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P0A917 (OMPX_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Outer membrane protein X
Gene names
Name:ompX
Synonyms:ybiG
Ordered Locus Names:b0814, JW0799
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell outer membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the Ail/OmpX/PagC/Lom family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.6
Chain24 – 171148Outer membrane protein X
PRO_0000020199

Regions

Topological domain24 – 252Periplasmic
Transmembrane26 – 3510Beta stranded
Topological domain36 – 449Extracellular
Transmembrane45 – 5410Beta stranded
Topological domain55 – 595Periplasmic
Transmembrane60 – 6910Beta stranded
Topological domain70 – 8516Extracellular
Transmembrane86 – 9510Beta stranded
Topological domain96 – 994Periplasmic
Transmembrane100 – 10910Beta stranded
Topological domain110 – 12920Extracellular
Transmembrane130 – 13910Beta stranded
Topological domain140 – 1434Periplasmic
Transmembrane144 – 15310Beta stranded
Topological domain154 – 1607Extracellular
Transmembrane161 – 17010Beta stranded
Topological domain1711Periplasmic

Experimental info

Sequence conflict101L → M in AAA21856. Ref.5

Secondary structure

.................... 171
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A917 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 77CE1245DAE81462

FASTA17118,603
        10         20         30         40         50         60 
MKKIACLSAL AAVLAFTAGT SVAATSTVTG GYAQSDAQGQ MNKMGGFNLK YRYEEDNSPL 

        70         80         90        100        110        120 
GVIGSFTYTE KSRTASSGDY NKNQYYGITA GPAYRINDWA SIYGVVGVGY GKFQTTEYPT 

       130        140        150        160        170 
YKHDTSDYGF SYGAGLQFNP MENVALDFSY EQSRIRSVDV GTWIAGVGYR F 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of an outer membrane protein, OmpX, in Escherichia coli that is homologous to a family of outer membrane proteins including Ail of Yersinia enterocolitica."
Mecsas J., Welch R., Erickson J.W., Gross C.A.
J. Bacteriol. 177:799-804(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[2]"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map."
Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. expand/collapse author list , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T.
DNA Res. 3:137-155(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Characterization of the sigma 38-dependent expression of a core Escherichia coli starvation gene, pexB."
Lomovskaya O.L., Kidwell J.P., Matin A.
J. Bacteriol. 176:3928-3935(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-137.
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]"Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis."
Molloy M.P., Herbert B.R., Walsh B.J., Tyler M.I., Traini M., Sanchez J.-C., Hochstrasser D.F., Williams K.L., Gooley A.A.
Electrophoresis 19:837-844(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-28.
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[7]"The structure of the outer membrane protein OmpX from Escherichia coli reveals possible mechanisms of virulence."
Vogt J., Schulz G.E.
Structure 7:1301-1309(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 24-171.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L37088 Genomic DNA. Translation: AAA66329.1.
U00096 Genomic DNA. Translation: AAC73901.1.
AP009048 Genomic DNA. Translation: BAA35486.1.
U04242 Genomic DNA. Translation: AAA21856.1.
PIRI55173.
RefSeqNP_415335.1. NC_000913.3.
YP_489087.1. NC_007779.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ORMNMR-A24-171[»]
1Q9FNMR-A24-171[»]
1Q9GNMR-A24-171[»]
1QJ8X-ray1.90A24-171[»]
1QJ9X-ray2.10A24-171[»]
2M06NMR-A24-171[»]
2M07NMR-A24-171[»]
ProteinModelPortalP0A917.
SMRP0A917. Positions 24-171.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-48016N.
IntActP0A917. 2 interactions.
MINTMINT-1256834.
STRING511145.b0814.

Protein family/group databases

TCDB1.B.6.2.1. the ompa-ompf porin (oop) family.

2D gel databases

SWISS-2DPAGEP0A917.

Proteomic databases

PaxDbP0A917.
PRIDEP0A917.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC73901; AAC73901; b0814.
BAA35486; BAA35486; BAA35486.
GeneID12932016.
944967.
KEGGecj:Y75_p0787.
eco:b0814.
PATRIC32116831. VBIEscCol129921_0841.

Organism-specific databases

EchoBASEEB2056.
EcoGeneEG12135. ompX.

Phylogenomic databases

eggNOGCOG3637.
HOGENOMHOG000118160.
KOK11934.
OMANGFNLKY.
OrthoDBEOG63VC0N.

Enzyme and pathway databases

BioCycEcoCyc:EG12117-MONOMER.
ECOL316407:JW0799-MONOMER.

Gene expression databases

GenevestigatorP0A917.

Family and domain databases

Gene3D2.40.160.20. 1 hit.
InterProIPR000758. Enterovir_OMP.
IPR017690. OM_insertion_C_omp85_target.
IPR011250. OMP/PagP_b-brl.
IPR027385. OMP_b-brl.
[Graphical view]
PfamPF13505. OMP_b-brl. 1 hit.
[Graphical view]
PRINTSPR00316. ENTEROVIROMP.
SUPFAMSSF56925. SSF56925. 1 hit.
TIGRFAMsTIGR03304. OMP85_target. 1 hit.
PROSITEPS00694. ENT_VIR_OMP_1. 1 hit.
PS00695. ENT_VIR_OMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0A917.
PROP0A917.

Entry information

Entry nameOMPX_ECOLI
AccessionPrimary (citable) accession number: P0A917
Secondary accession number(s): P36546
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene