ID GLPA_ECOLI Reviewed; 542 AA. AC P0A9C0; P13032; P78238; DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot. DT 19-JUL-2005, sequence version 1. DT 16-JUN-2009, entry version 40. DE RecName: Full=Anaerobic glycerol-3-phosphate dehydrogenase subunit A; DE Short=G-3-P dehydrogenase; DE EC=1.1.5.3; GN Name=glpA; OrderedLocusNames=b2241, JW2235; OS Escherichia coli (strain K12). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-10. RC STRAIN=K12; RX MEDLINE=88227815; PubMed=3286606; RA Cole S.T., Eiglmeier K., Ahmed S., Honore N., Elmes L., Anderson W.F., RA Weiner J.H.; RT "Nucleotide sequence and gene-polypeptide relationships of the glpABC RT operon encoding the anaerobic sn-glycerol-3-phosphate dehydrogenase of RT Escherichia coli K-12."; RL J. Bacteriol. 170:2448-2456(1988). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX MEDLINE=97349980; PubMed=9205837; DOI=10.1093/dnares/4.2.91; RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., RA Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., RA Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., RA Oshima T., Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., RA Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., RA Yamagata S., Horiuchi T.; RT "Construction of a contiguous 874-kb sequence of the Escherichia coli- RT K12 genome corresponding to 50.0-68.8 min on the linkage map and RT analysis of its sequence features."; RL DNA Res. 4:91-113(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., RA Mau B., Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1474(1997). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains RT MG1655 and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). CC -!- FUNCTION: Conversion of glycerol 3-phosphate to dihydroxyacetone. CC Uses fumarate or nitrate as electron acceptor. CC -!- CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + a quinone = CC glycerone phosphate + a quinol. CC -!- COFACTOR: FAD. CC -!- COFACTOR: FMN. CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol CC kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate CC (anaerobic route): step 1/1. CC -!- SUBUNIT: Composed of a catalytic glpA/B dimer and of membrane CC bound glpC. CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane CC protein. Note=Loosely bound to the cytoplasmic membrane often CC occurring in vesicles associated with fumarate reductase. CC -!- SIMILARITY: Belongs to the FAD-dependent glycerol-3-phosphate CC dehydrogenase family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M20938; AAA83864.1; -; Genomic_DNA. DR EMBL; U00096; AAC75301.1; -; Genomic_DNA. DR EMBL; AP009048; BAA16060.1; -; Genomic_DNA. DR PIR; A32006; DEECNA. DR RefSeq; AP_002838.1; -. DR RefSeq; NP_416744.1; -. DR GeneID; 946713; -. DR GenomeReviews; AP009048_GR; JW2235. DR GenomeReviews; U00096_GR; b2241. DR KEGG; ecj:JW2235; -. DR KEGG; eco:b2241; -. DR EchoBASE; EB0386; -. DR EcoGene; EG10391; glpA. DR HOGENOM; P0A9C0; -. DR OMA; P0A9C0; KTFLESC. DR BioCyc; EcoCyc:ANGLYC3PDEHYDROGSUBUNITA-MON; -. DR BioCyc; MetaCyc:ANGLYC3PDEHYDROGSUBUNITA-MON; -. DR GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0050660; F:FAD binding; IEA:InterPro. DR GO; GO:0010181; F:FMN binding; IEA:InterPro. DR GO; GO:0004368; F:glycerol-3-phosphate dehydrogenase activity; IEA:InterPro. DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:InterPro. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR GO; GO:0046174; P:polyol catabolic process; IEA:InterPro. DR InterPro; IPR017752; Anaerobic_glycerol3P_DH_asu. DR InterPro; IPR007419; BFD_Fer2_bd. DR InterPro; IPR000447; FAD-dep_Gly3P_DH. DR InterPro; IPR006076; FAD-dep_OxRdtase. DR Pfam; PF01266; DAO; 1. DR Pfam; PF04324; Fer2_BFD; 1. DR PRINTS; PR01001; FADG3PDH. DR TIGRFAMs; TIGR03377; glycerol3P_GlpA; 1. DR PROSITE; PS00977; FAD_G3PDH_1; 1. DR PROSITE; PS00978; FAD_G3PDH_2; 1. PE 1: Evidence at protein level; KW Cell inner membrane; Cell membrane; Complete proteome; KW Direct protein sequencing; FAD; Flavoprotein; Membrane; KW Oxidoreductase. FT CHAIN 1 542 Anaerobic glycerol-3-phosphate FT dehydrogenase subunit A. FT /FTId=PRO_0000126093. FT NP_BIND 10 38 FAD (Potential). FT CONFLICT 329 329 V -> L (in Ref. 1; AAA83864). SQ SEQUENCE 542 AA; 58958 MW; E5C803F89E912E0E CRC64; MKTRDSQSSD VIIIGGGATG AGIARDCALR GLRVILVERH DIATGATGRN HGLLHSGARY AVTDAESARE CISENQILKR IARHCVEPTN GLFITLPEDD LSFQATFIRA CEEAGISAEA IDPQQARIIE PAVNPALIGA VKVPDGTVDP FRLTAANMLD AKEHGAVILT AHEVTGLIRE GATVCGVRVR NHLTGETQAL HAPVVVNAAG IWGQHIAEYA DLRIRMFPAK GSLLIMDHRI NQHVINRCRK PSDADILVPG DTISLIGTTS LRIDYNEIDD NRVTAEEVDI LLREGEKLAP VMAKTRILRA YSGVRPLVAS DDDPSGRNVS RGIVLLDHAE RDGLDGFITI TGGKLMTYRL MAEWATDAVC RKLGNTRPCT TADLALPGSQ EPAEVTLRKV ISLPAPLRGS AVYRHGDRTP AWLSEGRLHR SLVCECEAVT AGEVQYAVEN LNVNSLLDLR RRTRVGMGTC QGELCACRAA GLLQRFNVTT SAQSIEQLST FLNERWKGVQ PIAWGDALRE SEFTRWVYQG LCGLEKEQKD AL //