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Protein

Outer membrane lipoprotein Blc

Gene

blc

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7837-MONOMER.
ECOL316407:JW4110-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane lipoprotein Blc
Gene namesi
Name:blc
Synonyms:yjeL
Ordered Locus Names:b4149, JW4110
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12474. blc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
ChainiPRO_000001799119 – 177Outer membrane lipoprotein BlcAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi19N-palmitoyl cysteineCurated1
Lipidationi19S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiP0A901.
PaxDbiP0A901.
PRIDEiP0A901.

Expressioni

Inductioni

By starvation and high osmolarity.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi4261278. 189 interactors.
DIPiDIP-35862N.
IntActiP0A901. 6 interactors.
STRINGi511145.b4149.

Structurei

Secondary structure

1177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 33Combined sources6
Helixi36 – 39Combined sources4
Beta strandi41 – 48Combined sources8
Helixi52 – 54Combined sources3
Beta strandi58 – 66Combined sources9
Beta strandi72 – 80Combined sources9
Turni81 – 84Combined sources4
Beta strandi85 – 97Combined sources13
Beta strandi103 – 109Combined sources7
Beta strandi112 – 122Combined sources11
Beta strandi125 – 131Combined sources7
Beta strandi138 – 146Combined sources9
Helixi149 – 161Combined sources13
Helixi166 – 168Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QWDX-ray1.75A/B23-177[»]
2ACOX-ray1.80A/B23-177[»]
3MBTX-ray2.60A19-177[»]
ProteinModelPortaliP0A901.
SMRiP0A901.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A901.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105QNF. Bacteria.
COG3040. LUCA.
HOGENOMiHOG000061524.
InParanoidiP0A901.
KOiK03098.
OMAiVINRGFN.
PhylomeDBiP0A901.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR022271. Lipocalin_ApoD.
IPR002446. Lipocalin_bac.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF08212. Lipocalin_2. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSiPR01171. BCTLIPOCALIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLPLVAAA TAAFLVVACS SPTPPRGVTV VNNFDAKRYL GTWYEIARFD
60 70 80 90 100
HRFERGLEKV TATYSLRDDG GLNVINKGYN PDRGMWQQSE GKAYFTGAPT
110 120 130 140 150
RAALKVSFFG PFYGGYNVIA LDREYRHALV CGPDRDYLWI LSRTPTISDE
160 170
VKQEMLAVAT REGFDVSKFI WVQQPGS
Length:177
Mass (Da):19,852
Last modified:July 19, 2005 - v1
Checksum:iBFF9A53A099B0048
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21726 Genomic DNA. Translation: AAC46452.1.
U14003 Genomic DNA. Translation: AAA97048.1.
U00096 Genomic DNA. Translation: AAC77109.1.
AP009048 Genomic DNA. Translation: BAE78153.1.
PIRiI84534.
RefSeqiNP_418573.1. NC_000913.3.
WP_001238378.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77109; AAC77109; b4149.
BAE78153; BAE78153; BAE78153.
GeneIDi948670.
KEGGiecj:JW4110.
eco:b4149.
PATRICi32123871. VBIEscCol129921_4283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21726 Genomic DNA. Translation: AAC46452.1.
U14003 Genomic DNA. Translation: AAA97048.1.
U00096 Genomic DNA. Translation: AAC77109.1.
AP009048 Genomic DNA. Translation: BAE78153.1.
PIRiI84534.
RefSeqiNP_418573.1. NC_000913.3.
WP_001238378.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QWDX-ray1.75A/B23-177[»]
2ACOX-ray1.80A/B23-177[»]
3MBTX-ray2.60A19-177[»]
ProteinModelPortaliP0A901.
SMRiP0A901.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261278. 189 interactors.
DIPiDIP-35862N.
IntActiP0A901. 6 interactors.
STRINGi511145.b4149.

Proteomic databases

EPDiP0A901.
PaxDbiP0A901.
PRIDEiP0A901.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77109; AAC77109; b4149.
BAE78153; BAE78153; BAE78153.
GeneIDi948670.
KEGGiecj:JW4110.
eco:b4149.
PATRICi32123871. VBIEscCol129921_4283.

Organism-specific databases

EchoBASEiEB2367.
EcoGeneiEG12474. blc.

Phylogenomic databases

eggNOGiENOG4105QNF. Bacteria.
COG3040. LUCA.
HOGENOMiHOG000061524.
InParanoidiP0A901.
KOiK03098.
OMAiVINRGFN.
PhylomeDBiP0A901.

Enzyme and pathway databases

BioCyciEcoCyc:G7837-MONOMER.
ECOL316407:JW4110-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A901.
PROiP0A901.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR022271. Lipocalin_ApoD.
IPR002446. Lipocalin_bac.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF08212. Lipocalin_2. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSiPR01171. BCTLIPOCALIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBLC_ECOLI
AccessioniPrimary (citable) accession number: P0A901
Secondary accession number(s): P39281, Q2M6F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.