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P0A958

- ALKH_SHIFL

UniProt

P0A958 - ALKH_SHIFL

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Protein
KHG/KDPG aldolase
Gene
eda, SF1860, S1926
Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451 By similarity
Active sitei49 – 491 By similarity
Active sitei133 – 1331Schiff-base intermediate with KHG or pyruvate By similarity

GO - Molecular functioni

  1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
  2. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00227.
UPA00856; UER00829.

Names & Taxonomyi

Protein namesi
Recommended name:
KHG/KDPG aldolase
Including the following 2 domains:
4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
Alternative name(s):
2-keto-4-hydroxyglutarate aldolase
Short name:
KHG-aldolase
2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
Alternative name(s):
2-keto-3-deoxy-6-phosphogluconate aldolase
Short name:
KDPG-aldolase
Phospho-2-dehydro-3-deoxygluconate aldolase
Phospho-2-keto-3-deoxygluconate aldolase
Gene namesi
Name:eda
Ordered Locus Names:SF1860, S1926
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213KHG/KDPG aldolase
PRO_0000201042Add
BLAST

Proteomic databases

PaxDbiP0A958.
PRIDEiP0A958.

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

STRINGi198214.SF1860.

Structurei

3D structure databases

ProteinModelPortaliP0A958.
SMRiP0A958. Positions 1-213.

Family & Domainsi

Sequence similaritiesi

Belongs to the KHG/KDPG aldolase family.

Phylogenomic databases

eggNOGiCOG0800.
HOGENOMiHOG000233114.
KOiK01625.
OMAiSWLVPND.
OrthoDBiEOG67DPKT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamiPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01182. eda. 1 hit.
PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A958-1 [UniParc]FASTAAdd to Basket

« Hide

MKNWKTSAES ILTTGPVVPV IVVKKLEHAV PMAKALVAGG VRVLEVTLRT    50
ECAVDAIRAI AKEVPEAIVG AGTVLNPQQL AEVTEAGAQF AISPGLTEPL 100
LKAATEGTIP LIPGISTVSE LMLGMDYGLK EFKFFPAEAN GGVKALQAIA 150
GPFSQVRFCP TGGISPANYR DYLALKSVLC IGGSWLVPAD ALEAGDYDRI 200
TKLAREAVEG AKL 213
Length:213
Mass (Da):22,284
Last modified:July 19, 2005 - v1
Checksum:iCC8D51B50480D0B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN43418.1.
AE014073 Genomic DNA. Translation: AAP17241.1.
RefSeqiNP_707711.1. NC_004337.2.
NP_837432.1. NC_004741.1.

Genome annotation databases

EnsemblBacteriaiAAN43418; AAN43418; SF1860.
AAP17241; AAP17241; S1926.
GeneIDi1025033.
1078259.
KEGGisfl:SF1860.
sfx:S1926.
PATRICi18705292. VBIShiFle31049_2141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN43418.1 .
AE014073 Genomic DNA. Translation: AAP17241.1 .
RefSeqi NP_707711.1. NC_004337.2.
NP_837432.1. NC_004741.1.

3D structure databases

ProteinModelPortali P0A958.
SMRi P0A958. Positions 1-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198214.SF1860.

Proteomic databases

PaxDbi P0A958.
PRIDEi P0A958.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN43418 ; AAN43418 ; SF1860 .
AAP17241 ; AAP17241 ; S1926 .
GeneIDi 1025033.
1078259.
KEGGi sfl:SF1860.
sfx:S1926.
PATRICi 18705292. VBIShiFle31049_2141.

Phylogenomic databases

eggNOGi COG0800.
HOGENOMi HOG000233114.
KOi K01625.
OMAi SWLVPND.
OrthoDBi EOG67DPKT.

Enzyme and pathway databases

UniPathwayi UPA00227 .
UPA00856 ; UER00829 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view ]
Pfami PF01081. Aldolase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01182. eda. 1 hit.
PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiALKH_SHIFL
AccessioniPrimary (citable) accession number: P0A958
Secondary accession number(s): P10177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

It also catalyzes the beta-decarboxylation of oxaloacetate By similarity.

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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