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Protein

Ribosomal protein L11 methyltransferase

Gene

prmA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Methylates ribosomal protein L11.

GO - Molecular functioni

  • protein-lysine N-methyltransferase activity Source: EcoCyc

GO - Biological processi

  • N-terminal peptidyl-alanine trimethylation Source: EcoCyc
  • peptidyl-lysine trimethylation Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Enzyme and pathway databases

BioCyciEcoCyc:EG11497-MONOMER.
ECOL316407:JW3227-MONOMER.
MetaCyc:EG11497-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein L11 methyltransferase (EC:2.1.1.-)
Short name:
L11 Mtase
Gene namesi
Name:prmA
Synonyms:yhdI
Ordered Locus Names:b3259, JW3227
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11497. prmA.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi285W → R: Great decrease in activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001922571 – 293Ribosomal protein L11 methyltransferaseAdd BLAST293

Proteomic databases

PaxDbiP0A8T1.
PRIDEiP0A8T1.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rplKP0A7J73EBI-556300,EBI-547288

Protein-protein interaction databases

BioGridi4261866. 4 interactors.
DIPiDIP-47862N.
IntActiP0A8T1. 14 interactors.
MINTiMINT-1232840.
STRINGi511145.b3259.

Structurei

3D structure databases

ProteinModelPortaliP0A8T1.
SMRiP0A8T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105F59. Bacteria.
COG2264. LUCA.
HOGENOMiHOG000007390.
InParanoidiP0A8T1.
KOiK02687.
OMAiFVHKIEQ.
PhylomeDBiP0A8T1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00735. Methyltr_PrmA. 1 hit.
InterProiIPR004498. Ribosomal_PrmA_MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PIRSFiPIRSF000401. RPL11_MTase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00406. prmA. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A8T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWIQLKLNT TGANAEDLSD ALMEAGAVSI TFQDTHDTPV FEPLPGETRL
60 70 80 90 100
WGDTDVIGLF DAETDMNDVV AILENHPLLG AGFAHKIEQL EDKDWEREWM
110 120 130 140 150
DNFHPMRFGE RLWICPSWRD VPDENAVNVM LDPGLAFGTG THPTTSLCLQ
160 170 180 190 200
WLDSLDLTGK TVIDFGCGSG ILAIAALKLG AAKAIGIDID PQAIQASRDN
210 220 230 240 250
AERNGVSDRL ELYLPKDQPE EMKADVVVAN ILAGPLRELA PLISVLPVSG
260 270 280 290
GLLGLSGILA SQAESVCEAY ADSFALDPVV EKEEWCRITG RKN
Length:293
Mass (Da):31,877
Last modified:June 7, 2005 - v1
Checksum:iCF0EDE130245B8FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78L → S in AAB28769 (PubMed:8226664).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67010 Genomic DNA. Translation: AAB28769.1.
U18997 Genomic DNA. Translation: AAA58062.1. Frameshift.
U18997 Genomic DNA. Translation: AAA58063.1. Frameshift.
U00096 Genomic DNA. Translation: AAC76291.1.
AP009048 Genomic DNA. Translation: BAE77300.1.
M30953 Genomic DNA. No translation available.
M95784 Genomic DNA. Translation: AAA23781.1.
PIRiE65118.
RefSeqiNP_417725.1. NC_000913.3.
WP_001145827.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76291; AAC76291; b3259.
BAE77300; BAE77300; BAE77300.
GeneIDi947708.
KEGGiecj:JW3227.
eco:b3259.
PATRICi32121948. VBIEscCol129921_3358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67010 Genomic DNA. Translation: AAB28769.1.
U18997 Genomic DNA. Translation: AAA58062.1. Frameshift.
U18997 Genomic DNA. Translation: AAA58063.1. Frameshift.
U00096 Genomic DNA. Translation: AAC76291.1.
AP009048 Genomic DNA. Translation: BAE77300.1.
M30953 Genomic DNA. No translation available.
M95784 Genomic DNA. Translation: AAA23781.1.
PIRiE65118.
RefSeqiNP_417725.1. NC_000913.3.
WP_001145827.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A8T1.
SMRiP0A8T1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261866. 4 interactors.
DIPiDIP-47862N.
IntActiP0A8T1. 14 interactors.
MINTiMINT-1232840.
STRINGi511145.b3259.

Proteomic databases

PaxDbiP0A8T1.
PRIDEiP0A8T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76291; AAC76291; b3259.
BAE77300; BAE77300; BAE77300.
GeneIDi947708.
KEGGiecj:JW3227.
eco:b3259.
PATRICi32121948. VBIEscCol129921_3358.

Organism-specific databases

EchoBASEiEB1460.
EcoGeneiEG11497. prmA.

Phylogenomic databases

eggNOGiENOG4105F59. Bacteria.
COG2264. LUCA.
HOGENOMiHOG000007390.
InParanoidiP0A8T1.
KOiK02687.
OMAiFVHKIEQ.
PhylomeDBiP0A8T1.

Enzyme and pathway databases

BioCyciEcoCyc:EG11497-MONOMER.
ECOL316407:JW3227-MONOMER.
MetaCyc:EG11497-MONOMER.

Miscellaneous databases

PROiP0A8T1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00735. Methyltr_PrmA. 1 hit.
InterProiIPR004498. Ribosomal_PrmA_MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PIRSFiPIRSF000401. RPL11_MTase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00406. prmA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPRMA_ECOLI
AccessioniPrimary (citable) accession number: P0A8T1
Secondary accession number(s): P28637
, P76680, P76681, Q2M8V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.