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Protein

Protein Syd

Gene

syd

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.

GO - Biological processi

  • regulation of protein complex assembly Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7451-MONOMER.
ECOL316407:JW2764-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Syd
Gene namesi
Name:syd
Synonyms:ydr
Ordered Locus Names:b2793, JW2764
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12959. syd.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoCyc
  • extrinsic component of cytoplasmic side of plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Protein SydPRO_0000214136Add
BLAST

Proteomic databases

PaxDbiP0A8U0.
PRIDEiP0A8U0.

Interactioni

Protein-protein interaction databases

BioGridi4263497. 21 interactions.
DIPiDIP-48106N.
STRINGi511145.b2793.

Structurei

Secondary structure

1
181
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 2421Combined sources
Beta strandi25 – 273Combined sources
Beta strandi29 – 313Combined sources
Turni32 – 354Combined sources
Beta strandi41 – 444Combined sources
Beta strandi49 – 513Combined sources
Helixi63 – 686Combined sources
Helixi75 – 806Combined sources
Beta strandi82 – 854Combined sources
Beta strandi89 – 935Combined sources
Beta strandi96 – 1005Combined sources
Helixi106 – 12520Combined sources
Beta strandi131 – 1366Combined sources
Beta strandi142 – 1476Combined sources
Turni148 – 1503Combined sources
Beta strandi153 – 1575Combined sources
Beta strandi163 – 1697Combined sources
Helixi170 – 1767Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FFVX-ray2.00A/B1-181[»]
ProteinModelPortaliP0A8U0.
SMRiP0A8U0. Positions 1-181.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A8U0.

Family & Domainsi

Sequence similaritiesi

Belongs to the Syd family.Curated

Phylogenomic databases

eggNOGiENOG4108T6E. Bacteria.
ENOG4111WE9. LUCA.
HOGENOMiHOG000218409.
KOiK15723.
OMAiGIPSPCI.
OrthoDBiEOG67Q9B3.

Family and domain databases

HAMAPiMF_01104. Syd.
InterProiIPR009948. Syd.
[Graphical view]
PfamiPF07348. Syd. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A8U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLTAQALK DFTARYCDAW HEEHKSWPLS EELYGVPSPC IISTTEDAVY
60 70 80 90 100
WQPQPFTGEQ NVNAVERAFD IVIQPTIHTF YTTQFAGDMH AQFGDIKLTL
110 120 130 140 150
LQTWSEDDFR RVQENLIGHL VTQKRLKLPP TLFIATLEEE LEVISVCNLS
160 170 180
GEVCKETLGT RKRTHLASNL AEFLNQLKPL L
Length:181
Mass (Da):20,708
Last modified:June 7, 2005 - v1
Checksum:i95F6490B168DC222
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38520 Genomic DNA. Translation: BAA07525.1.
U29581 Genomic DNA. Translation: AAB40443.1.
U00096 Genomic DNA. Translation: AAC75835.1.
AP009048 Genomic DNA. Translation: BAE76865.1.
PIRiA55944.
RefSeqiNP_417273.1. NC_000913.3.
WP_000342431.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75835; AAC75835; b2793.
BAE76865; BAE76865; BAE76865.
GeneIDi947271.
KEGGiecj:JW2764.
eco:b2793.
PATRICi32121002. VBIEscCol129921_2893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38520 Genomic DNA. Translation: BAA07525.1.
U29581 Genomic DNA. Translation: AAB40443.1.
U00096 Genomic DNA. Translation: AAC75835.1.
AP009048 Genomic DNA. Translation: BAE76865.1.
PIRiA55944.
RefSeqiNP_417273.1. NC_000913.3.
WP_000342431.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FFVX-ray2.00A/B1-181[»]
ProteinModelPortaliP0A8U0.
SMRiP0A8U0. Positions 1-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263497. 21 interactions.
DIPiDIP-48106N.
STRINGi511145.b2793.

Proteomic databases

PaxDbiP0A8U0.
PRIDEiP0A8U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75835; AAC75835; b2793.
BAE76865; BAE76865; BAE76865.
GeneIDi947271.
KEGGiecj:JW2764.
eco:b2793.
PATRICi32121002. VBIEscCol129921_2893.

Organism-specific databases

EchoBASEiEB2792.
EcoGeneiEG12959. syd.

Phylogenomic databases

eggNOGiENOG4108T6E. Bacteria.
ENOG4111WE9. LUCA.
HOGENOMiHOG000218409.
KOiK15723.
OMAiGIPSPCI.
OrthoDBiEOG67Q9B3.

Enzyme and pathway databases

BioCyciEcoCyc:G7451-MONOMER.
ECOL316407:JW2764-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A8U0.
PROiP0A8U0.

Family and domain databases

HAMAPiMF_01104. Syd.
InterProiIPR009948. Syd.
[Graphical view]
PfamiPF07348. Syd. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Product of a new gene, syd, functionally interacts with SecY when overproduced in Escherichia coli."
    Shimoike T., Taura T., Kihara A., Yoshihisa T., Akiyama Y., Cannon K., Ito K.
    J. Biol. Chem. 270:5519-5526(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-16.
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Syd, a SecY-interacting protein, excludes SecA from the SecYE complex with an altered SecY24 subunit."
    Matsuo E., Mori H., Shimoike T., Ito K.
    J. Biol. Chem. 273:18835-18840(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SECY.
    Strain: K12.

Entry informationi

Entry nameiSYDP_ECOLI
AccessioniPrimary (citable) accession number: P0A8U0
Secondary accession number(s): P43526, Q2MA41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: January 20, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.