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Protein

Acyl-CoA thioester hydrolase YbgC

Gene

ybgC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Thioesterase that appears to be involved in phospholipid metabolism. Some specific acyl-ACPs could be physiological substrates. Displays acyl-CoA thioesterase activity on malonyl-CoA in vitro, catalyzing the hydrolysis of the thioester bond.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei18PROSITE-ProRule annotation1

GO - Molecular functioni

  • thiolester hydrolase activity Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:EG11110-MONOMER.
ECOL316407:JW0726-MONOMER.
BRENDAi3.1.2.2. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA thioester hydrolase YbgC (EC:3.1.2.-)
Short name:
Acyl-CoA thioesterase
Gene namesi
Name:ybgC
Ordered Locus Names:b0736, JW0726
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11110. ybgC.

Subcellular locationi

  • Cell inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000877621 – 134Acyl-CoA thioester hydrolase YbgCAdd BLAST134

Proteomic databases

PaxDbiP0A8Z3.
PRIDEiP0A8Z3.

Interactioni

Subunit structurei

Interacts with ACP, PlsB and PssA, forming altogether a complex at the inner membrane.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
acpPP0A6A86EBI-543276,EBI-542566
espPO325912EBI-543276,EBI-852989From a different organism.
secAP104082EBI-543276,EBI-543213

Protein-protein interaction databases

BioGridi4259452. 197 interactors.
DIPiDIP-29375N.
IntActiP0A8Z3. 11 interactors.
MINTiMINT-1222012.
STRINGi511145.b0736.

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Helixi14 – 16Combined sources3
Beta strandi21 – 23Combined sources3
Helixi25 – 42Combined sources18
Helixi47 – 52Combined sources6
Beta strandi56 – 66Combined sources11
Beta strandi75 – 85Combined sources11
Beta strandi87 – 97Combined sources11
Beta strandi103 – 115Combined sources13
Turni116 – 119Combined sources4
Helixi126 – 131Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S5UX-ray1.70A/B/C/D/E/F/G/H1-134[»]
5KL9X-ray2.22A/B/C/D1-134[»]
5T06X-ray1.90A/B/C/D2-134[»]
5T07X-ray1.72A/B/C/D2-134[»]
ProteinModelPortaliP0A8Z3.
SMRiP0A8Z3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A8Z3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107YD3. Bacteria.
COG0824. LUCA.
HOGENOMiHOG000004132.
InParanoidiP0A8Z3.
KOiK07107.
OMAiELGFAQS.
PhylomeDBiP0A8Z3.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
InterProiIPR008272. HB-CoA_thioesterase_AS.
IPR029069. HotDog_dom.
IPR006683. Thioestr_dom.
IPR014166. Tol-Pal_acyl-CoA_thioesterase.
IPR006684. YbgC/YbaW.
[Graphical view]
PfamiPF03061. 4HBT. 1 hit.
[Graphical view]
PIRSFiPIRSF003230. YbgC. 1 hit.
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR02799. thio_ybgC. 1 hit.
TIGR00051. TIGR00051. 1 hit.
PROSITEiPS01328. 4HBCOA_THIOESTERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A8Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTLFRWPV RVYYEDTDAG GVVYHASYVA FYERARTEML RHHHFSQQAL
60 70 80 90 100
MAERVAFVVR KMTVEYYAPA RLDDMLEIQT EITSMRGTSL VFTQRIVNAE
110 120 130
NTLLNEAEVL VVCVDPLKMK PRALPKSIVA EFKQ
Length:134
Mass (Da):15,562
Last modified:June 21, 2005 - v1
Checksum:iC44582B6EC3BE989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16489 Genomic DNA. Translation: AAA83918.1.
U00096 Genomic DNA. Translation: AAC73830.1.
AP009048 Genomic DNA. Translation: BAA35402.1.
U30934 Genomic DNA. Translation: AAA74398.1.
PIRiA25980. WMEC15.
RefSeqiNP_415264.1. NC_000913.3.
WP_001098384.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73830; AAC73830; b0736.
BAA35402; BAA35402; BAA35402.
GeneIDi948907.
KEGGiecj:JW0726.
eco:b0736.
PATRICi32116671. VBIEscCol129921_0768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16489 Genomic DNA. Translation: AAA83918.1.
U00096 Genomic DNA. Translation: AAC73830.1.
AP009048 Genomic DNA. Translation: BAA35402.1.
U30934 Genomic DNA. Translation: AAA74398.1.
PIRiA25980. WMEC15.
RefSeqiNP_415264.1. NC_000913.3.
WP_001098384.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S5UX-ray1.70A/B/C/D/E/F/G/H1-134[»]
5KL9X-ray2.22A/B/C/D1-134[»]
5T06X-ray1.90A/B/C/D2-134[»]
5T07X-ray1.72A/B/C/D2-134[»]
ProteinModelPortaliP0A8Z3.
SMRiP0A8Z3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259452. 197 interactors.
DIPiDIP-29375N.
IntActiP0A8Z3. 11 interactors.
MINTiMINT-1222012.
STRINGi511145.b0736.

Proteomic databases

PaxDbiP0A8Z3.
PRIDEiP0A8Z3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73830; AAC73830; b0736.
BAA35402; BAA35402; BAA35402.
GeneIDi948907.
KEGGiecj:JW0726.
eco:b0736.
PATRICi32116671. VBIEscCol129921_0768.

Organism-specific databases

EchoBASEiEB1101.
EcoGeneiEG11110. ybgC.

Phylogenomic databases

eggNOGiENOG4107YD3. Bacteria.
COG0824. LUCA.
HOGENOMiHOG000004132.
InParanoidiP0A8Z3.
KOiK07107.
OMAiELGFAQS.
PhylomeDBiP0A8Z3.

Enzyme and pathway databases

BioCyciEcoCyc:EG11110-MONOMER.
ECOL316407:JW0726-MONOMER.
BRENDAi3.1.2.2. 2026.

Miscellaneous databases

EvolutionaryTraceiP0A8Z3.
PROiP0A8Z3.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
InterProiIPR008272. HB-CoA_thioesterase_AS.
IPR029069. HotDog_dom.
IPR006683. Thioestr_dom.
IPR014166. Tol-Pal_acyl-CoA_thioesterase.
IPR006684. YbgC/YbaW.
[Graphical view]
PfamiPF03061. 4HBT. 1 hit.
[Graphical view]
PIRSFiPIRSF003230. YbgC. 1 hit.
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR02799. thio_ybgC. 1 hit.
TIGR00051. TIGR00051. 1 hit.
PROSITEiPS01328. 4HBCOA_THIOESTERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYBGC_ECOLI
AccessioniPrimary (citable) accession number: P0A8Z3
Secondary accession number(s): P08999
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.