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Protein

Ferric uptake regulation protein

Gene

fur

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a global negative controlling element, employing Fe2+ as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi33ZincBy similarity1
Metal bindingi81ZincBy similarity1
Metal bindingi87IronBy similarity1
Metal bindingi89IronBy similarity1
Metal bindingi90ZincBy similarity1
Metal bindingi93Zinc1
Metal bindingi96Zinc1
Metal bindingi101ZincBy similarity1
Metal bindingi108IronBy similarity1
Metal bindingi125IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:PD00260.
ECOL316407:JW0669-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric uptake regulation protein
Short name:
Ferric uptake regulator
Gene namesi
Name:fur
Ordered Locus Names:b0683, JW0669
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10359. fur.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000955502 – 148Ferric uptake regulation proteinAdd BLAST147

Proteomic databases

EPDiP0A9A9.
PaxDbiP0A9A9.
PRIDEiP0A9A9.

2D gel databases

SWISS-2DPAGEP0A9A9.

Expressioni

Gene expression databases

CollecTFiEXPREG_000007c0.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi4262110. 24 interactors.
849672. 1 interactor.
DIPiDIP-31858N.
IntActiP0A9A9. 50 interactors.
MINTiMINT-1312814.
STRINGi511145.b0683.

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 10Combined sources7
Helixi17 – 26Combined sources10
Helixi29 – 31Combined sources3
Beta strandi32 – 34Combined sources3
Helixi36 – 45Combined sources10
Helixi52 – 64Combined sources13
Beta strandi67 – 72Combined sources6
Helixi74 – 76Combined sources3
Beta strandi78 – 82Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FU4X-ray1.80A/B1-83[»]
ProteinModelPortaliP0A9A9.
SMRiP0A9A9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A9A9.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 84DNA-bindingBy similarityAdd BLAST83
Regioni85 – 148DimerizationBy similarityAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 90His-rich5

Sequence similaritiesi

Belongs to the Fur family.Curated

Phylogenomic databases

eggNOGiENOG41090R7. Bacteria.
COG0735. LUCA.
HOGENOMiHOG000014144.
InParanoidiP0A9A9.
KOiK03711.
OMAiDERSDIG.
PhylomeDBiP0A9A9.

Family and domain databases

CDDicd07153. Fur_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR002481. FUR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01475. FUR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A9A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNNTALKK AGLKVTLPRL KILEVLQEPD NHHVSAEDLY KRLIDMGEEI
60 70 80 90 100
GLATVYRVLN QFDDAGIVTR HNFEGGKSVF ELTQQHHHDH LICLDCGKVI
110 120 130 140
EFSDDSIEAR QREIAAKHGI RLTNHSLYLY GHCAEGDCRE DEHAHEGK
Length:148
Mass (Da):16,795
Last modified:April 1, 1988 - v1
Checksum:iB868360513489DD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02589 Genomic DNA. Translation: CAA26429.1.
U00096 Genomic DNA. Translation: AAC73777.1.
AP009048 Genomic DNA. Translation: BAA35331.1.
PIRiS07308.
RefSeqiNP_415209.1. NC_000913.3.
WP_000131702.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73777; AAC73777; b0683.
BAA35331; BAA35331; BAA35331.
GeneIDi945295.
KEGGiecj:JW0669.
eco:b0683.
PATRICi32116559. VBIEscCol129921_0712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02589 Genomic DNA. Translation: CAA26429.1.
U00096 Genomic DNA. Translation: AAC73777.1.
AP009048 Genomic DNA. Translation: BAA35331.1.
PIRiS07308.
RefSeqiNP_415209.1. NC_000913.3.
WP_000131702.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FU4X-ray1.80A/B1-83[»]
ProteinModelPortaliP0A9A9.
SMRiP0A9A9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262110. 24 interactors.
849672. 1 interactor.
DIPiDIP-31858N.
IntActiP0A9A9. 50 interactors.
MINTiMINT-1312814.
STRINGi511145.b0683.

2D gel databases

SWISS-2DPAGEP0A9A9.

Proteomic databases

EPDiP0A9A9.
PaxDbiP0A9A9.
PRIDEiP0A9A9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73777; AAC73777; b0683.
BAA35331; BAA35331; BAA35331.
GeneIDi945295.
KEGGiecj:JW0669.
eco:b0683.
PATRICi32116559. VBIEscCol129921_0712.

Organism-specific databases

EchoBASEiEB0354.
EcoGeneiEG10359. fur.

Phylogenomic databases

eggNOGiENOG41090R7. Bacteria.
COG0735. LUCA.
HOGENOMiHOG000014144.
InParanoidiP0A9A9.
KOiK03711.
OMAiDERSDIG.
PhylomeDBiP0A9A9.

Enzyme and pathway databases

BioCyciEcoCyc:PD00260.
ECOL316407:JW0669-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A9A9.
PROiP0A9A9.

Gene expression databases

CollecTFiEXPREG_000007c0.

Family and domain databases

CDDicd07153. Fur_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR002481. FUR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01475. FUR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUR_ECOLI
AccessioniPrimary (citable) accession number: P0A9A9
Secondary accession number(s): P06975
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Activated by cadmium, cobalt, copper, and manganese ions, but not zinc ions.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.