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Protein

HTH-type transcriptional regulator HdfR

Gene

hdfR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.1 Publication

Miscellaneous

The expression of the hdfR gene is negatively regulated by H-NS.

Caution

Was originally thought to be involved in the expression of the phosphatidylserine synthetase pssA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi18 – 37H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG11449-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator HdfR
Alternative name(s):
H-NS-dependent flhDC regulator
Gene namesi
Name:hdfR
Synonyms:pssR, yifA, yifD
Ordered Locus Names:b4480, JW5607
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG11449 hdfR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056321 – 279HTH-type transcriptional regulator HdfRAdd BLAST279

Proteomic databases

PaxDbiP0A8R9
PRIDEiP0A8R9

Interactioni

Protein-protein interaction databases

BioGridi4261482, 6 interactors
DIPiDIP-48185N
IntActiP0A8R9, 5 interactors
STRINGi316385.ECDH10B_3951

Structurei

3D structure databases

ProteinModelPortaliP0A8R9
SMRiP0A8R9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58HTH lysR-typeAdd BLAST58

Phylogenomic databases

eggNOGiENOG4105CVI Bacteria
ENOG410XP94 LUCA
HOGENOMiHOG000275736
InParanoidiP0A8R9
OMAiESLMNTW
PhylomeDBiP0A8R9

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_01233 HTH_type_HdfR, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR020890 Tscrpt_reg_HTH_HdfR
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P0A8R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTELLKTFL EVSRTRHFGR AAESLYLTQS AVSFRIRQLE NQLGVNLFTR
60 70 80 90 100
HRNNIRLTAA GEKLLPYAET LMSTWQAARK EVAHTSRHNE FSIGASASLW
110 120 130 140 150
ECMLNQWLGR LYQNQDAHTG LQFEARIAQR QSLVKQLHER QLDLLITTEA
160 170 180 190 200
PKMDEFSSQL LGYFTLALYT SAPSKLKGDL NYLRLEWGPD FQQHEAGLIG
210 220 230 240 250
ADEVPILTTS SAELAQQQIA MLNGCTWLPV SWARKKGGLH TVVDSTTLSR
260 270
PLYAIWLQNS DKNALIRDLL KINVLDEVY
Length:279
Mass (Da):31,746
Last modified:June 7, 2005 - v1
Checksum:i450FF5A542BDE903
GO

Sequence cautioni

The sequence AAA24611 differs from that shown. Reason: Frameshift at positions 75, 79, 81 and 86.Curated
The sequence AAA67566 differs from that shown. Reason: Frameshift at position 81. Produces two separate ORFs.Curated
The sequence AAA67567 differs from that shown. Reason: Frameshift at position 81. Produces two separate ORFs.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37337 Genomic DNA Translation: AAA24611.1 Frameshift.
AF251030 Genomic DNA Translation: AAF97915.1
M87049 Genomic DNA Translation: AAA67567.1 Frameshift.
M87049 Genomic DNA Translation: AAA67566.1 Frameshift.
U00096 Genomic DNA Translation: AAT48206.1
AP009048 Genomic DNA Translation: BAE77532.1
PIRiE65179
RefSeqiWP_000379245.1, NZ_LN832404.1
YP_026246.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48206; AAT48206; b4480
BAE77532; BAE77532; BAE77532
GeneIDi2847698
KEGGiecj:JW5607
eco:b4480
PATRICifig|1411691.4.peg.2944

Entry informationi

Entry nameiHDFR_ECOLI
AccessioniPrimary (citable) accession number: P0A8R9
Secondary accession number(s): P22788
, P27826, Q2M874, Q9KHQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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