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Protein

Acyl-CoA thioester hydrolase YciA

Gene

yciA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA.1 Publication

GO - Molecular functioni

  • acyl-CoA hydrolase activity Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciEcoCyc:EG11121-MONOMER.
ECOL316407:JW1245-MONOMER.
MetaCyc:EG11121-MONOMER.
BRENDAi3.1.2.2. 2026.
3.1.2.20. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA thioester hydrolase YciA (EC:3.1.2.-)
Alternative name(s):
Protein P14
Gene namesi
Name:yciA
Ordered Locus Names:b1253, JW1245
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11121. yciA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538171 – 132Acyl-CoA thioester hydrolase YciAAdd BLAST132

Proteomic databases

PaxDbiP0A8Z0.
PRIDEiP0A8Z0.

Interactioni

Protein-protein interaction databases

BioGridi4262997. 15 interactors.
DIPiDIP-35956N.
IntActiP0A8Z0. 14 interactors.
STRINGi511145.b1253.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G6Smodel-A1-132[»]
ProteinModelPortaliP0A8Z0.
SMRiP0A8Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 123HotDog ACOT-typePROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Belongs to the acyl coenzyme A hydrolase family.Curated
Contains 1 HotDog ACOT-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105NAU. Bacteria.
COG1607. LUCA.
HOGENOMiHOG000044841.
InParanoidiP0A8Z0.
KOiK10806.
OMAiVNVEVWV.
PhylomeDBiP0A8Z0.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
InterProiIPR033120. HOTDOG_ACOT.
IPR029069. HotDog_dom.
IPR006683. Thioestr_dom.
[Graphical view]
PfamiPF03061. 4HBT. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
PROSITEiPS51770. HOTDOG_ACOT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A8Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTHNVPQG DLVLRTLAMP ADTNANGDIF GGWLMSQMDI GGAILAKEIA
60 70 80 90 100
HGRVVTVRVE GMTFLRPVAV GDVVCCYARC VQKGTTSVSI NIEVWVKKVA
110 120 130
SEPIGQRYKA TEALFKYVAV DPEGKPRALP VE
Length:132
Mass (Da):14,231
Last modified:March 20, 1987 - v1
Checksum:iEF29C49DBB6B50DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00431 Genomic DNA. Translation: AAB59067.1.
U24195 Genomic DNA. Translation: AAB60068.1.
U24196 Genomic DNA. Translation: AAB60076.1.
U24197 Genomic DNA. Translation: AAB60084.1.
U24198 Genomic DNA. Translation: AAB60092.1.
U24199 Genomic DNA. Translation: AAB60100.1.
U24200 Genomic DNA. Translation: AAB60108.1.
U24201 Genomic DNA. Translation: AAB60116.1.
U24202 Genomic DNA. Translation: AAB60124.1.
U24203 Genomic DNA. Translation: AAB60132.1.
U24204 Genomic DNA. Translation: AAB60140.1.
U24205 Genomic DNA. Translation: AAB60148.1.
U24206 Genomic DNA. Translation: AAB60156.1.
U00096 Genomic DNA. Translation: AAC74335.1.
AP009048 Genomic DNA. Translation: BAA14785.1.
PIRiA05224.
RefSeqiNP_415769.1. NC_000913.3.
WP_000108160.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74335; AAC74335; b1253.
BAA14785; BAA14785; BAA14785.
GeneIDi946634.
KEGGiecj:JW1245.
eco:b1253.
PATRICi32117766. VBIEscCol129921_1303.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00431 Genomic DNA. Translation: AAB59067.1.
U24195 Genomic DNA. Translation: AAB60068.1.
U24196 Genomic DNA. Translation: AAB60076.1.
U24197 Genomic DNA. Translation: AAB60084.1.
U24198 Genomic DNA. Translation: AAB60092.1.
U24199 Genomic DNA. Translation: AAB60100.1.
U24200 Genomic DNA. Translation: AAB60108.1.
U24201 Genomic DNA. Translation: AAB60116.1.
U24202 Genomic DNA. Translation: AAB60124.1.
U24203 Genomic DNA. Translation: AAB60132.1.
U24204 Genomic DNA. Translation: AAB60140.1.
U24205 Genomic DNA. Translation: AAB60148.1.
U24206 Genomic DNA. Translation: AAB60156.1.
U00096 Genomic DNA. Translation: AAC74335.1.
AP009048 Genomic DNA. Translation: BAA14785.1.
PIRiA05224.
RefSeqiNP_415769.1. NC_000913.3.
WP_000108160.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G6Smodel-A1-132[»]
ProteinModelPortaliP0A8Z0.
SMRiP0A8Z0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262997. 15 interactors.
DIPiDIP-35956N.
IntActiP0A8Z0. 14 interactors.
STRINGi511145.b1253.

Proteomic databases

PaxDbiP0A8Z0.
PRIDEiP0A8Z0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74335; AAC74335; b1253.
BAA14785; BAA14785; BAA14785.
GeneIDi946634.
KEGGiecj:JW1245.
eco:b1253.
PATRICi32117766. VBIEscCol129921_1303.

Organism-specific databases

EchoBASEiEB1111.
EcoGeneiEG11121. yciA.

Phylogenomic databases

eggNOGiENOG4105NAU. Bacteria.
COG1607. LUCA.
HOGENOMiHOG000044841.
InParanoidiP0A8Z0.
KOiK10806.
OMAiVNVEVWV.
PhylomeDBiP0A8Z0.

Enzyme and pathway databases

BioCyciEcoCyc:EG11121-MONOMER.
ECOL316407:JW1245-MONOMER.
MetaCyc:EG11121-MONOMER.
BRENDAi3.1.2.2. 2026.
3.1.2.20. 2026.

Miscellaneous databases

PROiP0A8Z0.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
InterProiIPR033120. HOTDOG_ACOT.
IPR029069. HotDog_dom.
IPR006683. Thioestr_dom.
[Graphical view]
PfamiPF03061. 4HBT. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
PROSITEiPS51770. HOTDOG_ACOT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYCIA_ECOLI
AccessioniPrimary (citable) accession number: P0A8Z0
Secondary accession number(s): P04379
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.