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P0A911 (OMPA_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Outer membrane protein A
Alternative name(s):
Outer membrane protein II*
Gene names
Name:ompA
Ordered Locus Names:Z1307, ECs1041
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Cell outer membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the OmpA family.

Contains 1 OmpA-like domain.

Ontologies

Keywords
   Biological processConjugation
Ion transport
Transport
   Cellular componentCell membrane
Cell outer membrane
Membrane
   DomainRepeat
Signal
Transmembrane
Transmembrane beta strand
   Molecular functionPorin
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processconjugation

Inferred from electronic annotation. Source: UniProtKB-KW

ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

pore complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionporin activity

Inferred from electronic annotation. Source: UniProtKB-KW

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 346325Outer membrane protein A
PRO_0000020095

Regions

Topological domain22 – 265Periplasmic By similarity
Transmembrane27 – 3711Beta stranded; By similarity
Topological domain38 – 5417Extracellular By similarity
Transmembrane55 – 6612Beta stranded; By similarity
Topological domain67 – 693Periplasmic By similarity
Transmembrane70 – 789Beta stranded; By similarity
Topological domain79 – 9517Extracellular By similarity
Transmembrane96 – 10712Beta stranded; By similarity
Topological domain108 – 1114Periplasmic By similarity
Transmembrane112 – 12413Beta stranded; By similarity
Topological domain125 – 13713Extracellular By similarity
Transmembrane138 – 15114Beta stranded; By similarity
Topological domain152 – 1554Periplasmic By similarity
Transmembrane156 – 1638Beta stranded; By similarity
Topological domain164 – 18118Extracellular By similarity
Transmembrane182 – 1909Beta stranded; By similarity
Topological domain191 – 346156Periplasmic By similarity
Repeat201 – 20221
Repeat203 – 20422
Repeat205 – 20623
Repeat207 – 20824
Domain210 – 338129OmpA-like
Region197 – 20812Hinge-like
Region201 – 20884 X 2 AA tandem repeats of A-P

Amino acid modifications

Disulfide bond311 ↔ 323 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A911 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 195147734CDF8B04

FASTA34637,201
        10         20         30         40         50         60 
MKKTAIAIAV ALAGFATVAQ AAPKDNTWYT GAKLGWSQYH DTGFINNNGP THENQLGAGA 

        70         80         90        100        110        120 
FGGYQVNPYV GFEMGYDWLG RMPYKGSVEN GAYKAQGVQL TAKLGYPITD DLDIYTRLGG 

       130        140        150        160        170        180 
MVWRADTKSN VYGKNHDTGV SPVFAGGVEY AITPEIATRL EYQWTNNIGD AHTIGTRPDN 

       190        200        210        220        230        240 
GMLSLGVSYR FGQGEAAPVV APAPAPAPEV QTKHFTLKSD VLFNFNKATL KPEGQAALDQ 

       250        260        270        280        290        300 
LYSQLSNLDP KDGSVVVLGY TDRIGSDAYN QGLSERRAQS VVDYLISKGI PADKISARGM 

       310        320        330        340 
GESNPVTGNT CDNVKQRAAL IDCLAPDRRV EIEVKGIKDV VTQPQA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005174 Genomic DNA. Translation: AAG55443.1.
BA000007 Genomic DNA. Translation: BAB34464.1.
PIRA90759.
G85622.
RefSeqNP_286832.1. NC_002655.2.
NP_309068.1. NC_002695.1.

3D structure databases

ProteinModelPortalP0A911.
SMRP0A911. Positions 22-192, 209-337.
ModBaseSearch...

Protein-protein interaction databases

STRING155864.Z1307.

Proteomic databases

PRIDEP0A911.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG55443; AAG55443; Z1307.
BAB34464; BAB34464; BAB34464.
GeneID917123.
958948.
KEGGece:Z1307.
ecs:ECs1041.
PATRIC18351349. VBIEscCol44059_1178.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2885.
HOGENOMHOG000274199.
KOK03286.
OMADDNEAQK.
ProtClustDBPRK10808.

Enzyme and pathway databases

BioCycECOL386585:GJFA-1037-MONOMER.

Family and domain databases

Gene3D2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
IPR006665. OmpA/MotB_C.
[Graphical view]
PfamPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMSSF103088. OmpA/MotB_C. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOMPA_ECO57
AccessionPrimary (citable) accession number: P0A911
Secondary accession number(s): P02934
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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