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Protein

ATP-dependent Clp protease adapter protein ClpS

Gene

clpS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.UniRule annotation1 Publication

GO - Molecular functioni

  • chaperone binding Source: EcoCyc

GO - Biological processi

  • protein catabolic process Source: InterPro
  • proteolysis Source: UniProtKB-HAMAP
  • response to heat Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6463-MONOMER.
ECOL316407:JW0865-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease adapter protein ClpSUniRule annotation
Gene namesi
Name:clpSUniRule annotation
Synonyms:yljA
Ordered Locus Names:b0881, JW0865
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14241. clpS.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106ATP-dependent Clp protease adapter protein ClpSPRO_0000215707Add
BLAST

Proteomic databases

PaxDbiP0A8Q6.
PRIDEiP0A8Q6.

2D gel databases

SWISS-2DPAGEP0A8Q6.

Interactioni

Subunit structurei

Binds to the N-terminal domain of the chaperone ClpA.UniRule annotation2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
clpAP0ABH910EBI-561456,EBI-546140
dpsP0ABT25EBI-561456,EBI-549640

GO - Molecular functioni

  • chaperone binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4261321. 15 interactions.
852740. 1 interaction.
DIPiDIP-35408N.
IntActiP0A8Q6. 43 interactions.
MINTiMINT-365090.
STRINGi511145.b0881.

Structurei

Secondary structure

1
106
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 208Combined sources
Beta strandi28 – 336Combined sources
Beta strandi36 – 383Combined sources
Helixi40 – 5112Combined sources
Helixi55 – 6814Combined sources
Beta strandi69 – 768Combined sources
Helixi78 – 9417Combined sources
Beta strandi100 – 1056Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LZWX-ray2.50A1-106[»]
1MBUX-ray2.30C/D1-106[»]
1MBVX-ray3.30B1-106[»]
1MBXX-ray2.25C/D1-106[»]
1MG9X-ray2.30A1-106[»]
1R6OX-ray2.25C/D1-106[»]
1R6QX-ray2.35C/D1-106[»]
2W9RX-ray1.70A1-106[»]
2WA8X-ray2.15A/C1-106[»]
2WA9X-ray2.90A/B/C/D/E/F/G1-106[»]
3O1FX-ray1.40A/B26-106[»]
3O2BX-ray2.05A/C2-106[»]
3O2HX-ray1.70A2-106[»]
3O2OX-ray2.90A/B/C/D/E/F/G/H22-106[»]
ProteinModelPortaliP0A8Q6.
SMRiP0A8Q6. Positions 12-106.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A8Q6.

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KAE. Bacteria.
COG2127. LUCA.
HOGENOMiHOG000247049.
InParanoidiP0A8Q6.
KOiK06891.
OMAiRDWLDFD.
PhylomeDBiP0A8Q6.

Family and domain databases

Gene3Di3.30.1390.10. 1 hit.
HAMAPiMF_00302. ClpS. 1 hit.
InterProiIPR022935. ClpS.
IPR003769. ClpS_core.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
[Graphical view]
PfamiPF02617. ClpS. 1 hit.
[Graphical view]
SUPFAMiSSF54736. SSF54736. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A8Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTNDWLDF DQLAEEKVRD ALKPPSMYKV ILVNDDYTPM EFVIDVLQKF
60 70 80 90 100
FSYDVERATQ LMLAVHYQGK AICGVFTAEV AETKVAMVNK YARENEHPLL

CTLEKA
Length:106
Mass (Da):12,179
Last modified:June 7, 2005 - v1
Checksum:i2E9DC8000EA3CE86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73968.1.
AP009048 Genomic DNA. Translation: BAA35600.1.
PIRiA64827.
RefSeqiNP_415402.1. NC_000913.3.
WP_000520781.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73968; AAC73968; b0881.
BAA35600; BAA35600; BAA35600.
GeneIDi948443.
KEGGiecj:JW0865.
eco:b0881.
PATRICi32116971. VBIEscCol129921_0911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73968.1.
AP009048 Genomic DNA. Translation: BAA35600.1.
PIRiA64827.
RefSeqiNP_415402.1. NC_000913.3.
WP_000520781.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LZWX-ray2.50A1-106[»]
1MBUX-ray2.30C/D1-106[»]
1MBVX-ray3.30B1-106[»]
1MBXX-ray2.25C/D1-106[»]
1MG9X-ray2.30A1-106[»]
1R6OX-ray2.25C/D1-106[»]
1R6QX-ray2.35C/D1-106[»]
2W9RX-ray1.70A1-106[»]
2WA8X-ray2.15A/C1-106[»]
2WA9X-ray2.90A/B/C/D/E/F/G1-106[»]
3O1FX-ray1.40A/B26-106[»]
3O2BX-ray2.05A/C2-106[»]
3O2HX-ray1.70A2-106[»]
3O2OX-ray2.90A/B/C/D/E/F/G/H22-106[»]
ProteinModelPortaliP0A8Q6.
SMRiP0A8Q6. Positions 12-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261321. 15 interactions.
852740. 1 interaction.
DIPiDIP-35408N.
IntActiP0A8Q6. 43 interactions.
MINTiMINT-365090.
STRINGi511145.b0881.

2D gel databases

SWISS-2DPAGEP0A8Q6.

Proteomic databases

PaxDbiP0A8Q6.
PRIDEiP0A8Q6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73968; AAC73968; b0881.
BAA35600; BAA35600; BAA35600.
GeneIDi948443.
KEGGiecj:JW0865.
eco:b0881.
PATRICi32116971. VBIEscCol129921_0911.

Organism-specific databases

EchoBASEiEB3992.
EcoGeneiEG14241. clpS.

Phylogenomic databases

eggNOGiENOG4105KAE. Bacteria.
COG2127. LUCA.
HOGENOMiHOG000247049.
InParanoidiP0A8Q6.
KOiK06891.
OMAiRDWLDFD.
PhylomeDBiP0A8Q6.

Enzyme and pathway databases

BioCyciEcoCyc:G6463-MONOMER.
ECOL316407:JW0865-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A8Q6.
PROiP0A8Q6.

Family and domain databases

Gene3Di3.30.1390.10. 1 hit.
HAMAPiMF_00302. ClpS. 1 hit.
InterProiIPR022935. ClpS.
IPR003769. ClpS_core.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
[Graphical view]
PfamiPF02617. ClpS. 1 hit.
[Graphical view]
SUPFAMiSSF54736. SSF54736. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCLPS_ECOLI
AccessioniPrimary (citable) accession number: P0A8Q6
Secondary accession number(s): P75832
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.