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P0A9A1

- FTNA_SHIFL

UniProt

P0A9A1 - FTNA_SHIFL

Protein

Bacterial non-heme ferritin

Gene

ftnA

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Iron-storage protein.By similarity

    Catalytic activityi

    4 Fe2+ + O2 + 6 H2O = 4 (FeO(OH)) + 8 H+.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi17 – 171Iron 1PROSITE-ProRule annotation
    Metal bindingi49 – 491Iron 3PROSITE-ProRule annotation
    Metal bindingi50 – 501Iron 1PROSITE-ProRule annotation
    Metal bindingi50 – 501Iron 2PROSITE-ProRule annotation
    Metal bindingi53 – 531Iron 1PROSITE-ProRule annotation
    Metal bindingi94 – 941Iron 2PROSITE-ProRule annotation
    Metal bindingi126 – 1261Iron 3PROSITE-ProRule annotation
    Metal bindingi127 – 1271Iron 2PROSITE-ProRule annotation
    Metal bindingi130 – 1301Iron 2PROSITE-ProRule annotation
    Metal bindingi130 – 1301Iron 3PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bacterial non-heme ferritin (EC:1.16.3.2)
    Alternative name(s):
    Ferritin-1
    Gene namesi
    Name:ftnA
    Ordered Locus Names:SF1951, S2044
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 165165Bacterial non-heme ferritinPRO_0000201088Add
    BLAST

    Proteomic databases

    PaxDbiP0A9A1.
    PRIDEiP0A9A1.

    Interactioni

    Subunit structurei

    Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms.By similarity

    Protein-protein interaction databases

    STRINGi198214.SF1951.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A9A1.
    SMRiP0A9A1. Positions 2-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 145145Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family. Prokaryotic subfamily.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1528.
    HOGENOMiHOG000223382.
    KOiK02217.
    OrthoDBiEOG6G4W12.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A9A1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKPEMIEKL NEQMNLELYS SLLYQQMSAW CSYHTFEGAA AFLRRHAQEE    50
    MTHMQRLFDY LTDTGNLPRI NTVESPFAEY SSLDELFQET YKHEQLITQK 100
    INELAHAAMT NQDYPTFNFL QWYVSEQHEE EKLFKSIIDK LSLAGKSGEG 150
    LYFIDKELST LDTQN 165
    Length:165
    Mass (Da):19,424
    Last modified:July 19, 2005 - v1
    Checksum:i5B3AA08BCFE6CDA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN43502.2.
    AE014073 Genomic DNA. Translation: AAP17332.1.
    RefSeqiNP_707795.2. NC_004337.2.
    NP_837523.1. NC_004741.1.

    Genome annotation databases

    EnsemblBacteriaiAAN43502; AAN43502; SF1951.
    AAP17332; AAP17332; S2044.
    GeneIDi1027444.
    1078362.
    KEGGisfl:SF1951.
    sfx:S2044.
    PATRICi18705558. VBIShiFle31049_2270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN43502.2 .
    AE014073 Genomic DNA. Translation: AAP17332.1 .
    RefSeqi NP_707795.2. NC_004337.2.
    NP_837523.1. NC_004741.1.

    3D structure databases

    ProteinModelPortali P0A9A1.
    SMRi P0A9A1. Positions 2-162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.SF1951.

    Proteomic databases

    PaxDbi P0A9A1.
    PRIDEi P0A9A1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN43502 ; AAN43502 ; SF1951 .
    AAP17332 ; AAP17332 ; S2044 .
    GeneIDi 1027444.
    1078362.
    KEGGi sfl:SF1951.
    sfx:S2044.
    PATRICi 18705558. VBIShiFle31049_2270.

    Phylogenomic databases

    eggNOGi COG1528.
    HOGENOMi HOG000223382.
    KOi K02217.
    OrthoDBi EOG6G4W12.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700930 / 2457T / Serotype 2a.

    Entry informationi

    Entry nameiFTNA_SHIFL
    AccessioniPrimary (citable) accession number: P0A9A1
    Secondary accession number(s): P23887
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3