeqiNP_288817.1. NC_002655.2.
NP_311153.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG57372; AAG57372; Z3499.
BAB36549; BAB36549; BAB36549.
GeneIDi916834.
959442.
KEGGiece:Z3499.
ecs:ECs3126.
PATRICi18355636. VBIEscCol44059_3019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG57372.1 .
BA000007 Genomic DNA. Translation: BAB36549.1 .
PIRi F91019.
RefSeqi NP_288817.1. NC_002655.2.
NP_311153.1. NC_002695.1.

3D structure databases

ProteinModelPortali P0A9C1.
SMRi P0A9C1. Positions 5-365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z3499.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG57372 ; AAG57372 ; Z3499 .
BAB36549 ; BAB36549 ; BAB36549 .
GeneIDi 916834.
959442.
KEGGi ece:Z3499.
ecs:ECs3126.
PATRICi 18355636. VBIEscCol44059_3019.

Phylogenomic databases

eggNOGi COG0578.
HOGENOMi HOG000004814.
KOi K00111.
OMAi QIDNMEV.
OrthoDBi EOG651SR7.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00673 .
BioCyci ECOL386585:GJFA-3078-MONOMER.
ECOO157:GLPA-MONOMER.

Family and domain databases

InterProi IPR007419. BFD-like_2Fe2S-bd_dom.
IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
IPR017752. G3P_DH_GlpA_su.
[Graphical view ]
Pfami PF01266. DAO. 1 hit.
PF04324. Fer2_BFD. 1 hit.
[Graphical view ]
PRINTSi PR01001. FADG3PDH.
TIGRFAMsi TIGR03377. glycerol3P_GlpA. 1 hit.
PROSITEi PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiGLPA_ECO57
AccessioniPrimary (citable) accession number: P0A9C1
Secondary accession number(s): P13032, P78238
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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