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Protein

HTH-type transcriptional repressor NanR

Gene

nanR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids (PubMed:9864311, PubMed:12897000, PubMed:23935044). Represses expression of the nanATEK-yhcH, nanCMS and yjhBC operons. Acts by binding directly to the Nan box, a region of approximately 30 bp covering the promoter region (PubMed:23935044).3 Publications

Enzyme regulationi

N-acetylneuraminic acid (Neu5Ac) inactivates NanR by converting NanR oligomers to monomers.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi58 – 77H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7678-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor NanRUniRule annotationCurated
Gene namesi
Name:nanR1 PublicationUniRule annotation
Synonyms:yhcK
Ordered Locus Names:b3226, JW3195
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12817. nanR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506551 – 263HTH-type transcriptional repressor NanRAdd BLAST263

Proteomic databases

PaxDbiP0A8W0.
PRIDEiP0A8W0.

Interactioni

Subunit structurei

Homodimer (PubMed:12897000, PubMed:23935044). Might also form higher-order oligomers (PubMed:23935044).2 Publications

Protein-protein interaction databases

BioGridi4262443. 13 interactors.
DIPiDIP-12284N.
IntActiP0A8W0. 1 interactor.
STRINGi316385.ECDH10B_3403.

Structurei

3D structure databases

ProteinModelPortaliP0A8W0.
SMRiP0A8W0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 98HTH gntR-typeUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the NanR family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4108QBF. Bacteria.
COG2186. LUCA.
HOGENOMiHOG000273991.
InParanoidiP0A8W0.
PhylomeDBiP0A8W0.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
HAMAPiMF_01236. HTH_NanR. 1 hit.
InterProiView protein in InterPro
IPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR023730. Tscrpt_reg_NanR.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
PRINTSiPR00035. HTHGNTR.
SMARTiView protein in SMART
SM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiView protein in PROSITE
PS50949. HTH_GNTR. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A8W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLMNAFDSQ TEDSSPAIGR NLRSRPLARK KLSEMVEEEL EQMIRRREFG
60 70 80 90 100
EGEQLPSERE LMAFFNVGRP SVREALAALK RKGLVQINNG ERARVSRPSA
110 120 130 140 150
DTIIGELSGM AKDFLSHPGG IAHFEQLRLF FESSLVRYAA EHATDEQIDL
160 170 180 190 200
LAKALEINSQ SLDNNAAFIR SDVDFHRVLA EIPGNPIFMA IHVALLDWLI
210 220 230 240 250
AARPTVTDQA LHEHNNVSYQ QHIAIVDAIR RHDPDEADRA LQSHLNSVSA
260
TWHAFGQTTN KKK
Length:263
Mass (Da):29,524
Last modified:June 7, 2005 - v1
Checksum:i306B3D8FAD7D8BB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58028.1.
U00096 Genomic DNA. Translation: AAC76258.1.
AP009048 Genomic DNA. Translation: BAE77269.1.
PIRiD65114.
RefSeqiNP_417693.3. NC_000913.3.
WP_000523845.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76258; AAC76258; b3226.
BAE77269; BAE77269; BAE77269.
GeneIDi945468.
KEGGiecj:JW3195.
eco:b3226.
PATRICifig|1411691.4.peg.3502.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNANR_ECOLI
AccessioniPrimary (citable) accession number: P0A8W0
Secondary accession number(s): P45427, Q2M8Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: July 5, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families