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Protein

Cold shock-like protein CspD

Gene

cspD

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity).By similarity

Miscellaneous

Binds single-stranded DNA and RNA, but not double-stranded DNA, through hydrophobic interaction without sequence specificity, resulting in a packed structure.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA replication inhibitor, DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock-like protein CspD
Short name:
CSP-D
Gene namesi
Name:cspD
Ordered Locus Names:Z1117, ECs0966
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001002491 – 74Cold shock-like protein CspDAdd BLAST74

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi155864.Z1117

Structurei

3D structure databases

ProteinModelPortaliP0A970
SMRiP0A970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 64CSDAdd BLAST61

Phylogenomic databases

eggNOGiENOG4105VEQ Bacteria
COG1278 LUCA
HOGENOMiHOG000070674
KOiK03704
OMAiHYSTIKM

Family and domain databases

CDDicd04458 CSP_CDS, 1 hit
InterProiView protein in InterPro
IPR019844 Cold-shock_CS
IPR012156 Cold_shock_CspA
IPR011129 CSD
IPR002059 CSP_DNA-bd
IPR012751 CspD
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF00313 CSD, 1 hit
PIRSFiPIRSF002599 Cold_shock_A, 1 hit
PRINTSiPR00050 COLDSHOCK
SMARTiView protein in SMART
SM00357 CSP, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR02381 cspD, 1 hit
PROSITEiView protein in PROSITE
PS00352 CSD_1, 1 hit
PS51857 CSD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKGTVKWFN NAKGFGFICP EGGGEDIFAH YSTIQMDGYR TLKAGQSVQF
60 70
DVHQGPKGNH ASVIVPVEVE AAVA
Length:74
Mass (Da):7,969
Last modified:July 19, 2005 - v1
Checksum:iC74AB028135BC22C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55262.1
BA000007 Genomic DNA Translation: BAB34389.1
PIRiB85600
F90749
RefSeqiNP_308993.1, NC_002695.1
WP_000410785.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG55262; AAG55262; Z1117
BAB34389; BAB34389; BAB34389
GeneIDi917710
KEGGiece:Z1117
ecs:ECs0966
PATRICifig|386585.9.peg.1082

Similar proteinsi

Entry informationi

Entry nameiCSPD_ECO57
AccessioniPrimary (citable) accession number: P0A970
Secondary accession number(s): P24245
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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