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P0A917

- OMPX_ECOLI

UniProt

P0A917 - OMPX_ECOLI

Protein

Outer membrane protein X

Gene

ompX

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    BioCyciEcoCyc:EG12117-MONOMER.
    ECOL316407:JW0799-MONOMER.

    Protein family/group databases

    TCDBi1.B.6.2.1. the ompa-ompf porin (oop) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Outer membrane protein X
    Gene namesi
    Name:ompX
    Synonyms:ybiG
    Ordered Locus Names:b0814, JW0799
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG12135. ompX.

    Subcellular locationi

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell outer membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 171148Outer membrane protein XPRO_0000020199Add
    BLAST

    Proteomic databases

    PaxDbiP0A917.
    PRIDEiP0A917.

    2D gel databases

    SWISS-2DPAGEP0A917.

    Expressioni

    Gene expression databases

    GenevestigatoriP0A917.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-48016N.
    IntActiP0A917. 2 interactions.
    MINTiMINT-1256834.
    STRINGi511145.b0814.

    Structurei

    Secondary structure

    1
    171
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi25 – 3713
    Turni38 – 403
    Beta strandi41 – 5414
    Beta strandi55 – 573
    Beta strandi59 – 7416
    Beta strandi75 – 773
    Beta strandi80 – 9718
    Beta strandi100 – 11718
    Turni118 – 1203
    Beta strandi121 – 13818
    Beta strandi141 – 1433
    Beta strandi144 – 15512
    Beta strandi158 – 17013

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ORMNMR-A24-171[»]
    1Q9FNMR-A24-171[»]
    1Q9GNMR-A24-171[»]
    1QJ8X-ray1.90A24-171[»]
    1QJ9X-ray2.10A24-171[»]
    2M06NMR-A24-171[»]
    2M07NMR-A24-171[»]
    ProteinModelPortaliP0A917.
    SMRiP0A917. Positions 24-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0A917.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 252Periplasmic
    Topological domaini36 – 449Extracellular
    Topological domaini55 – 595Periplasmic
    Topological domaini70 – 8516ExtracellularAdd
    BLAST
    Topological domaini96 – 994Periplasmic
    Topological domaini110 – 12920ExtracellularAdd
    BLAST
    Topological domaini140 – 1434Periplasmic
    Topological domaini154 – 1607Extracellular
    Topological domaini171 – 1711Periplasmic

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 3510Beta stranded
    Transmembranei45 – 5410Beta stranded
    Transmembranei60 – 6910Beta stranded
    Transmembranei86 – 9510Beta stranded
    Transmembranei100 – 10910Beta stranded
    Transmembranei130 – 13910Beta stranded
    Transmembranei144 – 15310Beta stranded
    Transmembranei161 – 17010Beta stranded

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Ail/OmpX/PagC/Lom family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane beta strand

    Phylogenomic databases

    eggNOGiCOG3637.
    HOGENOMiHOG000118160.
    KOiK11934.
    OMAiNGFNLKY.
    OrthoDBiEOG63VC0N.

    Family and domain databases

    Gene3Di2.40.160.20. 1 hit.
    InterProiIPR000758. Enterovir_OMP.
    IPR017690. OM_insertion_C_omp85_target.
    IPR011250. OMP/PagP_b-brl.
    IPR027385. OMP_b-brl.
    [Graphical view]
    PfamiPF13505. OMP_b-brl. 1 hit.
    [Graphical view]
    PRINTSiPR00316. ENTEROVIROMP.
    SUPFAMiSSF56925. SSF56925. 1 hit.
    TIGRFAMsiTIGR03304. OMP85_target. 1 hit.
    PROSITEiPS00694. ENT_VIR_OMP_1. 1 hit.
    PS00695. ENT_VIR_OMP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0A917-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIACLSAL AAVLAFTAGT SVAATSTVTG GYAQSDAQGQ MNKMGGFNLK    50
    YRYEEDNSPL GVIGSFTYTE KSRTASSGDY NKNQYYGITA GPAYRINDWA 100
    SIYGVVGVGY GKFQTTEYPT YKHDTSDYGF SYGAGLQFNP MENVALDFSY 150
    EQSRIRSVDV GTWIAGVGYR F 171
    Length:171
    Mass (Da):18,603
    Last modified:July 19, 2005 - v1
    Checksum:i77CE1245DAE81462
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 101L → M in AAA21856. (PubMed:8021175)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37088 Genomic DNA. Translation: AAA66329.1.
    U00096 Genomic DNA. Translation: AAC73901.1.
    AP009048 Genomic DNA. Translation: BAA35486.1.
    U04242 Genomic DNA. Translation: AAA21856.1.
    PIRiI55173.
    RefSeqiNP_415335.1. NC_000913.3.
    YP_489087.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73901; AAC73901; b0814.
    BAA35486; BAA35486; BAA35486.
    GeneIDi12932016.
    944967.
    KEGGiecj:Y75_p0787.
    eco:b0814.
    PATRICi32116831. VBIEscCol129921_0841.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37088 Genomic DNA. Translation: AAA66329.1 .
    U00096 Genomic DNA. Translation: AAC73901.1 .
    AP009048 Genomic DNA. Translation: BAA35486.1 .
    U04242 Genomic DNA. Translation: AAA21856.1 .
    PIRi I55173.
    RefSeqi NP_415335.1. NC_000913.3.
    YP_489087.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ORM NMR - A 24-171 [» ]
    1Q9F NMR - A 24-171 [» ]
    1Q9G NMR - A 24-171 [» ]
    1QJ8 X-ray 1.90 A 24-171 [» ]
    1QJ9 X-ray 2.10 A 24-171 [» ]
    2M06 NMR - A 24-171 [» ]
    2M07 NMR - A 24-171 [» ]
    ProteinModelPortali P0A917.
    SMRi P0A917. Positions 24-171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-48016N.
    IntActi P0A917. 2 interactions.
    MINTi MINT-1256834.
    STRINGi 511145.b0814.

    Protein family/group databases

    TCDBi 1.B.6.2.1. the ompa-ompf porin (oop) family.

    2D gel databases

    SWISS-2DPAGE P0A917.

    Proteomic databases

    PaxDbi P0A917.
    PRIDEi P0A917.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73901 ; AAC73901 ; b0814 .
    BAA35486 ; BAA35486 ; BAA35486 .
    GeneIDi 12932016.
    944967.
    KEGGi ecj:Y75_p0787.
    eco:b0814.
    PATRICi 32116831. VBIEscCol129921_0841.

    Organism-specific databases

    EchoBASEi EB2056.
    EcoGenei EG12135. ompX.

    Phylogenomic databases

    eggNOGi COG3637.
    HOGENOMi HOG000118160.
    KOi K11934.
    OMAi NGFNLKY.
    OrthoDBi EOG63VC0N.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG12117-MONOMER.
    ECOL316407:JW0799-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P0A917.
    PROi P0A917.

    Gene expression databases

    Genevestigatori P0A917.

    Family and domain databases

    Gene3Di 2.40.160.20. 1 hit.
    InterProi IPR000758. Enterovir_OMP.
    IPR017690. OM_insertion_C_omp85_target.
    IPR011250. OMP/PagP_b-brl.
    IPR027385. OMP_b-brl.
    [Graphical view ]
    Pfami PF13505. OMP_b-brl. 1 hit.
    [Graphical view ]
    PRINTSi PR00316. ENTEROVIROMP.
    SUPFAMi SSF56925. SSF56925. 1 hit.
    TIGRFAMsi TIGR03304. OMP85_target. 1 hit.
    PROSITEi PS00694. ENT_VIR_OMP_1. 1 hit.
    PS00695. ENT_VIR_OMP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of an outer membrane protein, OmpX, in Escherichia coli that is homologous to a family of outer membrane proteins including Ail of Yersinia enterocolitica."
      Mecsas J., Welch R., Erickson J.W., Gross C.A.
      J. Bacteriol. 177:799-804(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "Characterization of the sigma 38-dependent expression of a core Escherichia coli starvation gene, pexB."
      Lomovskaya O.L., Kidwell J.P., Matin A.
      J. Bacteriol. 176:3928-3935(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-137.
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    6. "Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis."
      Molloy M.P., Herbert B.R., Walsh B.J., Tyler M.I., Traini M., Sanchez J.-C., Hochstrasser D.F., Williams K.L., Gooley A.A.
      Electrophoresis 19:837-844(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-28.
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    7. "The structure of the outer membrane protein OmpX from Escherichia coli reveals possible mechanisms of virulence."
      Vogt J., Schulz G.E.
      Structure 7:1301-1309(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 24-171.

    Entry informationi

    Entry nameiOMPX_ECOLI
    AccessioniPrimary (citable) accession number: P0A917
    Secondary accession number(s): P36546
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3