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Protein

HTH-type transcriptional regulator HdfR

Gene

hdfR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi18 – 37H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-HAMAP
  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11449-MONOMER.
ECOL316407:JW5607-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator HdfR
Alternative name(s):
H-NS-dependent flhDC regulator
Gene namesi
Name:hdfR
Synonyms:pssR, yifA, yifD
Ordered Locus Names:b4480, JW5607
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11449. hdfR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056321 – 279HTH-type transcriptional regulator HdfRAdd BLAST279

Proteomic databases

PaxDbiP0A8R9.
PRIDEiP0A8R9.

Interactioni

Protein-protein interaction databases

BioGridi4261482. 6 interactors.
DIPiDIP-48185N.
IntActiP0A8R9. 5 interactors.
STRINGi511145.b4480.

Structurei

3D structure databases

ProteinModelPortaliP0A8R9.
SMRiP0A8R9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58HTH lysR-typeAdd BLAST58

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CVI. Bacteria.
ENOG410XP94. LUCA.
HOGENOMiHOG000275736.
InParanoidiP0A8R9.
OMAiESLMNTW.
PhylomeDBiP0A8R9.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01233. HTH_type_HdfR. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR020890. Tscrpt_reg_HTH_HdfR.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A8R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTELLKTFL EVSRTRHFGR AAESLYLTQS AVSFRIRQLE NQLGVNLFTR
60 70 80 90 100
HRNNIRLTAA GEKLLPYAET LMSTWQAARK EVAHTSRHNE FSIGASASLW
110 120 130 140 150
ECMLNQWLGR LYQNQDAHTG LQFEARIAQR QSLVKQLHER QLDLLITTEA
160 170 180 190 200
PKMDEFSSQL LGYFTLALYT SAPSKLKGDL NYLRLEWGPD FQQHEAGLIG
210 220 230 240 250
ADEVPILTTS SAELAQQQIA MLNGCTWLPV SWARKKGGLH TVVDSTTLSR
260 270
PLYAIWLQNS DKNALIRDLL KINVLDEVY
Length:279
Mass (Da):31,746
Last modified:June 7, 2005 - v1
Checksum:i450FF5A542BDE903
GO

Sequence cautioni

The sequence AAA24611 differs from that shown. Reason: Frameshift at positions 75, 79, 81 and 86.Curated
The sequence AAA67566 differs from that shown. Reason: Frameshift at position 81. Produces two separate ORFs.Curated
The sequence AAA67567 differs from that shown. Reason: Frameshift at position 81. Produces two separate ORFs.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37337 Genomic DNA. Translation: AAA24611.1. Frameshift.
AF251030 Genomic DNA. Translation: AAF97915.1.
M87049 Genomic DNA. Translation: AAA67567.1. Frameshift.
M87049 Genomic DNA. Translation: AAA67566.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48206.1.
AP009048 Genomic DNA. Translation: BAE77532.1.
PIRiE65179.
RefSeqiWP_000379245.1. NZ_LN832404.1.
YP_026246.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48206; AAT48206; b4480.
BAE77532; BAE77532; BAE77532.
GeneIDi2847698.
KEGGiecj:JW5607.
eco:b4480.
PATRICi32123023. VBIEscCol129921_3881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37337 Genomic DNA. Translation: AAA24611.1. Frameshift.
AF251030 Genomic DNA. Translation: AAF97915.1.
M87049 Genomic DNA. Translation: AAA67567.1. Frameshift.
M87049 Genomic DNA. Translation: AAA67566.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48206.1.
AP009048 Genomic DNA. Translation: BAE77532.1.
PIRiE65179.
RefSeqiWP_000379245.1. NZ_LN832404.1.
YP_026246.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP0A8R9.
SMRiP0A8R9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261482. 6 interactors.
DIPiDIP-48185N.
IntActiP0A8R9. 5 interactors.
STRINGi511145.b4480.

Proteomic databases

PaxDbiP0A8R9.
PRIDEiP0A8R9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48206; AAT48206; b4480.
BAE77532; BAE77532; BAE77532.
GeneIDi2847698.
KEGGiecj:JW5607.
eco:b4480.
PATRICi32123023. VBIEscCol129921_3881.

Organism-specific databases

EchoBASEiEB1418.
EcoGeneiEG11449. hdfR.

Phylogenomic databases

eggNOGiENOG4105CVI. Bacteria.
ENOG410XP94. LUCA.
HOGENOMiHOG000275736.
InParanoidiP0A8R9.
OMAiESLMNTW.
PhylomeDBiP0A8R9.

Enzyme and pathway databases

BioCyciEcoCyc:EG11449-MONOMER.
ECOL316407:JW5607-MONOMER.

Miscellaneous databases

PROiP0A8R9.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01233. HTH_type_HdfR. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR020890. Tscrpt_reg_HTH_HdfR.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHDFR_ECOLI
AccessioniPrimary (citable) accession number: P0A8R9
Secondary accession number(s): P22788
, P27826, Q2M874, Q9KHQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The expression of the hdfR gene is negatively regulated by H-NS.

Caution

Was originally thought to be involved in the expression of the phosphatidylserine synthetase pssA.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.