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Protein

Peptidoglycan-associated lipoprotein

Gene

pal

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Thought to play a role in bacterial envelope integrity. Very strongly associated with the peptidoglycan.

GO - Biological processi

  • cell division Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG10684-MONOMER.
ECOL316407:JW0731-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan-associated lipoprotein
Gene namesi
Name:pal
Synonyms:excC
Ordered Locus Names:b0741, JW0731
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10684. pal.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: EcoCyc
  • cell outer membrane Source: EcoCyc
  • integral component of membrane Source: InterPro
  • intrinsic component of periplasmic side of cell outer membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000002012022 – 173Peptidoglycan-associated lipoproteinAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi22N-palmitoyl cysteinePROSITE-ProRule annotation1 Publication1
Lipidationi22S-diacylglycerol cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiP0A912.
PaxDbiP0A912.
PRIDEiP0A912.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
lolEP759582EBI-1124760,EBI-1125190
tolBP0A8554EBI-1124760,EBI-7180728

Protein-protein interaction databases

BioGridi4260724. 230 interactors.
DIPiDIP-51001N.
IntActiP0A912. 8 interactors.
MINTiMINT-7259928.
STRINGi511145.b0741.

Structurei

Secondary structure

1173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi69 – 72Combined sources4
Helixi82 – 84Combined sources3
Helixi85 – 97Combined sources13
Beta strandi103 – 107Combined sources5
Beta strandi111 – 113Combined sources3
Helixi115 – 135Combined sources21
Helixi140 – 142Combined sources3
Beta strandi143 – 147Combined sources5
Helixi160 – 166Combined sources7
Beta strandi167 – 172Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OAPX-ray1.93A65-173[»]
2HQSX-ray1.50C/E/G/H65-173[»]
2W8BX-ray1.86C/E/G/H65-173[»]
ProteinModelPortaliP0A912.
SMRiP0A912.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A912.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 173OmpA-likePROSITE-ProRule annotationAdd BLAST114

Sequence similaritiesi

Belongs to the OmpA family. Pal subfamily.Curated
Contains 1 OmpA-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105KCK. Bacteria.
COG2885. LUCA.
HOGENOMiHOG000189913.
InParanoidiP0A912.
KOiK03640.
OMAiRLMIEGH.
PhylomeDBiP0A912.

Family and domain databases

CDDicd07185. OmpA_C-like. 1 hit.
Gene3Di3.30.1330.60. 1 hit.
InterProiIPR006664. OMP_bac.
IPR006665. OmpA-like.
IPR006690. OMPA-like_CS.
IPR014169. Pal_lipo.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
SUPFAMiSSF103088. SSF103088. 1 hit.
TIGRFAMsiTIGR02802. Pal_lipo. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLNKVLKGL MIALPVMAIA ACSSNKNASN DGSEGMLGAG TGMDANGGNG
60 70 80 90 100
NMSSEEQARL QMQQLQQNNI VYFDLDKYDI RSDFAQMLDA HANFLRSNPS
110 120 130 140 150
YKVTVEGHAD ERGTPEYNIS LGERRANAVK MYLQGKGVSA DQISIVSYGK
160 170
EKPAVLGHDE AAYSKNRRAV LVY
Length:173
Mass (Da):18,824
Last modified:April 1, 1988 - v1
Checksum:i449F9959C0274430
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05123 Genomic DNA. Translation: CAA28771.1.
X65796 Genomic DNA. Translation: CAA46673.1.
U00096 Genomic DNA. Translation: AAC73835.1.
AP009048 Genomic DNA. Translation: BAA35407.1.
M28232 Genomic DNA. No translation available.
PIRiA27534. LPECPG.
RefSeqiNP_415269.1. NC_000913.3.
WP_001295306.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73835; AAC73835; b0741.
BAA35407; BAA35407; BAA35407.
GeneIDi945004.
KEGGiecj:JW0731.
eco:b0741.
PATRICi32116681. VBIEscCol129921_0773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05123 Genomic DNA. Translation: CAA28771.1.
X65796 Genomic DNA. Translation: CAA46673.1.
U00096 Genomic DNA. Translation: AAC73835.1.
AP009048 Genomic DNA. Translation: BAA35407.1.
M28232 Genomic DNA. No translation available.
PIRiA27534. LPECPG.
RefSeqiNP_415269.1. NC_000913.3.
WP_001295306.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OAPX-ray1.93A65-173[»]
2HQSX-ray1.50C/E/G/H65-173[»]
2W8BX-ray1.86C/E/G/H65-173[»]
ProteinModelPortaliP0A912.
SMRiP0A912.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260724. 230 interactors.
DIPiDIP-51001N.
IntActiP0A912. 8 interactors.
MINTiMINT-7259928.
STRINGi511145.b0741.

Proteomic databases

EPDiP0A912.
PaxDbiP0A912.
PRIDEiP0A912.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73835; AAC73835; b0741.
BAA35407; BAA35407; BAA35407.
GeneIDi945004.
KEGGiecj:JW0731.
eco:b0741.
PATRICi32116681. VBIEscCol129921_0773.

Organism-specific databases

EchoBASEiEB0678.
EcoGeneiEG10684. pal.

Phylogenomic databases

eggNOGiENOG4105KCK. Bacteria.
COG2885. LUCA.
HOGENOMiHOG000189913.
InParanoidiP0A912.
KOiK03640.
OMAiRLMIEGH.
PhylomeDBiP0A912.

Enzyme and pathway databases

BioCyciEcoCyc:EG10684-MONOMER.
ECOL316407:JW0731-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A912.
PROiP0A912.

Family and domain databases

CDDicd07185. OmpA_C-like. 1 hit.
Gene3Di3.30.1330.60. 1 hit.
InterProiIPR006664. OMP_bac.
IPR006665. OmpA-like.
IPR006690. OMPA-like_CS.
IPR014169. Pal_lipo.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
SUPFAMiSSF103088. SSF103088. 1 hit.
TIGRFAMsiTIGR02802. Pal_lipo. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAL_ECOLI
AccessioniPrimary (citable) accession number: P0A912
Secondary accession number(s): P07176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.