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Protein

Chemotaxis protein CheW

Gene

cheW

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges CheA to the MCPs (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to CheY and CheB (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis protein CheW
Gene namesi
Name:cheW
Ordered Locus Names:SF1936, S2027
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001983481 – 167Chemotaxis protein CheWAdd BLAST167

Proteomic databases

PaxDbiP0A967.

Interactioni

Subunit structurei

An in vitro complex of CheW/CheA(L)/CheA(S) in a 1:1:1 ratio increases the autophosphorylation of CheA and is required for the binding of CheY, the phosphorylation substrate. This complex accounts for 10% of the total number of molecules (By similarity).By similarity

Protein-protein interaction databases

STRINGi198214.SF1936.

Structurei

3D structure databases

ProteinModelPortaliP0A967.
SMRiP0A967.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 156CheW-likePROSITE-ProRule annotationAdd BLAST141

Sequence similaritiesi

Contains 1 cheW-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108V3W. Bacteria.
COG0835. LUCA.
HOGENOMiHOG000254712.
KOiK03408.
OMAiDEEYGVE.

Family and domain databases

InterProiIPR002545. CheW.
[Graphical view]
PfamiPF01584. CheW. 1 hit.
[Graphical view]
SMARTiSM00260. CheW. 1 hit.
[Graphical view]
SUPFAMiSSF50341. SSF50341. 1 hit.
PROSITEiPS50851. CHEW. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGMTNVTKL ASEPSGQEFL VFTLGDEEYG IDILKVQEIR GYDQVTRIAN
60 70 80 90 100
TPAFIKGVTN LRGVIVPIVD LRIKFSQVDV DYNDNTVVIV LNLGQRVVGI
110 120 130 140 150
VVDGVSDVLS LTAEQIRPAP EFAVTLSTEY LTGLGALGDR MLILVNIEKL
160
LNSEEMALLD SAASEVA
Length:167
Mass (Da):18,084
Last modified:April 1, 1988 - v1
Checksum:i9CE642E5F4E91BFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43489.1.
AE014073 Genomic DNA. Translation: AAP17319.1.
RefSeqiNP_707782.1. NC_004337.2.
WP_000147302.1. NZ_LVJC01000107.1.

Genome annotation databases

EnsemblBacteriaiAAN43489; AAN43489; SF1936.
AAP17319; AAP17319; S2027.
GeneIDi1023709.
KEGGisfl:SF1936.
sft:NCTC1_02103.
sfx:S2027.
PATRICi18705520. VBIShiFle31049_2251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43489.1.
AE014073 Genomic DNA. Translation: AAP17319.1.
RefSeqiNP_707782.1. NC_004337.2.
WP_000147302.1. NZ_LVJC01000107.1.

3D structure databases

ProteinModelPortaliP0A967.
SMRiP0A967.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF1936.

Proteomic databases

PaxDbiP0A967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN43489; AAN43489; SF1936.
AAP17319; AAP17319; S2027.
GeneIDi1023709.
KEGGisfl:SF1936.
sft:NCTC1_02103.
sfx:S2027.
PATRICi18705520. VBIShiFle31049_2251.

Phylogenomic databases

eggNOGiENOG4108V3W. Bacteria.
COG0835. LUCA.
HOGENOMiHOG000254712.
KOiK03408.
OMAiDEEYGVE.

Family and domain databases

InterProiIPR002545. CheW.
[Graphical view]
PfamiPF01584. CheW. 1 hit.
[Graphical view]
SMARTiSM00260. CheW. 1 hit.
[Graphical view]
SUPFAMiSSF50341. SSF50341. 1 hit.
PROSITEiPS50851. CHEW. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHEW_SHIFL
AccessioniPrimary (citable) accession number: P0A967
Secondary accession number(s): P07365
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.