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Protein

Outer membrane protein W

Gene

ompW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a receptor for colicin S4.1 Publication

Enzyme and pathway databases

BioCyciEcoCyc:EG11124-MONOMER.
ECOL316407:JW1248-MONOMER.

Protein family/group databases

TCDBi1.B.39.1.6. the bacterial porin, ompw (ompw) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein W
Gene namesi
Name:ompW
Synonyms:yciD
Ordered Locus Names:b1256, JW1248
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11124. ompW.

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 212191Outer membrane protein WPRO_0000020190Add
BLAST

Proteomic databases

PaxDbiP0A915.
PRIDEiP0A915.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
frdBP0AC472EBI-1132929,EBI-906724

Protein-protein interaction databases

BioGridi4263000. 209 interactions.
IntActiP0A915. 5 interactions.
STRINGi511145.b1256.

Structurei

Secondary structure

1
212
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 3711Combined sources
Beta strandi57 – 8024Combined sources
Beta strandi82 – 887Combined sources
Turni89 – 913Combined sources
Beta strandi92 – 1009Combined sources
Beta strandi103 – 1097Combined sources
Beta strandi116 – 13520Combined sources
Helixi137 – 1415Combined sources
Beta strandi144 – 1496Combined sources
Beta strandi152 – 16413Combined sources
Beta strandi166 – 17813Combined sources
Beta strandi181 – 19010Combined sources
Beta strandi195 – 1984Combined sources
Beta strandi202 – 21211Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2F1TX-ray3.00A/B/C22-212[»]
2F1VX-ray2.70A/B/C/D/E/F22-212[»]
ProteinModelPortaliP0A915.
SMRiP0A915. Positions 22-212.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A915.

Family & Domainsi

Sequence similaritiesi

Belongs to the OmpW/AlkL family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105EIF. Bacteria.
COG3047. LUCA.
HOGENOMiHOG000217796.
InParanoidiP0A915.
KOiK07275.
OMAiDYMLTDN.
PhylomeDBiP0A915.

Family and domain databases

Gene3Di2.40.160.20. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR005618. OMPW.
[Graphical view]
PfamiPF03922. OmpW. 1 hit.
[Graphical view]
SUPFAMiSSF56925. SSF56925. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLTVAALA VTTLLSGSAF AHEAGEFFMR AGSATVRPTE GAGGTLGSLG
60 70 80 90 100
GFSVTNNTQL GLTFTYMATD NIGVELLAAT PFRHKIGTRA TGDIATVHHL
110 120 130 140 150
PPTLMAQWYF GDASSKFRPY VGAGINYTTF FDNGFNDHGK EAGLSDLSLK
160 170 180 190 200
DSWGAAGQVG VDYLINRDWL VNMSVWYMDI DTTANYKLGG AQQHDSVRLD
210
PWVFMFSAGY RF
Length:212
Mass (Da):22,928
Last modified:July 19, 2005 - v1
Checksum:iFE6C1208CCF11224
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121T → A in strain: ECOR 52 and ECOR 60.
Natural varianti20 – 201F → Y in strain: ECOR 46 and ECOR 50.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13583 Genomic DNA. Translation: CAA31922.1.
U00096 Genomic DNA. Translation: AAC74338.1.
AP009048 Genomic DNA. Translation: BAA14788.1.
U24195 Genomic DNA. Translation: AAB60065.1.
U24196 Genomic DNA. Translation: AAB60073.1.
U24197 Genomic DNA. Translation: AAB60081.1.
U24198 Genomic DNA. Translation: AAB60089.1.
U24199 Genomic DNA. Translation: AAB60097.1.
U24200 Genomic DNA. Translation: AAB60105.1.
U24201 Genomic DNA. Translation: AAB60113.1.
U24202 Genomic DNA. Translation: AAB60121.1.
U24203 Genomic DNA. Translation: AAB60129.1.
U24204 Genomic DNA. Translation: AAB60137.1.
U24205 Genomic DNA. Translation: AAB60145.1.
U24206 Genomic DNA. Translation: AAB60153.1.
PIRiS07797.
T45501.
RefSeqiNP_415772.1. NC_000913.3.
WP_000737226.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74338; AAC74338; b1256.
BAA14788; BAA14788; BAA14788.
GeneIDi945128.
KEGGiecj:JW1248.
eco:b1256.
PATRICi32117772. VBIEscCol129921_1306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13583 Genomic DNA. Translation: CAA31922.1.
U00096 Genomic DNA. Translation: AAC74338.1.
AP009048 Genomic DNA. Translation: BAA14788.1.
U24195 Genomic DNA. Translation: AAB60065.1.
U24196 Genomic DNA. Translation: AAB60073.1.
U24197 Genomic DNA. Translation: AAB60081.1.
U24198 Genomic DNA. Translation: AAB60089.1.
U24199 Genomic DNA. Translation: AAB60097.1.
U24200 Genomic DNA. Translation: AAB60105.1.
U24201 Genomic DNA. Translation: AAB60113.1.
U24202 Genomic DNA. Translation: AAB60121.1.
U24203 Genomic DNA. Translation: AAB60129.1.
U24204 Genomic DNA. Translation: AAB60137.1.
U24205 Genomic DNA. Translation: AAB60145.1.
U24206 Genomic DNA. Translation: AAB60153.1.
PIRiS07797.
T45501.
RefSeqiNP_415772.1. NC_000913.3.
WP_000737226.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2F1TX-ray3.00A/B/C22-212[»]
2F1VX-ray2.70A/B/C/D/E/F22-212[»]
ProteinModelPortaliP0A915.
SMRiP0A915. Positions 22-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263000. 209 interactions.
IntActiP0A915. 5 interactions.
STRINGi511145.b1256.

Protein family/group databases

TCDBi1.B.39.1.6. the bacterial porin, ompw (ompw) family.

Proteomic databases

PaxDbiP0A915.
PRIDEiP0A915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74338; AAC74338; b1256.
BAA14788; BAA14788; BAA14788.
GeneIDi945128.
KEGGiecj:JW1248.
eco:b1256.
PATRICi32117772. VBIEscCol129921_1306.

Organism-specific databases

EchoBASEiEB1114.
EcoGeneiEG11124. ompW.

Phylogenomic databases

eggNOGiENOG4105EIF. Bacteria.
COG3047. LUCA.
HOGENOMiHOG000217796.
InParanoidiP0A915.
KOiK07275.
OMAiDYMLTDN.
PhylomeDBiP0A915.

Enzyme and pathway databases

BioCyciEcoCyc:EG11124-MONOMER.
ECOL316407:JW1248-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A915.
PROiP0A915.

Family and domain databases

Gene3Di2.40.160.20. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR005618. OMPW.
[Graphical view]
PfamiPF03922. OmpW. 1 hit.
[Graphical view]
SUPFAMiSSF56925. SSF56925. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOMPW_ECOLI
AccessioniPrimary (citable) accession number: P0A915
Secondary accession number(s): P21364, P97217, P97220
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.