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Protein

Anaerobic glycerol-3-phosphate dehydrogenase subunit C

Gene

glpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Electron transfer protein; may also function as the membrane anchor for the GlpAB dimer.

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Anaerobic glycerol-3-phosphate dehydrogenase subunit B (glpB), Anaerobic glycerol-3-phosphate dehydrogenase subunit A (glpA), Anaerobic glycerol-3-phosphate dehydrogenase subunit C (glpC)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi12Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi15Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi19Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi56Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi59Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi62Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi66Iron-sulfur 1 (4Fe-4S)By similarity1

GO - Molecular functioni

  • 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  • iron-sulfur cluster binding Source: EcoCyc
  • metal ion binding Source: EcoCyc

GO - Biological processi

  • anaerobic respiration Source: EcoCyc
  • electron transport chain Source: EcoCyc
  • glycerol catabolic process Source: UniProtKB-UniPathway

Keywordsi

Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:ANGLYC3PDEHYDROGSUBUNITC-MONOMER
MetaCyc:ANGLYC3PDEHYDROGSUBUNITC-MONOMER
UniPathwayiUPA00618; UER00673

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic glycerol-3-phosphate dehydrogenase subunit C
Short name:
G-3-P dehydrogenase
Gene namesi
Name:glpC
Ordered Locus Names:b2243, JW2237
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10393 glpC

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001592591 – 396Anaerobic glycerol-3-phosphate dehydrogenase subunit CAdd BLAST396

Proteomic databases

PaxDbiP0A996
PRIDEiP0A996

Interactioni

Subunit structurei

Composed of a catalytic GlpA/B dimer and of GlpC.

Protein-protein interaction databases

BioGridi4262942, 101 interactors
DIPiDIP-35835N
IntActiP0A996, 20 interactors
STRINGi316385.ECDH10B_2402

Structurei

3D structure databases

ProteinModelPortaliP0A996
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 294Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST28
Domaini45 – 764Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105CHG Bacteria
COG0247 LUCA
HOGENOMiHOG000278500
InParanoidiP0A996
KOiK00113
OMAiCGMPKLE
PhylomeDBiP0A996

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR004017 Cys_rich_dom
IPR017753 G3P_DH_GlpC_su
IPR009051 Helical_ferredxn
PfamiView protein in Pfam
PF02754 CCG, 2 hits
PF13183 Fer4_8, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
TIGRFAMsiTIGR03379 glycerol3P_GlpC, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 2 hits
PS51379 4FE4S_FER_2, 2 hits

Sequencei

Sequence statusi: Complete.

P0A996-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDTSFENCI KCTVCTTACP VSRVNPGYPG PKQAGPDGER LRLKDGALYD
60 70 80 90 100
EALKYCINCK RCEVACPSDV KIGDIIQRAR AKYDTTRPSL RNFVLSHTDL
110 120 130 140 150
MGSVSTPFAP IVNTATSLKP VRQLLDAALK IDHRRTLPKY SFGTFRRWYR
160 170 180 190 200
SVAAQQAQYK DQVAFFHGCF VNYNHPQLGK DLIKVLNAMG TGVQLLSKEK
210 220 230 240 250
CCGVPLIANG FTDKARKQAI TNVESIREAV GVKGIPVIAT SSTCTFALRD
260 270 280 290 300
EYPEVLNVDN KGLRDHIELA TRWLWRKLDE GKTLPLKPLP LKVVYHTPCH
310 320 330 340 350
MEKMGWTLYT LELLRNIPGL ELTVLDSQCC GIAGTYGFKK ENYPTSQAIG
360 370 380 390
APLFRQIEES GADLVVTDCE TCKWQIEMST SLRCEHPITL LAQALA
Length:396
Mass (Da):44,108
Last modified:July 19, 2005 - v1
Checksum:i1DC9203332B6F2F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169C → V in AAA83866 (PubMed:3286606).Curated1
Sequence conflicti206L → V in AAA83866 (PubMed:3286606).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20938 Genomic DNA Translation: AAA83866.1
U00096 Genomic DNA Translation: AAC75303.1
AP009048 Genomic DNA Translation: BAA16062.1
PIRiA64995 DEECNC
RefSeqiNP_416746.1, NC_000913.3
WP_001000379.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75303; AAC75303; b2243
BAA16062; BAA16062; BAA16062
GeneIDi946735
KEGGiecj:JW2237
eco:b2243
PATRICifig|511145.12.peg.2332

Similar proteinsi

Entry informationi

Entry nameiGLPC_ECOLI
AccessioniPrimary (citable) accession number: P0A996
Secondary accession number(s): P13034, P76927, P77679
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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