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Protein

Ferric uptake regulation protein

Gene

fur

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a global negative controlling element, employing Fe2+ as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi33 – 331ZincBy similarity
Metal bindingi81 – 811ZincBy similarity
Metal bindingi87 – 871IronBy similarity
Metal bindingi89 – 891IronBy similarity
Metal bindingi90 – 901ZincBy similarity
Metal bindingi93 – 931Zinc
Metal bindingi96 – 961Zinc
Metal bindingi101 – 1011ZincBy similarity
Metal bindingi108 – 1081IronBy similarity
Metal bindingi125 – 1251IronBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:PD00260.
ECOL316407:JW0669-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric uptake regulation protein
Short name:
Ferric uptake regulator
Gene namesi
Name:fur
Ordered Locus Names:b0683, JW0669
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10359. fur.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 148147Ferric uptake regulation proteinPRO_0000095550Add
BLAST

Proteomic databases

EPDiP0A9A9.
PaxDbiP0A9A9.
PRIDEiP0A9A9.

2D gel databases

SWISS-2DPAGEP0A9A9.

Expressioni

Gene expression databases

CollecTFiEXPREG_000007c0.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi4262110. 24 interactions.
849672. 1 interaction.
DIPiDIP-31858N.
IntActiP0A9A9. 50 interactions.
MINTiMINT-1312814.
STRINGi511145.b0683.

Structurei

Secondary structure

1
148
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 107Combined sources
Helixi17 – 2610Combined sources
Helixi29 – 313Combined sources
Beta strandi32 – 343Combined sources
Helixi36 – 4510Combined sources
Helixi52 – 6413Combined sources
Beta strandi67 – 726Combined sources
Helixi74 – 763Combined sources
Beta strandi78 – 825Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FU4X-ray1.80A/B1-83[»]
ProteinModelPortaliP0A9A9.
SMRiP0A9A9. Positions 3-83.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9A9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 8483DNA-bindingBy similarityAdd
BLAST
Regioni85 – 14864DimerizationBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi86 – 905His-rich

Sequence similaritiesi

Belongs to the Fur family.Curated

Phylogenomic databases

eggNOGiENOG41090R7. Bacteria.
COG0735. LUCA.
HOGENOMiHOG000014144.
InParanoidiP0A9A9.
KOiK03711.
OMAiDERSDIG.
PhylomeDBiP0A9A9.

Family and domain databases

CDDicd07153. Fur_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR002481. FUR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01475. FUR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A9A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNNTALKK AGLKVTLPRL KILEVLQEPD NHHVSAEDLY KRLIDMGEEI
60 70 80 90 100
GLATVYRVLN QFDDAGIVTR HNFEGGKSVF ELTQQHHHDH LICLDCGKVI
110 120 130 140
EFSDDSIEAR QREIAAKHGI RLTNHSLYLY GHCAEGDCRE DEHAHEGK
Length:148
Mass (Da):16,795
Last modified:April 1, 1988 - v1
Checksum:iB868360513489DD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02589 Genomic DNA. Translation: CAA26429.1.
U00096 Genomic DNA. Translation: AAC73777.1.
AP009048 Genomic DNA. Translation: BAA35331.1.
PIRiS07308.
RefSeqiNP_415209.1. NC_000913.3.
WP_000131702.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73777; AAC73777; b0683.
BAA35331; BAA35331; BAA35331.
GeneIDi945295.
KEGGiecj:JW0669.
eco:b0683.
PATRICi32116559. VBIEscCol129921_0712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02589 Genomic DNA. Translation: CAA26429.1.
U00096 Genomic DNA. Translation: AAC73777.1.
AP009048 Genomic DNA. Translation: BAA35331.1.
PIRiS07308.
RefSeqiNP_415209.1. NC_000913.3.
WP_000131702.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FU4X-ray1.80A/B1-83[»]
ProteinModelPortaliP0A9A9.
SMRiP0A9A9. Positions 3-83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262110. 24 interactions.
849672. 1 interaction.
DIPiDIP-31858N.
IntActiP0A9A9. 50 interactions.
MINTiMINT-1312814.
STRINGi511145.b0683.

2D gel databases

SWISS-2DPAGEP0A9A9.

Proteomic databases

EPDiP0A9A9.
PaxDbiP0A9A9.
PRIDEiP0A9A9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73777; AAC73777; b0683.
BAA35331; BAA35331; BAA35331.
GeneIDi945295.
KEGGiecj:JW0669.
eco:b0683.
PATRICi32116559. VBIEscCol129921_0712.

Organism-specific databases

EchoBASEiEB0354.
EcoGeneiEG10359. fur.

Phylogenomic databases

eggNOGiENOG41090R7. Bacteria.
COG0735. LUCA.
HOGENOMiHOG000014144.
InParanoidiP0A9A9.
KOiK03711.
OMAiDERSDIG.
PhylomeDBiP0A9A9.

Enzyme and pathway databases

BioCyciEcoCyc:PD00260.
ECOL316407:JW0669-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A9A9.
PROiP0A9A9.

Gene expression databases

CollecTFiEXPREG_000007c0.

Family and domain databases

CDDicd07153. Fur_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR002481. FUR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01475. FUR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUR_ECOLI
AccessioniPrimary (citable) accession number: P0A9A9
Secondary accession number(s): P06975
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Activated by cadmium, cobalt, copper, and manganese ions, but not zinc ions.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.