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Protein

Universal stress protein B

Gene

uspB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • response to ethanol Source: EcoCyc
  • response to stress Source: UniProtKB-HAMAP
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG12231-MONOMER.
ECOL316407:JW3461-MONOMER.

Protein family/group databases

TCDBi9.B.4.1.1. the universal stress protein-b (uspb) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Universal stress protein B
Gene namesi
Name:uspB
Synonyms:yhiO
Ordered Locus Names:b3494, JW3461
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12231. uspB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Topological domaini22 – 89CytoplasmicSequence analysisAdd BLAST68
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111PeriplasmicSequence analysis1

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells are sensitive to exposure to ethanol but not heat in stationary phase.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002120401 – 111Universal stress protein BAdd BLAST111

Proteomic databases

PaxDbiP0A8S5.
PRIDEiP0A8S5.

Expressioni

Inductioni

By growth arrest in general, by carbon, phosphate, and nitrogen starvation as well as osmotic shock and oxidative stress.

Interactioni

Protein-protein interaction databases

BioGridi4262095. 12 interactors.
STRINGi511145.b3494.

Structurei

3D structure databases

ProteinModelPortaliP0A8S5.
SMRiP0A8S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal stress protein B family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108V6B. Bacteria.
ENOG4111J5S. LUCA.
HOGENOMiHOG000218234.
KOiK06144.
OMAiGGFFTAH.

Family and domain databases

HAMAPiMF_01088. UspB. 1 hit.
InterProiIPR019598. Universal_stress_protein_B.
[Graphical view]
PfamiPF10625. UspB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A8S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISTVALFWA LCVVCIVNMA RYFSSLRALL VVLRNCDPLL YQYVDGGGFF
60 70 80 90 100
TSHGQPNKQV RLVWYIYAQR YRDHHDDEFI RRCERVRRQF ILTSALCGLV
110
VVSLIALMIW H
Length:111
Mass (Da):13,027
Last modified:June 7, 2005 - v1
Checksum:iBFD3813EDDD9CBFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18470.1.
U00096 Genomic DNA. Translation: AAC76519.1.
AP009048 Genomic DNA. Translation: BAE77800.1.
PIRiS47714.
RefSeqiNP_417951.1. NC_000913.3.
WP_000626187.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76519; AAC76519; b3494.
BAE77800; BAE77800; BAE77800.
GeneIDi948008.
KEGGiecj:JW3461.
eco:b3494.
PATRICi32122438. VBIEscCol129921_3596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18470.1.
U00096 Genomic DNA. Translation: AAC76519.1.
AP009048 Genomic DNA. Translation: BAE77800.1.
PIRiS47714.
RefSeqiNP_417951.1. NC_000913.3.
WP_000626187.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A8S5.
SMRiP0A8S5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262095. 12 interactors.
STRINGi511145.b3494.

Protein family/group databases

TCDBi9.B.4.1.1. the universal stress protein-b (uspb) family.

Proteomic databases

PaxDbiP0A8S5.
PRIDEiP0A8S5.

Protocols and materials databases

DNASUi948008.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76519; AAC76519; b3494.
BAE77800; BAE77800; BAE77800.
GeneIDi948008.
KEGGiecj:JW3461.
eco:b3494.
PATRICi32122438. VBIEscCol129921_3596.

Organism-specific databases

EchoBASEiEB2143.
EcoGeneiEG12231. uspB.

Phylogenomic databases

eggNOGiENOG4108V6B. Bacteria.
ENOG4111J5S. LUCA.
HOGENOMiHOG000218234.
KOiK06144.
OMAiGGFFTAH.

Enzyme and pathway databases

BioCyciEcoCyc:EG12231-MONOMER.
ECOL316407:JW3461-MONOMER.

Miscellaneous databases

PROiP0A8S5.

Family and domain databases

HAMAPiMF_01088. UspB. 1 hit.
InterProiIPR019598. Universal_stress_protein_B.
[Graphical view]
PfamiPF10625. UspB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUSPB_ECOLI
AccessioniPrimary (citable) accession number: P0A8S5
Secondary accession number(s): P37632, Q2M7F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression of uspB causes cell death in stationary phase.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.