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Protein

Outer membrane protein A

Gene

ompA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPorin
Biological processConjugation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein A
Alternative name(s):
Outer membrane protein II*
Gene namesi
Name:ompA
Ordered Locus Names:Z1307, ECs1041
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 26PeriplasmicBy similarity5
Transmembranei27 – 37Beta strandedBy similarityAdd BLAST11
Topological domaini38 – 54ExtracellularBy similarityAdd BLAST17
Transmembranei55 – 66Beta strandedBy similarityAdd BLAST12
Topological domaini67 – 69PeriplasmicBy similarity3
Transmembranei70 – 78Beta strandedBy similarity9
Topological domaini79 – 95ExtracellularBy similarityAdd BLAST17
Transmembranei96 – 107Beta strandedBy similarityAdd BLAST12
Topological domaini108 – 111PeriplasmicBy similarity4
Transmembranei112 – 124Beta strandedBy similarityAdd BLAST13
Topological domaini125 – 137ExtracellularBy similarityAdd BLAST13
Transmembranei138 – 151Beta strandedBy similarityAdd BLAST14
Topological domaini152 – 155PeriplasmicBy similarity4
Transmembranei156 – 163Beta strandedBy similarity8
Topological domaini164 – 181ExtracellularBy similarityAdd BLAST18
Transmembranei182 – 190Beta strandedBy similarity9
Topological domaini191 – 346PeriplasmicBy similarityAdd BLAST156

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000002009522 – 346Outer membrane protein AAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi311 ↔ 323By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP0A911

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi155864.Z1307

Structurei

3D structure databases

ProteinModelPortaliP0A911
SMRiP0A911
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati201 – 20212
Repeati203 – 20422
Repeati205 – 20632
Repeati207 – 20842
Domaini210 – 338OmpA-likePROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni197 – 208Hinge-likeAdd BLAST12
Regioni201 – 2084 X 2 AA tandem repeats of A-P8

Sequence similaritiesi

Belongs to the OmpA family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105UYK Bacteria
COG2885 LUCA
HOGENOMiHOG000274199
KOiK03286
OMAiHDTGFYG

Family and domain databases

CDDicd07185 OmpA_C-like, 1 hit
Gene3Di3.30.1330.60, 1 hit
InterProiView protein in InterPro
IPR011250 OMP/PagP_b-brl
IPR006664 OMP_bac
IPR002368 OmpA
IPR006665 OmpA-like
IPR006690 OMPA-like_CS
IPR036737 OmpA-like_sf
IPR000498 OmpA-like_TM_dom
PfamiView protein in Pfam
PF00691 OmpA, 1 hit
PF01389 OmpA_membrane, 1 hit
PRINTSiPR01021 OMPADOMAIN
PR01022 OUTRMMBRANEA
SUPFAMiSSF103088 SSF103088, 1 hit
SSF56925 SSF56925, 1 hit
PROSITEiView protein in PROSITE
PS01068 OMPA_1, 1 hit
PS51123 OMPA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTAIAIAV ALAGFATVAQ AAPKDNTWYT GAKLGWSQYH DTGFINNNGP
60 70 80 90 100
THENQLGAGA FGGYQVNPYV GFEMGYDWLG RMPYKGSVEN GAYKAQGVQL
110 120 130 140 150
TAKLGYPITD DLDIYTRLGG MVWRADTKSN VYGKNHDTGV SPVFAGGVEY
160 170 180 190 200
AITPEIATRL EYQWTNNIGD AHTIGTRPDN GMLSLGVSYR FGQGEAAPVV
210 220 230 240 250
APAPAPAPEV QTKHFTLKSD VLFNFNKATL KPEGQAALDQ LYSQLSNLDP
260 270 280 290 300
KDGSVVVLGY TDRIGSDAYN QGLSERRAQS VVDYLISKGI PADKISARGM
310 320 330 340
GESNPVTGNT CDNVKQRAAL IDCLAPDRRV EIEVKGIKDV VTQPQA
Length:346
Mass (Da):37,201
Last modified:July 21, 1986 - v1
Checksum:i195147734CDF8B04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55443.1
BA000007 Genomic DNA Translation: BAB34464.1
PIRiA90759
G85622
RefSeqiNP_309068.1, NC_002695.1
WP_000750416.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG55443; AAG55443; Z1307
BAB34464; BAB34464; BAB34464
GeneIDi917123
KEGGiece:Z1307
ecs:ECs1041
PATRICifig|386585.9.peg.1165

Similar proteinsi

Entry informationi

Entry nameiOMPA_ECO57
AccessioniPrimary (citable) accession number: P0A911
Secondary accession number(s): P02934
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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