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Protein

Cold shock-like protein CspD

Gene

cspD

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA replication inhibitor

Keywords - Ligandi

DNA-binding, RNA-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-963-MONOMER.
ECOO157:CSPD-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock-like protein CspD
Short name:
CSP-D
Gene namesi
Name:cspD
Ordered Locus Names:Z1117, ECs0966
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7474Cold shock-like protein CspDPRO_0000100249Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-1219773.
STRINGi155864.Z1117.

Structurei

3D structure databases

ProteinModelPortaliP0A970.
SMRiP0A970. Positions 1-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 6461CSDAdd
BLAST

Sequence similaritiesi

Contains 1 CSD (cold-shock) domain.Curated

Phylogenomic databases

eggNOGiENOG4105VEQ. Bacteria.
COG1278. LUCA.
HOGENOMiHOG000070674.
KOiK03704.
OMAiTSCSHIP.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR012156. Cold_shock_CspA.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012751. CspD.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
PIRSFiPIRSF002599. Cold_shock_A. 1 hit.
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR02381. cspD. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKGTVKWFN NAKGFGFICP EGGGEDIFAH YSTIQMDGYR TLKAGQSVQF
60 70
DVHQGPKGNH ASVIVPVEVE AAVA
Length:74
Mass (Da):7,969
Last modified:July 19, 2005 - v1
Checksum:iC74AB028135BC22C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55262.1.
BA000007 Genomic DNA. Translation: BAB34389.1.
PIRiB85600.
F90749.
RefSeqiNP_308993.1. NC_002695.1.
WP_000410785.1. NZ_LPWC01000318.1.

Genome annotation databases

EnsemblBacteriaiAAG55262; AAG55262; Z1117.
BAB34389; BAB34389; BAB34389.
GeneIDi917710.
KEGGiece:Z1117.
ecs:ECs0966.
PATRICi18350967. VBIEscCol44059_0988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55262.1.
BA000007 Genomic DNA. Translation: BAB34389.1.
PIRiB85600.
F90749.
RefSeqiNP_308993.1. NC_002695.1.
WP_000410785.1. NZ_LPWC01000318.1.

3D structure databases

ProteinModelPortaliP0A970.
SMRiP0A970. Positions 1-64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1219773.
STRINGi155864.Z1117.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG55262; AAG55262; Z1117.
BAB34389; BAB34389; BAB34389.
GeneIDi917710.
KEGGiece:Z1117.
ecs:ECs0966.
PATRICi18350967. VBIEscCol44059_0988.

Phylogenomic databases

eggNOGiENOG4105VEQ. Bacteria.
COG1278. LUCA.
HOGENOMiHOG000070674.
KOiK03704.
OMAiTSCSHIP.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-963-MONOMER.
ECOO157:CSPD-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR012156. Cold_shock_CspA.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012751. CspD.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
PIRSFiPIRSF002599. Cold_shock_A. 1 hit.
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR02381. cspD. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSPD_ECO57
AccessioniPrimary (citable) accession number: P0A970
Secondary accession number(s): P24245
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds single-stranded DNA and RNA, but not double-stranded DNA, through hydrophobic interaction without sequence specificity, resulting in a packed structure.By similarity

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.