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Protein

HTH-type transcriptional repressor NanR

Gene

nanR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids (PubMed:9864311, PubMed:12897000, PubMed:23935044). Represses expression of the nanATEK-yhcH, nanCMS and yjhBC operons. Acts by binding directly to the Nan box, a region of approximately 30 bp covering the promoter region (PubMed:23935044).3 Publications

Enzyme regulationi

N-acetylneuraminic acid (Neu5Ac) inactivates NanR by converting NanR oligomers to monomers.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi58 – 77H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7678-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor NanRUniRule annotationCurated
Gene namesi
Name:nanR1 PublicationUniRule annotation
Synonyms:yhcK
Ordered Locus Names:b3226, JW3195
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12817 nanR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506551 – 263HTH-type transcriptional repressor NanRAdd BLAST263

Proteomic databases

PaxDbiP0A8W0
PRIDEiP0A8W0

Interactioni

Subunit structurei

Homodimer (PubMed:12897000, PubMed:23935044). Might also form higher-order oligomers (PubMed:23935044).2 Publications

Protein-protein interaction databases

BioGridi4262443, 14 interactors
DIPiDIP-12284N
IntActiP0A8W0, 1 interactor
STRINGi316385.ECDH10B_3403

Structurei

3D structure databases

ProteinModelPortaliP0A8W0
SMRiP0A8W0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 98HTH gntR-typeUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the NanR family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4108QBF Bacteria
COG2186 LUCA
HOGENOMiHOG000273991
InParanoidiP0A8W0
KOiK22104
OMAiMLIWTGK
PhylomeDBiP0A8W0

Family and domain databases

CDDicd07377 WHTH_GntR, 1 hit
Gene3Di1.10.10.10, 1 hit
1.20.120.530, 1 hit
HAMAPiMF_01236 HTH_NanR, 1 hit
InterProiView protein in InterPro
IPR011711 GntR_C
IPR008920 TF_FadR/GntR_C
IPR000524 Tscrpt_reg_HTH_GntR
IPR023730 Tscrpt_reg_NanR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF07729 FCD, 1 hit
PF00392 GntR, 1 hit
PRINTSiPR00035 HTHGNTR
SMARTiView protein in SMART
SM00895 FCD, 1 hit
SM00345 HTH_GNTR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48008 SSF48008, 1 hit
PROSITEiView protein in PROSITE
PS50949 HTH_GNTR, 1 hit

Sequencei

Sequence statusi: Complete.

P0A8W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLMNAFDSQ TEDSSPAIGR NLRSRPLARK KLSEMVEEEL EQMIRRREFG
60 70 80 90 100
EGEQLPSERE LMAFFNVGRP SVREALAALK RKGLVQINNG ERARVSRPSA
110 120 130 140 150
DTIIGELSGM AKDFLSHPGG IAHFEQLRLF FESSLVRYAA EHATDEQIDL
160 170 180 190 200
LAKALEINSQ SLDNNAAFIR SDVDFHRVLA EIPGNPIFMA IHVALLDWLI
210 220 230 240 250
AARPTVTDQA LHEHNNVSYQ QHIAIVDAIR RHDPDEADRA LQSHLNSVSA
260
TWHAFGQTTN KKK
Length:263
Mass (Da):29,524
Last modified:June 7, 2005 - v1
Checksum:i306B3D8FAD7D8BB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58028.1
U00096 Genomic DNA Translation: AAC76258.1
AP009048 Genomic DNA Translation: BAE77269.1
PIRiD65114
RefSeqiNP_417693.3, NC_000913.3
WP_000523845.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76258; AAC76258; b3226
BAE77269; BAE77269; BAE77269
GeneIDi945468
KEGGiecj:JW3195
eco:b3226
PATRICifig|1411691.4.peg.3502

Similar proteinsi

Entry informationi

Entry nameiNANR_ECOLI
AccessioniPrimary (citable) accession number: P0A8W0
Secondary accession number(s): P45427, Q2M8Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health