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P0A998 (FTNA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin-1

EC=1.16.3.1
Gene names
Name:ftnA
Synonyms:ftn, gen-165, rsgA
Ordered Locus Names:b1905, JW1893
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Iron-storage protein. Ref.8

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms. Ref.8

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the ferritin family. Prokaryotic subfamily.

Contains 1 ferritin-like diiron domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Ferritin-1
PRO_0000201085

Regions

Domain1 – 145145Ferritin-like diiron

Sites

Metal binding171Iron 1
Metal binding491Iron 3
Metal binding501Iron 1
Metal binding501Iron 2
Metal binding531Iron 1
Metal binding941Iron 2
Metal binding1261Iron 3
Metal binding1271Iron 2
Metal binding1301Iron 2
Metal binding1301Iron 3

Secondary structure

........... 165
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A998 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 5B3AA08BCFE6CDA0

FASTA16519,424
        10         20         30         40         50         60 
MLKPEMIEKL NEQMNLELYS SLLYQQMSAW CSYHTFEGAA AFLRRHAQEE MTHMQRLFDY 

        70         80         90        100        110        120 
LTDTGNLPRI NTVESPFAEY SSLDELFQET YKHEQLITQK INELAHAAMT NQDYPTFNFL 

       130        140        150        160 
QWYVSEQHEE EKLFKSIIDK LSLAGKSGEG LYFIDKELST LDTQN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing of an Escherichia coli K12 gene which encodes a polypeptide having similarity to the human ferritin H subunit."
Izuhara M., Takamune K., Takata R.
Mol. Gen. Genet. 225:510-513(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map."
Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. expand/collapse author list , Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., Horiuchi T.
DNA Res. 3:379-392(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]Robison K., O'Keeffe T., Church G.M.
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 151-165.
Strain: K12 / EMG2.
[6]"Overproduction, purification and characterization of the Escherichia coli ferritin."
Hudson A.J., Andrews S.C., Hawkins C., Williams J.M., Izuhara M., Meldrum F.C., Mann S., Harrison P.M., Guest J.R.
Eur. J. Biochem. 218:985-995(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-20, CHARACTERIZATION.
[7]"How the presence of three iron binding sites affects the iron storage function of the ferritin (EcFtnA) of Escherichia coli."
Treffry A., Zhao Z., Quail M.A., Guest J.R., Harrison P.M.
FEBS Lett. 432:213-218(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[8]"The high-resolution X-ray crystallographic structure of the ferritin (EcFtnA) of Escherichia coli; comparison with human H ferritin (HuHF) and the structures of the Fe(3+) and Zn(2+) derivatives."
Stillman T.J., Hempstead P.D., Artymiuk P.J., Andrews S.C., Hudson A.J., Treffry A., Guest J.R., Harrison P.M.
J. Mol. Biol. 307:587-603(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS), FUNCTION, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53513 Genomic DNA. Translation: CAA37593.1.
U00096 Genomic DNA. Translation: AAC74975.1.
AP009048 Genomic DNA. Translation: BAA15728.1.
U35066 Genomic DNA. Translation: AAA79049.1.
PIRS14069.
RefSeqNP_416418.1. NC_000913.3.
YP_490165.1. NC_007779.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EUMX-ray2.05A/B/C/D/E/F1-165[»]
ProteinModelPortalP0A998.
SMRP0A998. Positions 2-162.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-36198N.
IntActP0A998. 2 interactions.
STRING511145.b1905.

Proteomic databases

PaxDbP0A998.
PRIDEP0A998.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC74975; AAC74975; b1905.
BAA15728; BAA15728; BAA15728.
GeneID12934013.
946410.
KEGGecj:Y75_p1879.
eco:b1905.
PATRIC32119139. VBIEscCol129921_1987.

Organism-specific databases

EchoBASEEB0914.
EcoGeneEG10921. ftnA.

Phylogenomic databases

eggNOGCOG1528.
HOGENOMHOG000223382.
KOK02217.
OMACEDKGFE.
OrthoDBEOG6G4W12.
PhylomeDBP0A998.

Enzyme and pathway databases

BioCycEcoCyc:EG10921-MONOMER.
ECOL316407:JW1893-MONOMER.
MetaCyc:EG10921-MONOMER.

Gene expression databases

GenevestigatorP0A998.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0A998.
PROP0A998.

Entry information

Entry nameFTNA_ECOLI
AccessionPrimary (citable) accession number: P0A998
Secondary accession number(s): P23887
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene