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Protein

Acyl-CoA thioester hydrolase YbgC

Gene

ybgC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thioesterase that appears to be involved in phospholipid metabolism. Some specific acyl-ACPs could be physiological substrates. Displays acyl-CoA thioesterase activity on malonyl-CoA in vitro, catalyzing the hydrolysis of the thioester bond.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei18PROSITE-ProRule annotation1

GO - Molecular functioni

  • thiolester hydrolase activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:EG11110-MONOMER
BRENDAi3.1.2.2 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA thioester hydrolase YbgC (EC:3.1.2.-)
Short name:
Acyl-CoA thioesterase
Gene namesi
Name:ybgC
Ordered Locus Names:b0736, JW0726
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11110 ybgC

Subcellular locationi

  • Cell inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000877621 – 134Acyl-CoA thioester hydrolase YbgCAdd BLAST134

Proteomic databases

PaxDbiP0A8Z3
PRIDEiP0A8Z3

Interactioni

Subunit structurei

Interacts with ACP, PlsB and PssA, forming altogether a complex at the inner membrane.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4259452, 197 interactors
DIPiDIP-29375N
IntActiP0A8Z3, 11 interactors
STRINGi316385.ECDH10B_0803

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Helixi14 – 16Combined sources3
Beta strandi21 – 23Combined sources3
Helixi25 – 42Combined sources18
Helixi47 – 52Combined sources6
Beta strandi56 – 66Combined sources11
Beta strandi75 – 85Combined sources11
Beta strandi87 – 97Combined sources11
Beta strandi103 – 115Combined sources13
Turni116 – 119Combined sources4
Helixi126 – 131Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S5UX-ray1.70A/B/C/D/E/F/G/H1-134[»]
5KL9X-ray2.22A/B/C/D1-134[»]
5T06X-ray1.90A/B/C/D2-134[»]
5T07X-ray1.72A/B/C/D2-134[»]
ProteinModelPortaliP0A8Z3
SMRiP0A8Z3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A8Z3

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107YD3 Bacteria
COG0824 LUCA
HOGENOMiHOG000004132
InParanoidiP0A8Z3
KOiK07107
OMAiYHARYLE
PhylomeDBiP0A8Z3

Family and domain databases

InterProiView protein in InterPro
IPR008272 HB-CoA_thioesterase_AS
IPR029069 HotDog_dom_sf
IPR006683 Thioestr_dom
IPR014166 Tol-Pal_acyl-CoA_thioesterase
IPR006684 YbgC/YbaW
PfamiView protein in Pfam
PF03061 4HBT, 1 hit
PIRSFiPIRSF003230 YbgC, 1 hit
SUPFAMiSSF54637 SSF54637, 1 hit
TIGRFAMsiTIGR02799 thio_ybgC, 1 hit
TIGR00051 TIGR00051, 1 hit
PROSITEiView protein in PROSITE
PS01328 4HBCOA_THIOESTERASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A8Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTLFRWPV RVYYEDTDAG GVVYHASYVA FYERARTEML RHHHFSQQAL
60 70 80 90 100
MAERVAFVVR KMTVEYYAPA RLDDMLEIQT EITSMRGTSL VFTQRIVNAE
110 120 130
NTLLNEAEVL VVCVDPLKMK PRALPKSIVA EFKQ
Length:134
Mass (Da):15,562
Last modified:June 21, 2005 - v1
Checksum:iC44582B6EC3BE989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16489 Genomic DNA Translation: AAA83918.1
U00096 Genomic DNA Translation: AAC73830.1
AP009048 Genomic DNA Translation: BAA35402.1
U30934 Genomic DNA Translation: AAA74398.1
PIRiA25980 WMEC15
RefSeqiNP_415264.1, NC_000913.3
WP_001098384.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73830; AAC73830; b0736
BAA35402; BAA35402; BAA35402
GeneIDi948907
KEGGiecj:JW0726
eco:b0736
PATRICifig|1411691.4.peg.1536

Similar proteinsi

Entry informationi

Entry nameiYBGC_ECOLI
AccessioniPrimary (citable) accession number: P0A8Z3
Secondary accession number(s): P08999
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health