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P0A999

- FTNA_ECOL6

UniProt

P0A999 - FTNA_ECOL6

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Protein
Ferritin-1
Gene
ftnA, c2321
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Iron-storage protein By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Iron 1 By similarity
Metal bindingi49 – 491Iron 3 By similarity
Metal bindingi50 – 501Iron 1 By similarity
Metal bindingi50 – 501Iron 2 By similarity
Metal bindingi53 – 531Iron 1 By similarity
Metal bindingi94 – 941Iron 2 By similarity
Metal bindingi126 – 1261Iron 3 By similarity
Metal bindingi127 – 1271Iron 2 By similarity
Metal bindingi130 – 1301Iron 2 By similarity
Metal bindingi130 – 1301Iron 3 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-1 (EC:1.16.3.1)
Gene namesi
Name:ftnA
Ordered Locus Names:c2321
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Ferritin-1
PRO_0000201087Add
BLAST

Proteomic databases

PRIDEiP0A999.

Interactioni

Subunit structurei

Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms By similarity.

Protein-protein interaction databases

STRINGi199310.c2321.

Structurei

3D structure databases

ProteinModelPortaliP0A999.
SMRiP0A999. Positions 2-162.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 145145Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000223382.
KOiK02217.
OMAiCEDKGFE.
OrthoDBiEOG6G4W12.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A999-1 [UniParc]FASTAAdd to Basket

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MLKPEMIEKL NEQMNLELYS SLLYQQMSAW CSYHTFEGAA AFLRRHAQEE    50
MTHMQRLFDY LTDTGNLPRI NTVESPFAEY SSLDELFQET YKHEQLITQK 100
INELAHAAMT NQDYPTFNFL QWYVSEQHEE EKLFKSIIDK LSLAGKSGEG 150
LYFIDKELST LDTQN 165
Length:165
Mass (Da):19,424
Last modified:July 19, 2005 - v1
Checksum:i5B3AA08BCFE6CDA0
GO

Sequence cautioni

The sequence AAN80780.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80780.1. Different initiation.
RefSeqiNP_754213.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN80780; AAN80780; c2321.
GeneIDi1036934.
KEGGiecc:c2321.
PATRICi18282521. VBIEscCol75197_2177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80780.1 . Different initiation.
RefSeqi NP_754213.1. NC_004431.1.

3D structure databases

ProteinModelPortali P0A999.
SMRi P0A999. Positions 2-162.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 199310.c2321.

Proteomic databases

PRIDEi P0A999.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN80780 ; AAN80780 ; c2321 .
GeneIDi 1036934.
KEGGi ecc:c2321.
PATRICi 18282521. VBIEscCol75197_2177.

Phylogenomic databases

HOGENOMi HOG000223382.
KOi K02217.
OMAi CEDKGFE.
OrthoDBi EOG6G4W12.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.

Entry informationi

Entry nameiFTNA_ECOL6
AccessioniPrimary (citable) accession number: P0A999
Secondary accession number(s): P23887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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