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Protein

Outer membrane protein A

Gene

ompA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Conjugation, Ion transport, Transport

Enzyme and pathway databases

BioCyciECOO157:OMPA-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein A
Alternative name(s):
Outer membrane protein II*
Gene namesi
Name:ompA
Ordered Locus Names:Z1307, ECs1041
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 26PeriplasmicBy similarity5
Transmembranei27 – 37Beta strandedBy similarityAdd BLAST11
Topological domaini38 – 54ExtracellularBy similarityAdd BLAST17
Transmembranei55 – 66Beta strandedBy similarityAdd BLAST12
Topological domaini67 – 69PeriplasmicBy similarity3
Transmembranei70 – 78Beta strandedBy similarity9
Topological domaini79 – 95ExtracellularBy similarityAdd BLAST17
Transmembranei96 – 107Beta strandedBy similarityAdd BLAST12
Topological domaini108 – 111PeriplasmicBy similarity4
Transmembranei112 – 124Beta strandedBy similarityAdd BLAST13
Topological domaini125 – 137ExtracellularBy similarityAdd BLAST13
Transmembranei138 – 151Beta strandedBy similarityAdd BLAST14
Topological domaini152 – 155PeriplasmicBy similarity4
Transmembranei156 – 163Beta strandedBy similarity8
Topological domaini164 – 181ExtracellularBy similarityAdd BLAST18
Transmembranei182 – 190Beta strandedBy similarity9
Topological domaini191 – 346PeriplasmicBy similarityAdd BLAST156

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000002009522 – 346Outer membrane protein AAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi311 ↔ 323By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP0A911.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi155864.Z1307.

Structurei

3D structure databases

ProteinModelPortaliP0A911.
SMRiP0A911.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati201 – 20212
Repeati203 – 20422
Repeati205 – 20632
Repeati207 – 20842
Domaini210 – 338OmpA-likePROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni197 – 208Hinge-likeAdd BLAST12
Regioni201 – 2084 X 2 AA tandem repeats of A-P8

Sequence similaritiesi

Belongs to the OmpA family.Curated
Contains 1 OmpA-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105UYK. Bacteria.
COG2885. LUCA.
HOGENOMiHOG000274199.
KOiK03286.
OMAiEYALTKN.

Family and domain databases

CDDicd07185. OmpA_C-like. 1 hit.
Gene3Di2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006665. OmpA-like.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMiSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTAIAIAV ALAGFATVAQ AAPKDNTWYT GAKLGWSQYH DTGFINNNGP
60 70 80 90 100
THENQLGAGA FGGYQVNPYV GFEMGYDWLG RMPYKGSVEN GAYKAQGVQL
110 120 130 140 150
TAKLGYPITD DLDIYTRLGG MVWRADTKSN VYGKNHDTGV SPVFAGGVEY
160 170 180 190 200
AITPEIATRL EYQWTNNIGD AHTIGTRPDN GMLSLGVSYR FGQGEAAPVV
210 220 230 240 250
APAPAPAPEV QTKHFTLKSD VLFNFNKATL KPEGQAALDQ LYSQLSNLDP
260 270 280 290 300
KDGSVVVLGY TDRIGSDAYN QGLSERRAQS VVDYLISKGI PADKISARGM
310 320 330 340
GESNPVTGNT CDNVKQRAAL IDCLAPDRRV EIEVKGIKDV VTQPQA
Length:346
Mass (Da):37,201
Last modified:July 21, 1986 - v1
Checksum:i195147734CDF8B04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55443.1.
BA000007 Genomic DNA. Translation: BAB34464.1.
PIRiA90759.
G85622.
RefSeqiNP_309068.1. NC_002695.1.
WP_000750416.1. NZ_LPWC02000004.1.

Genome annotation databases

EnsemblBacteriaiAAG55443; AAG55443; Z1307.
BAB34464; BAB34464; BAB34464.
GeneIDi917123.
KEGGiece:Z1307.
ecs:ECs1041.
PATRICi18351349. VBIEscCol44059_1178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG55443.1.
BA000007 Genomic DNA. Translation: BAB34464.1.
PIRiA90759.
G85622.
RefSeqiNP_309068.1. NC_002695.1.
WP_000750416.1. NZ_LPWC02000004.1.

3D structure databases

ProteinModelPortaliP0A911.
SMRiP0A911.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z1307.

Proteomic databases

PRIDEiP0A911.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG55443; AAG55443; Z1307.
BAB34464; BAB34464; BAB34464.
GeneIDi917123.
KEGGiece:Z1307.
ecs:ECs1041.
PATRICi18351349. VBIEscCol44059_1178.

Phylogenomic databases

eggNOGiENOG4105UYK. Bacteria.
COG2885. LUCA.
HOGENOMiHOG000274199.
KOiK03286.
OMAiEYALTKN.

Enzyme and pathway databases

BioCyciECOO157:OMPA-MONOMER.

Family and domain databases

CDDicd07185. OmpA_C-like. 1 hit.
Gene3Di2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006665. OmpA-like.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMiSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMPA_ECO57
AccessioniPrimary (citable) accession number: P0A911
Secondary accession number(s): P02934
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.