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P0A917

- OMPX_ECOLI

UniProt

P0A917 - OMPX_ECOLI

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Protein

Outer membrane protein X

Gene
ompX, ybiG, b0814, JW0799
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:EG12117-MONOMER.
ECOL316407:JW0799-MONOMER.

Protein family/group databases

TCDBi1.B.6.2.1. the ompa-ompf porin (oop) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein X
Gene namesi
Name:ompX
Synonyms:ybiG
Ordered Locus Names:b0814, JW0799
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG12135. ompX.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 252Periplasmic
Transmembranei26 – 3510Beta stranded
Topological domaini36 – 449Extracellular
Transmembranei45 – 5410Beta stranded
Topological domaini55 – 595Periplasmic
Transmembranei60 – 6910Beta stranded
Topological domaini70 – 8516ExtracellularAdd
BLAST
Transmembranei86 – 9510Beta stranded
Topological domaini96 – 994Periplasmic
Transmembranei100 – 10910Beta stranded
Topological domaini110 – 12920ExtracellularAdd
BLAST
Transmembranei130 – 13910Beta stranded
Topological domaini140 – 1434Periplasmic
Transmembranei144 – 15310Beta stranded
Topological domaini154 – 1607Extracellular
Transmembranei161 – 17010Beta stranded
Topological domaini171 – 1711Periplasmic

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 171148Outer membrane protein XPRO_0000020199Add
BLAST

Proteomic databases

PaxDbiP0A917.
PRIDEiP0A917.

2D gel databases

SWISS-2DPAGEP0A917.

Expressioni

Gene expression databases

GenevestigatoriP0A917.

Interactioni

Protein-protein interaction databases

DIPiDIP-48016N.
IntActiP0A917. 2 interactions.
MINTiMINT-1256834.
STRINGi511145.b0814.

Structurei

Secondary structure

1
171
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 3713
Turni38 – 403
Beta strandi41 – 5414
Beta strandi55 – 573
Beta strandi59 – 7416
Beta strandi75 – 773
Beta strandi80 – 9718
Beta strandi100 – 11718
Turni118 – 1203
Beta strandi121 – 13818
Beta strandi141 – 1433
Beta strandi144 – 15512
Beta strandi158 – 17013

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ORMNMR-A24-171[»]
1Q9FNMR-A24-171[»]
1Q9GNMR-A24-171[»]
1QJ8X-ray1.90A24-171[»]
1QJ9X-ray2.10A24-171[»]
2M06NMR-A24-171[»]
2M07NMR-A24-171[»]
ProteinModelPortaliP0A917.
SMRiP0A917. Positions 24-171.

Miscellaneous databases

EvolutionaryTraceiP0A917.

Family & Domainsi

Sequence similaritiesi

Belongs to the Ail/OmpX/PagC/Lom family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiCOG3637.
HOGENOMiHOG000118160.
KOiK11934.
OMAiNGFNLKY.
OrthoDBiEOG63VC0N.

Family and domain databases

Gene3Di2.40.160.20. 1 hit.
InterProiIPR000758. Enterovir_OMP.
IPR017690. OM_insertion_C_omp85_target.
IPR011250. OMP/PagP_b-brl.
IPR027385. OMP_b-brl.
[Graphical view]
PfamiPF13505. OMP_b-brl. 1 hit.
[Graphical view]
PRINTSiPR00316. ENTEROVIROMP.
SUPFAMiSSF56925. SSF56925. 1 hit.
TIGRFAMsiTIGR03304. OMP85_target. 1 hit.
PROSITEiPS00694. ENT_VIR_OMP_1. 1 hit.
PS00695. ENT_VIR_OMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A917-1 [UniParc]FASTAAdd to Basket

« Hide

MKKIACLSAL AAVLAFTAGT SVAATSTVTG GYAQSDAQGQ MNKMGGFNLK    50
YRYEEDNSPL GVIGSFTYTE KSRTASSGDY NKNQYYGITA GPAYRINDWA 100
SIYGVVGVGY GKFQTTEYPT YKHDTSDYGF SYGAGLQFNP MENVALDFSY 150
EQSRIRSVDV GTWIAGVGYR F 171
Length:171
Mass (Da):18,603
Last modified:July 19, 2005 - v1
Checksum:i77CE1245DAE81462
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101L → M in AAA21856. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37088 Genomic DNA. Translation: AAA66329.1.
U00096 Genomic DNA. Translation: AAC73901.1.
AP009048 Genomic DNA. Translation: BAA35486.1.
U04242 Genomic DNA. Translation: AAA21856.1.
PIRiI55173.
RefSeqiNP_415335.1. NC_000913.3.
YP_489087.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73901; AAC73901; b0814.
BAA35486; BAA35486; BAA35486.
GeneIDi12932016.
944967.
KEGGiecj:Y75_p0787.
eco:b0814.
PATRICi32116831. VBIEscCol129921_0841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37088 Genomic DNA. Translation: AAA66329.1 .
U00096 Genomic DNA. Translation: AAC73901.1 .
AP009048 Genomic DNA. Translation: BAA35486.1 .
U04242 Genomic DNA. Translation: AAA21856.1 .
PIRi I55173.
RefSeqi NP_415335.1. NC_000913.3.
YP_489087.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ORM NMR - A 24-171 [» ]
1Q9F NMR - A 24-171 [» ]
1Q9G NMR - A 24-171 [» ]
1QJ8 X-ray 1.90 A 24-171 [» ]
1QJ9 X-ray 2.10 A 24-171 [» ]
2M06 NMR - A 24-171 [» ]
2M07 NMR - A 24-171 [» ]
ProteinModelPortali P0A917.
SMRi P0A917. Positions 24-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-48016N.
IntActi P0A917. 2 interactions.
MINTi MINT-1256834.
STRINGi 511145.b0814.

Protein family/group databases

TCDBi 1.B.6.2.1. the ompa-ompf porin (oop) family.

2D gel databases

SWISS-2DPAGE P0A917.

Proteomic databases

PaxDbi P0A917.
PRIDEi P0A917.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73901 ; AAC73901 ; b0814 .
BAA35486 ; BAA35486 ; BAA35486 .
GeneIDi 12932016.
944967.
KEGGi ecj:Y75_p0787.
eco:b0814.
PATRICi 32116831. VBIEscCol129921_0841.

Organism-specific databases

EchoBASEi EB2056.
EcoGenei EG12135. ompX.

Phylogenomic databases

eggNOGi COG3637.
HOGENOMi HOG000118160.
KOi K11934.
OMAi NGFNLKY.
OrthoDBi EOG63VC0N.

Enzyme and pathway databases

BioCyci EcoCyc:EG12117-MONOMER.
ECOL316407:JW0799-MONOMER.

Miscellaneous databases

EvolutionaryTracei P0A917.
PROi P0A917.

Gene expression databases

Genevestigatori P0A917.

Family and domain databases

Gene3Di 2.40.160.20. 1 hit.
InterProi IPR000758. Enterovir_OMP.
IPR017690. OM_insertion_C_omp85_target.
IPR011250. OMP/PagP_b-brl.
IPR027385. OMP_b-brl.
[Graphical view ]
Pfami PF13505. OMP_b-brl. 1 hit.
[Graphical view ]
PRINTSi PR00316. ENTEROVIROMP.
SUPFAMi SSF56925. SSF56925. 1 hit.
TIGRFAMsi TIGR03304. OMP85_target. 1 hit.
PROSITEi PS00694. ENT_VIR_OMP_1. 1 hit.
PS00695. ENT_VIR_OMP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of an outer membrane protein, OmpX, in Escherichia coli that is homologous to a family of outer membrane proteins including Ail of Yersinia enterocolitica."
    Mecsas J., Welch R., Erickson J.W., Gross C.A.
    J. Bacteriol. 177:799-804(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Characterization of the sigma 38-dependent expression of a core Escherichia coli starvation gene, pexB."
    Lomovskaya O.L., Kidwell J.P., Matin A.
    J. Bacteriol. 176:3928-3935(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-137.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis."
    Molloy M.P., Herbert B.R., Walsh B.J., Tyler M.I., Traini M., Sanchez J.-C., Hochstrasser D.F., Williams K.L., Gooley A.A.
    Electrophoresis 19:837-844(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-28.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  7. "The structure of the outer membrane protein OmpX from Escherichia coli reveals possible mechanisms of virulence."
    Vogt J., Schulz G.E.
    Structure 7:1301-1309(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 24-171.

Entry informationi

Entry nameiOMPX_ECOLI
AccessioniPrimary (citable) accession number: P0A917
Secondary accession number(s): P36546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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