SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0A957

- ALKH_ECO57

UniProt

P0A957 - ALKH_ECO57

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
KHG/KDPG aldolase
Gene
eda, Z2902, ECs2560
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451 By similarity
Active sitei49 – 491 By similarity
Active sitei133 – 1331Schiff-base intermediate with KHG or pyruvate By similarity

GO - Molecular functioni

  1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
  2. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-2534-MONOMER.
    ECOO157:EDA-MONOMER.
    UniPathwayiUPA00227.
    UPA00856; UER00829.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KHG/KDPG aldolase
    Including the following 2 domains:
    4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
    Alternative name(s):
    2-keto-4-hydroxyglutarate aldolase
    Short name:
    KHG-aldolase
    2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
    Alternative name(s):
    2-keto-3-deoxy-6-phosphogluconate aldolase
    Short name:
    KDPG-aldolase
    Phospho-2-dehydro-3-deoxygluconate aldolase
    Phospho-2-keto-3-deoxygluconate aldolase
    Gene namesi
    Name:eda
    Ordered Locus Names:Z2902, ECs2560
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213KHG/KDPG aldolase
    PRO_0000201038Add
    BLAST

    Proteomic databases

    PRIDEiP0A957.

    Interactioni

    Subunit structurei

    Homotrimer By similarity.

    Protein-protein interaction databases

    STRINGi155864.Z2902.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A957.
    SMRiP0A957. Positions 1-213.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KHG/KDPG aldolase family.

    Phylogenomic databases

    eggNOGiCOG0800.
    HOGENOMiHOG000233114.
    KOiK01625.
    OMAiFMIFANS.
    OrthoDBiEOG67DPKT.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR000887. Aldlse_KDPG_KHG.
    IPR013785. Aldolase_TIM.
    [Graphical view]
    PfamiPF01081. Aldolase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01182. eda. 1 hit.
    PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
    PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A957-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNWKTSAES ILTTGPVVPV IVVKKLEHAV PMAKALVAGG VRVLEVTLRT    50
    ECAVDAIRAI AKEVPEAIVG AGTVLNPQQL AEVTEAGAQF AISPGLTEPL 100
    LKAATEGTIP LIPGISTVSE LMLGMDYGLK EFKFFPAEAN GGVKALQAIA 150
    GPFSQVRFCP TGGISPANYR DYLALKSVLC IGGSWLVPAD ALEAGDYDRI 200
    TKLAREAVEG AKL 213
    Length:213
    Mass (Da):22,284
    Last modified:July 19, 2005 - v1
    Checksum:iCC8D51B50480D0B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG56840.1.
    BA000007 Genomic DNA. Translation: BAB35983.1.
    PIRiD85797.
    H90948.
    RefSeqiNP_288287.1. NC_002655.2.
    NP_310587.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG56840; AAG56840; Z2902.
    BAB35983; BAB35983; BAB35983.
    GeneIDi912650.
    961823.
    KEGGiece:Z2902.
    ecs:ECs2560.
    PATRICi18354490. VBIEscCol44059_2456.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG56840.1 .
    BA000007 Genomic DNA. Translation: BAB35983.1 .
    PIRi D85797.
    H90948.
    RefSeqi NP_288287.1. NC_002655.2.
    NP_310587.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali P0A957.
    SMRi P0A957. Positions 1-213.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 155864.Z2902.

    Proteomic databases

    PRIDEi P0A957.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG56840 ; AAG56840 ; Z2902 .
    BAB35983 ; BAB35983 ; BAB35983 .
    GeneIDi 912650.
    961823.
    KEGGi ece:Z2902.
    ecs:ECs2560.
    PATRICi 18354490. VBIEscCol44059_2456.

    Phylogenomic databases

    eggNOGi COG0800.
    HOGENOMi HOG000233114.
    KOi K01625.
    OMAi FMIFANS.
    OrthoDBi EOG67DPKT.

    Enzyme and pathway databases

    UniPathwayi UPA00227 .
    UPA00856 ; UER00829 .
    BioCyci ECOL386585:GJFA-2534-MONOMER.
    ECOO157:EDA-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR000887. Aldlse_KDPG_KHG.
    IPR013785. Aldolase_TIM.
    [Graphical view ]
    Pfami PF01081. Aldolase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01182. eda. 1 hit.
    PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
    PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiALKH_ECO57
    AccessioniPrimary (citable) accession number: P0A957
    Secondary accession number(s): P10177
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: May 14, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    It also catalyzes the beta-decarboxylation of oxaloacetate By similarity.

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi