P0A9A1 (FTNA_SHIFL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferritin-1
EC=1.16.3.1

Gene names

Name:	ftnA
Ordered Locus Names:	SF1951, S2044

Organism

Shigella flexneri [Complete proteome] [HAMAP]

Taxonomic identifier

623 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Iron-storage protein By similarity.
Catalytic activity	4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Subunit structure	Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ferritin family. Prokaryotic subfamily. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW iron ion transport Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ferric iron binding Inferred from electronic annotation. Source: InterPro ferroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Ferritin-1		PRO_0000201088
Regions
	Domain	1 – 145	145	Ferritin-like diiron
Sites
	Metal binding	17	1	Iron 1 By similarity
	Metal binding	49	1	Iron 3 By similarity
	Metal binding	50	1	Iron 1 By similarity
	Metal binding	50	1	Iron 2 By similarity
	Metal binding	53	1	Iron 1 By similarity
	Metal binding	94	1	Iron 2 By similarity
	Metal binding	126	1	Iron 3 By similarity
	Metal binding	127	1	Iron 2 By similarity
	Metal binding	130	1	Iron 2 By similarity
	Metal binding	130	1	Iron 3 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A9A1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 5B3AA08BCFE6CDA0	FASTA	165	19,424
	10 20 30 40 50 60 MLKPEMIEKL NEQMNLELYS SLLYQQMSAW CSYHTFEGAA AFLRRHAQEE MTHMQRLFDY 70 80 90 100 110 120 LTDTGNLPRI NTVESPFAEY SSLDELFQET YKHEQLITQK INELAHAAMT NQDYPTFNFL 130 140 150 160 QWYVSEQHEE EKLFKSIIDK LSLAGKSGEG LYFIDKELST LDTQN

References

[1]

"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J. Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a.

[2]

"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T." Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R. Infect. Immun. 71:2775-2786(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700930 / 2457T / Serotype 2a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005674 Genomic DNA. Translation: AAN43502.2. AE014073 Genomic DNA. Translation: AAP17332.1.
RefSeq	NP_707795.2. NC_004337.2. NP_837523.1. NC_004741.1.
3D structure databases
ProteinModelPortal	P0A9A1.
SMR	P0A9A1. Positions 2-162.
ModBase	Search...
Protein-protein interaction databases
STRING	198214.SF1951.
Proteomic databases
PaxDb	P0A9A1.
PRIDE	P0A9A1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN43502; AAN43502; SF1951. AAP17332; AAP17332; S2044.
GeneID	1027444. 1078362.
KEGG	sfl:SF1951. sfx:S2044.
PATRIC	18705558. VBIShiFle31049_2270.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1528.
HOGENOM	HOG000223382.
KO	K02217.
ProtClustDB	PRK10304.
Family and domain databases
Gene3D	1.20.1260.10. 1 hit.
InterPro	IPR001519. Ferritin. IPR009040. Ferritin-like_diiron. IPR009078. Ferritin-like_SF. IPR012347. Ferritin-rel. IPR008331. Ferritin_DPS_dom. [Graphical view]
PANTHER	PTHR11431. PTHR11431. 1 hit.
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTNA_SHIFL

Accession

Primary (citable) accession number: P0A9A1
Secondary accession number(s): P23887

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program