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Protein

Chemotaxis protein CheW

Gene

cheW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges CheA to the MCPs (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to CheY and CheB.

GO - Molecular functioni

  • protein domain specific binding Source: CAFA
  • signal transducer activity Source: InterPro

GO - Biological processi

  • chemotaxis Source: EcoCyc
  • establishment of localization in cell Source: CACAO
  • positive regulation of post-translational protein modification Source: CAFA
  • signal transduction Source: EcoCyc

Keywordsi

Biological processChemotaxis

Enzyme and pathway databases

BioCyciEcoCyc:CHEW-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis protein CheW
Gene namesi
Name:cheW
Ordered Locus Names:b1887, JW1876
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10149 cheW

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • methyl accepting chemotaxis protein complex Source: CAFA
  • plasma membrane Source: CAFA

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001983411 – 167Chemotaxis protein CheWAdd BLAST167

Proteomic databases

PaxDbiP0A964
PRIDEiP0A964

Interactioni

Subunit structurei

An in vitro complex of CheW/CheA(L)/CheA(S) in a 1:1:1 ratio increases the autophosphorylation of CheA and is required for the binding of CheY, the phosphorylation substrate. This complex accounts for 10% of the total number of molecules.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
tarP070175EBI-1125947,EBI-1125130

GO - Molecular functioni

  • protein domain specific binding Source: CAFA

Protein-protein interaction databases

BioGridi4261038, 235 interactors
DIPiDIP-48236N
IntActiP0A964, 31 interactors
STRINGi316385.ECDH10B_2028

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 13Combined sources4
Beta strandi17 – 24Combined sources8
Beta strandi27 – 32Combined sources6
Helixi33 – 35Combined sources3
Beta strandi36 – 42Combined sources7
Beta strandi55 – 61Combined sources7
Beta strandi64 – 69Combined sources6
Helixi71 – 75Combined sources5
Beta strandi87 – 93Combined sources7
Beta strandi96 – 111Combined sources16
Turni113 – 115Combined sources3
Beta strandi122 – 125Combined sources4
Helixi128 – 130Combined sources3
Beta strandi133 – 137Combined sources5
Beta strandi140 – 144Combined sources5
Helixi147 – 158Combined sources12
Helixi159 – 161Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HO9NMR-A1-167[»]
ProteinModelPortaliP0A964
SMRiP0A964
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A964

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 156CheW-likePROSITE-ProRule annotationAdd BLAST141

Phylogenomic databases

eggNOGiENOG4108V3W Bacteria
COG0835 LUCA
HOGENOMiHOG000254712
InParanoidiP0A964
KOiK03408
OMAiCVNIMSV
PhylomeDBiP0A964

Family and domain databases

InterProiView protein in InterPro
IPR002545 CheW
IPR036061 CheW-like_dom_sf
PfamiView protein in Pfam
PF01584 CheW, 1 hit
SMARTiView protein in SMART
SM00260 CheW, 1 hit
SUPFAMiSSF50341 SSF50341, 1 hit
PROSITEiView protein in PROSITE
PS50851 CHEW, 1 hit

Sequencei

Sequence statusi: Complete.

P0A964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGMTNVTKL ASEPSGQEFL VFTLGDEEYG IDILKVQEIR GYDQVTRIAN
60 70 80 90 100
TPAFIKGVTN LRGVIVPIVD LRIKFSQVDV DYNDNTVVIV LNLGQRVVGI
110 120 130 140 150
VVDGVSDVLS LTAEQIRPAP EFAVTLSTEY LTGLGALGDR MLILVNIEKL
160
LNSEEMALLD SAASEVA
Length:167
Mass (Da):18,084
Last modified:April 1, 1988 - v1
Checksum:i9CE642E5F4E91BFF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16G → R in AAA23575 (PubMed:2002011).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13462 Genomic DNA Translation: AAA23565.1
U00096 Genomic DNA Translation: AAC74957.1
AP009048 Genomic DNA Translation: BAA15703.1
M34669 Genomic DNA Translation: AAA23575.1
PIRiB25195 QRECCW
RefSeqiNP_416401.1, NC_000913.3
WP_000147302.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74957; AAC74957; b1887
BAA15703; BAA15703; BAA15703
GeneIDi946400
KEGGiecj:JW1876
eco:b1887
PATRICifig|1411691.4.peg.360

Similar proteinsi

Entry informationi

Entry nameiCHEW_ECOLI
AccessioniPrimary (citable) accession number: P0A964
Secondary accession number(s): P07365
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health