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P0A917

- OMPX_ECOLI

UniProt

P0A917 - OMPX_ECOLI

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Protein

Outer membrane protein X

Gene

ompX

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:EG12117-MONOMER.
ECOL316407:JW0799-MONOMER.

Protein family/group databases

TCDBi1.B.6.2.1. the ompa-ompf porin (oop) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein X
Gene namesi
Name:ompX
Synonyms:ybiG
Ordered Locus Names:b0814, JW0799
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG12135. ompX.

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 171148Outer membrane protein XPRO_0000020199Add
BLAST

Proteomic databases

PaxDbiP0A917.
PRIDEiP0A917.

2D gel databases

SWISS-2DPAGEP0A917.

Expressioni

Gene expression databases

GenevestigatoriP0A917.

Interactioni

Protein-protein interaction databases

DIPiDIP-48016N.
IntActiP0A917. 2 interactions.
MINTiMINT-1256834.
STRINGi511145.b0814.

Structurei

Secondary structure

1
171
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 3713
Turni38 – 403
Beta strandi41 – 5414
Beta strandi55 – 573
Beta strandi59 – 7416
Beta strandi75 – 773
Beta strandi80 – 9718
Beta strandi100 – 11718
Turni118 – 1203
Beta strandi121 – 13818
Beta strandi141 – 1433
Beta strandi144 – 15512
Beta strandi158 – 17013

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ORMNMR-A24-171[»]
1Q9FNMR-A24-171[»]
1Q9GNMR-A24-171[»]
1QJ8X-ray1.90A24-171[»]
1QJ9X-ray2.10A24-171[»]
2M06NMR-A24-171[»]
2M07NMR-A24-171[»]
ProteinModelPortaliP0A917.
SMRiP0A917. Positions 24-171.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A917.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 252Periplasmic
Topological domaini36 – 449Extracellular
Topological domaini55 – 595Periplasmic
Topological domaini70 – 8516ExtracellularAdd
BLAST
Topological domaini96 – 994Periplasmic
Topological domaini110 – 12920ExtracellularAdd
BLAST
Topological domaini140 – 1434Periplasmic
Topological domaini154 – 1607Extracellular
Topological domaini171 – 1711Periplasmic

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 3510Beta stranded
Transmembranei45 – 5410Beta stranded
Transmembranei60 – 6910Beta stranded
Transmembranei86 – 9510Beta stranded
Transmembranei100 – 10910Beta stranded
Transmembranei130 – 13910Beta stranded
Transmembranei144 – 15310Beta stranded
Transmembranei161 – 17010Beta stranded

Family & Domainsi

Sequence similaritiesi

Belongs to the Ail/OmpX/PagC/Lom family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiCOG3637.
HOGENOMiHOG000118160.
KOiK11934.
OMAiNGFNLKY.
OrthoDBiEOG63VC0N.

Family and domain databases

Gene3Di2.40.160.20. 1 hit.
InterProiIPR000758. Enterovir_OMP.
IPR017690. OM_insertion_C_omp85_target.
IPR011250. OMP/PagP_b-brl.
IPR027385. OMP_b-brl.
[Graphical view]
PfamiPF13505. OMP_b-brl. 1 hit.
[Graphical view]
PRINTSiPR00316. ENTEROVIROMP.
SUPFAMiSSF56925. SSF56925. 1 hit.
TIGRFAMsiTIGR03304. OMP85_target. 1 hit.
PROSITEiPS00694. ENT_VIR_OMP_1. 1 hit.
PS00695. ENT_VIR_OMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A917-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKIACLSAL AAVLAFTAGT SVAATSTVTG GYAQSDAQGQ MNKMGGFNLK
60 70 80 90 100
YRYEEDNSPL GVIGSFTYTE KSRTASSGDY NKNQYYGITA GPAYRINDWA
110 120 130 140 150
SIYGVVGVGY GKFQTTEYPT YKHDTSDYGF SYGAGLQFNP MENVALDFSY
160 170
EQSRIRSVDV GTWIAGVGYR F
Length:171
Mass (Da):18,603
Last modified:July 19, 2005 - v1
Checksum:i77CE1245DAE81462
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101L → M in AAA21856. (PubMed:8021175)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37088 Genomic DNA. Translation: AAA66329.1.
U00096 Genomic DNA. Translation: AAC73901.1.
AP009048 Genomic DNA. Translation: BAA35486.1.
U04242 Genomic DNA. Translation: AAA21856.1.
PIRiI55173.
RefSeqiNP_415335.1. NC_000913.3.
YP_489087.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73901; AAC73901; b0814.
BAA35486; BAA35486; BAA35486.
GeneIDi12932016.
944967.
KEGGiecj:Y75_p0787.
eco:b0814.
PATRICi32116831. VBIEscCol129921_0841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37088 Genomic DNA. Translation: AAA66329.1 .
U00096 Genomic DNA. Translation: AAC73901.1 .
AP009048 Genomic DNA. Translation: BAA35486.1 .
U04242 Genomic DNA. Translation: AAA21856.1 .
PIRi I55173.
RefSeqi NP_415335.1. NC_000913.3.
YP_489087.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ORM NMR - A 24-171 [» ]
1Q9F NMR - A 24-171 [» ]
1Q9G NMR - A 24-171 [» ]
1QJ8 X-ray 1.90 A 24-171 [» ]
1QJ9 X-ray 2.10 A 24-171 [» ]
2M06 NMR - A 24-171 [» ]
2M07 NMR - A 24-171 [» ]
ProteinModelPortali P0A917.
SMRi P0A917. Positions 24-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-48016N.
IntActi P0A917. 2 interactions.
MINTi MINT-1256834.
STRINGi 511145.b0814.

Protein family/group databases

TCDBi 1.B.6.2.1. the ompa-ompf porin (oop) family.

2D gel databases

SWISS-2DPAGE P0A917.

Proteomic databases

PaxDbi P0A917.
PRIDEi P0A917.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73901 ; AAC73901 ; b0814 .
BAA35486 ; BAA35486 ; BAA35486 .
GeneIDi 12932016.
944967.
KEGGi ecj:Y75_p0787.
eco:b0814.
PATRICi 32116831. VBIEscCol129921_0841.

Organism-specific databases

EchoBASEi EB2056.
EcoGenei EG12135. ompX.

Phylogenomic databases

eggNOGi COG3637.
HOGENOMi HOG000118160.
KOi K11934.
OMAi NGFNLKY.
OrthoDBi EOG63VC0N.

Enzyme and pathway databases

BioCyci EcoCyc:EG12117-MONOMER.
ECOL316407:JW0799-MONOMER.

Miscellaneous databases

EvolutionaryTracei P0A917.
PROi P0A917.

Gene expression databases

Genevestigatori P0A917.

Family and domain databases

Gene3Di 2.40.160.20. 1 hit.
InterProi IPR000758. Enterovir_OMP.
IPR017690. OM_insertion_C_omp85_target.
IPR011250. OMP/PagP_b-brl.
IPR027385. OMP_b-brl.
[Graphical view ]
Pfami PF13505. OMP_b-brl. 1 hit.
[Graphical view ]
PRINTSi PR00316. ENTEROVIROMP.
SUPFAMi SSF56925. SSF56925. 1 hit.
TIGRFAMsi TIGR03304. OMP85_target. 1 hit.
PROSITEi PS00694. ENT_VIR_OMP_1. 1 hit.
PS00695. ENT_VIR_OMP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of an outer membrane protein, OmpX, in Escherichia coli that is homologous to a family of outer membrane proteins including Ail of Yersinia enterocolitica."
    Mecsas J., Welch R., Erickson J.W., Gross C.A.
    J. Bacteriol. 177:799-804(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Characterization of the sigma 38-dependent expression of a core Escherichia coli starvation gene, pexB."
    Lomovskaya O.L., Kidwell J.P., Matin A.
    J. Bacteriol. 176:3928-3935(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-137.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis."
    Molloy M.P., Herbert B.R., Walsh B.J., Tyler M.I., Traini M., Sanchez J.-C., Hochstrasser D.F., Williams K.L., Gooley A.A.
    Electrophoresis 19:837-844(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-28.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  7. "The structure of the outer membrane protein OmpX from Escherichia coli reveals possible mechanisms of virulence."
    Vogt J., Schulz G.E.
    Structure 7:1301-1309(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 24-171.

Entry informationi

Entry nameiOMPX_ECOLI
AccessioniPrimary (citable) accession number: P0A917
Secondary accession number(s): P36546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3