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Protein

Cold shock-like protein CspE

Gene

cspE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) binding Source: EcoCyc
  • RNA binding Source: EcoliWiki
  • single-stranded DNA binding Source: EcoCyc
  • transcription antitermination factor activity, RNA binding Source: EcoliWiki

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12179-MONOMER.
ECOL316407:JW0618-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock-like protein CspE
Short name:
CSP-E
Gene namesi
Name:cspE
Synonyms:gicA, msmC
Ordered Locus Names:b0623, JW0618
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12179. cspE.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 6968Cold shock-like protein CspEPRO_0000100253Add
BLAST

Proteomic databases

PaxDbiP0A972.
PRIDEiP0A972.

Interactioni

Protein-protein interaction databases

BioGridi4260642. 12 interactions.
DIPiDIP-47834N.
IntActiP0A972. 48 interactions.
MINTiMINT-1221433.
STRINGi511145.b0623.

Structurei

3D structure databases

ProteinModelPortaliP0A972.
SMRiP0A972. Positions 1-69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6661CSDAdd
BLAST

Sequence similaritiesi

Contains 1 CSD (cold-shock) domain.Curated

Phylogenomic databases

eggNOGiCOG1278. LUCA.
HOGENOMiHOG000070674.
InParanoidiP0A972.
KOiK03704.
OMAiHSEIQES.
PhylomeDBiP0A972.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR012156. Cold_shock_CspA.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
PIRSFiPIRSF002599. Cold_shock_A. 1 hit.
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIKGNVKW FNESKGFGFI TPEDGSKDVF VHFSAIQTNG FKTLAEGQRV
60
EFEITNGAKG PSAANVIAL
Length:69
Mass (Da):7,463
Last modified:January 23, 2007 - v2
Checksum:i1C33C920AA82405C
GO

Sequence cautioni

The sequence AAB40823 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581A → R (Ref. 2) Curated

Mass spectrometryi

Molecular mass is 7331 Da from positions 2 - 69. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28497 Genomic DNA. Translation: BAA05856.1.
L29054 Genomic DNA. Translation: AAA67556.1.
S83396 Genomic DNA. Translation: AAN86720.1.
U82598 Genomic DNA. Translation: AAB40823.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73724.1.
AP009048 Genomic DNA. Translation: BAA35266.1.
PIRiS49050.
RefSeqiNP_415156.1. NC_000913.3.
WP_000034825.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73724; AAC73724; b0623.
BAA35266; BAA35266; BAA35266.
GeneIDi23337261.
947024.
KEGGiecj:JW0618.
eco:b0623.
PATRICi32116426. VBIEscCol129921_0653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28497 Genomic DNA. Translation: BAA05856.1.
L29054 Genomic DNA. Translation: AAA67556.1.
S83396 Genomic DNA. Translation: AAN86720.1.
U82598 Genomic DNA. Translation: AAB40823.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73724.1.
AP009048 Genomic DNA. Translation: BAA35266.1.
PIRiS49050.
RefSeqiNP_415156.1. NC_000913.3.
WP_000034825.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A972.
SMRiP0A972. Positions 1-69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260642. 12 interactions.
DIPiDIP-47834N.
IntActiP0A972. 48 interactions.
MINTiMINT-1221433.
STRINGi511145.b0623.

Proteomic databases

PaxDbiP0A972.
PRIDEiP0A972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73724; AAC73724; b0623.
BAA35266; BAA35266; BAA35266.
GeneIDi23337261.
947024.
KEGGiecj:JW0618.
eco:b0623.
PATRICi32116426. VBIEscCol129921_0653.

Organism-specific databases

EchoBASEiEB2096.
EcoGeneiEG12179. cspE.

Phylogenomic databases

eggNOGiCOG1278. LUCA.
HOGENOMiHOG000070674.
InParanoidiP0A972.
KOiK03704.
OMAiHSEIQES.
PhylomeDBiP0A972.

Enzyme and pathway databases

BioCyciEcoCyc:EG12179-MONOMER.
ECOL316407:JW0618-MONOMER.

Miscellaneous databases

PROiP0A972.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR012156. Cold_shock_CspA.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
PIRSFiPIRSF002599. Cold_shock_A. 1 hit.
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSPE_ECOLI
AccessioniPrimary (citable) accession number: P0A972
Secondary accession number(s): P36997, P77103, P80434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.