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Protein

Acyl-CoA thioester hydrolase YciA

Gene

yciA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA.1 Publication

GO - Molecular functioni

  • acyl-CoA hydrolase activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciEcoCyc:EG11121-MONOMER
MetaCyc:EG11121-MONOMER
BRENDAi3.1.2.2 2026
3.1.2.20 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA thioester hydrolase YciA (EC:3.1.2.-)
Alternative name(s):
Protein P14
Gene namesi
Name:yciA
Ordered Locus Names:b1253, JW1245
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11121 yciA

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538171 – 132Acyl-CoA thioester hydrolase YciAAdd BLAST132

Proteomic databases

PaxDbiP0A8Z0
PRIDEiP0A8Z0

Interactioni

Protein-protein interaction databases

BioGridi4262997, 21 interactors
DIPiDIP-35956N
IntActiP0A8Z0, 14 interactors
STRINGi316385.ECDH10B_1368

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G6Smodel-A1-132[»]
ProteinModelPortaliP0A8Z0
SMRiP0A8Z0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 123HotDog ACOT-typePROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Belongs to the acyl coenzyme A hydrolase family.Curated

Phylogenomic databases

eggNOGiENOG4105NAU Bacteria
COG1607 LUCA
HOGENOMiHOG000044841
InParanoidiP0A8Z0
KOiK10806
OMAiIYTFVAV
PhylomeDBiP0A8Z0

Family and domain databases

InterProiView protein in InterPro
IPR033120 HOTDOG_ACOT
IPR029069 HotDog_dom_sf
IPR006683 Thioestr_dom
PfamiView protein in Pfam
PF03061 4HBT, 1 hit
SUPFAMiSSF54637 SSF54637, 1 hit
PROSITEiView protein in PROSITE
PS51770 HOTDOG_ACOT, 1 hit

Sequencei

Sequence statusi: Complete.

P0A8Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTHNVPQG DLVLRTLAMP ADTNANGDIF GGWLMSQMDI GGAILAKEIA
60 70 80 90 100
HGRVVTVRVE GMTFLRPVAV GDVVCCYARC VQKGTTSVSI NIEVWVKKVA
110 120 130
SEPIGQRYKA TEALFKYVAV DPEGKPRALP VE
Length:132
Mass (Da):14,231
Last modified:March 20, 1987 - v1
Checksum:iEF29C49DBB6B50DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00431 Genomic DNA Translation: AAB59067.1
U24195 Genomic DNA Translation: AAB60068.1
U24196 Genomic DNA Translation: AAB60076.1
U24197 Genomic DNA Translation: AAB60084.1
U24198 Genomic DNA Translation: AAB60092.1
U24199 Genomic DNA Translation: AAB60100.1
U24200 Genomic DNA Translation: AAB60108.1
U24201 Genomic DNA Translation: AAB60116.1
U24202 Genomic DNA Translation: AAB60124.1
U24203 Genomic DNA Translation: AAB60132.1
U24204 Genomic DNA Translation: AAB60140.1
U24205 Genomic DNA Translation: AAB60148.1
U24206 Genomic DNA Translation: AAB60156.1
U00096 Genomic DNA Translation: AAC74335.1
AP009048 Genomic DNA Translation: BAA14785.1
PIRiA05224
RefSeqiNP_415769.1, NC_000913.3
WP_000108160.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74335; AAC74335; b1253
BAA14785; BAA14785; BAA14785
GeneIDi946634
KEGGiecj:JW1245
eco:b1253
PATRICifig|1411691.4.peg.1030

Similar proteinsi

Entry informationi

Entry nameiYCIA_ECOLI
AccessioniPrimary (citable) accession number: P0A8Z0
Secondary accession number(s): P04379
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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