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Protein

Fumarate reductase subunit C

Gene

frdC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.

GO - Molecular functioni

  • succinate dehydrogenase (ubiquinone) activity Source: EcoCyc
  • succinate dehydrogenase activity Source: EcoCyc

GO - Biological processi

  • anaerobic respiration Source: EcoCyc
  • bacterial-type flagellum assembly Source: EcoCyc
  • bacterial-type flagellum-dependent cell motility Source: EcoCyc
  • fermentation Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:FUM-MEMB1.
ECOL316407:JW4113-MONOMER.
MetaCyc:FUM-MEMB1.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate reductase subunit C
Alternative name(s):
Fumarate reductase 15 kDa hydrophobic protein
Gene namesi
Name:frdC
Ordered Locus Names:b4152, JW4113
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10332. frdC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121Cytoplasmic1 PublicationAdd
BLAST
Transmembranei22 – 4928HelicalAdd
BLAST
Topological domaini50 – 6516Periplasmic1 PublicationAdd
BLAST
Transmembranei66 – 9025HelicalAdd
BLAST
Topological domaini91 – 10414Cytoplasmic1 PublicationAdd
BLAST
Transmembranei105 – 12824HelicalAdd
BLAST
Topological domaini129 – 1313Periplasmic1 Publication

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
  • plasma membrane fumarate reductase complex Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Fumarate reductase subunit CPRO_0000196526Add
BLAST

Proteomic databases

PaxDbiP0A8Q0.

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).

Protein-protein interaction databases

BioGridi4262700. 357 interactions.
DIPiDIP-48082N.
IntActiP0A8Q0. 3 interactions.
MINTiMINT-1290104.
STRINGi511145.b4152.

Structurei

Secondary structure

1
131
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 183Combined sources
Helixi21 – 3111Combined sources
Helixi33 – 5119Combined sources
Helixi53 – 6412Combined sources
Helixi68 – 9023Combined sources
Helixi91 – 944Combined sources
Beta strandi98 – 1036Combined sources
Helixi107 – 12923Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KF6X-ray2.70C/O2-131[»]
1KFYX-ray3.60C/O2-131[»]
1L0VX-ray3.30C/O2-131[»]
2B76X-ray3.30C/O2-131[»]
3CIRX-ray3.65C/O2-131[»]
3P4PX-ray2.80C/O2-131[»]
3P4QX-ray3.35C/O2-131[»]
3P4RX-ray3.05C/O2-131[»]
3P4SX-ray3.10C/O2-131[»]
ProteinModelPortaliP0A8Q0.
SMRiP0A8Q0. Positions 2-131.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A8Q0.

Family & Domainsi

Sequence similaritiesi

Belongs to the FrdC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108WJH. Bacteria.
COG3029. LUCA.
HOGENOMiHOG000281484.
InParanoidiP0A8Q0.
KOiK00246.
OMAiMTATWWQ.
OrthoDBiEOG6NPM9V.

Family and domain databases

HAMAPiMF_00708. Fumarate_red_C.
InterProiIPR003510. Fumarate_red_C.
[Graphical view]
PfamiPF02300. Fumarate_red_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000180. FrdC. 1 hit.
ProDomiPD015900. Fumarate_red_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P0A8Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTKRKPYVR PMTSTWWKKL PFYRFYMLRE GTAVPAVWFS IELIFGLFAL
60 70 80 90 100
KNGPEAWAGF VDFLQNPVIV IINLITLAAA LLHTKTWFEL APKAANIIVK
110 120 130
DEKMGPEPII KSLWAVTVVA TIVILFVALY W
Length:131
Mass (Da):15,015
Last modified:July 21, 1986 - v1
Checksum:i26FDF83A2EF8EF43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01611 Genomic DNA. Translation: AAA23439.1.
V00277 Genomic DNA. Translation: CAA23535.1.
U14003 Genomic DNA. Translation: AAA97051.1.
U00096 Genomic DNA. Translation: AAC77112.1.
AP009048 Genomic DNA. Translation: BAE78156.1.
PIRiS56380.
RefSeqiNP_418576.1. NC_000913.3.
WP_000208757.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77112; AAC77112; b4152.
BAE78156; BAE78156; BAE78156.
GeneIDi948680.
KEGGiecj:JW4113.
eco:b4152.
PATRICi32123877. VBIEscCol129921_4286.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01611 Genomic DNA. Translation: AAA23439.1.
V00277 Genomic DNA. Translation: CAA23535.1.
U14003 Genomic DNA. Translation: AAA97051.1.
U00096 Genomic DNA. Translation: AAC77112.1.
AP009048 Genomic DNA. Translation: BAE78156.1.
PIRiS56380.
RefSeqiNP_418576.1. NC_000913.3.
WP_000208757.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KF6X-ray2.70C/O2-131[»]
1KFYX-ray3.60C/O2-131[»]
1L0VX-ray3.30C/O2-131[»]
2B76X-ray3.30C/O2-131[»]
3CIRX-ray3.65C/O2-131[»]
3P4PX-ray2.80C/O2-131[»]
3P4QX-ray3.35C/O2-131[»]
3P4RX-ray3.05C/O2-131[»]
3P4SX-ray3.10C/O2-131[»]
ProteinModelPortaliP0A8Q0.
SMRiP0A8Q0. Positions 2-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262700. 357 interactions.
DIPiDIP-48082N.
IntActiP0A8Q0. 3 interactions.
MINTiMINT-1290104.
STRINGi511145.b4152.

Proteomic databases

PaxDbiP0A8Q0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77112; AAC77112; b4152.
BAE78156; BAE78156; BAE78156.
GeneIDi948680.
KEGGiecj:JW4113.
eco:b4152.
PATRICi32123877. VBIEscCol129921_4286.

Organism-specific databases

EchoBASEiEB0328.
EcoGeneiEG10332. frdC.

Phylogenomic databases

eggNOGiENOG4108WJH. Bacteria.
COG3029. LUCA.
HOGENOMiHOG000281484.
InParanoidiP0A8Q0.
KOiK00246.
OMAiMTATWWQ.
OrthoDBiEOG6NPM9V.

Enzyme and pathway databases

BioCyciEcoCyc:FUM-MEMB1.
ECOL316407:JW4113-MONOMER.
MetaCyc:FUM-MEMB1.

Miscellaneous databases

EvolutionaryTraceiP0A8Q0.
PROiP0A8Q0.

Family and domain databases

HAMAPiMF_00708. Fumarate_red_C.
InterProiIPR003510. Fumarate_red_C.
[Graphical view]
PfamiPF02300. Fumarate_red_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000180. FrdC. 1 hit.
ProDomiPD015900. Fumarate_red_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Overlap between ampC and frd operons on the Escherichia coli chromosome."
    Grundstroem T., Jaurin B.
    Proc. Natl. Acad. Sci. U.S.A. 79:1111-1115(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
    Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Replacement of the proximal heme thiolate ligand in chloroperoxidase with a histidine residue."
    Yi X., Mroczko M., Manoj K.M., Wang X., Hager L.P.
    Proc. Natl. Acad. Sci. U.S.A. 96:12412-12417(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF CYS-50.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.
  7. "Structure of the Escherichia coli fumarate reductase respiratory complex."
    Iverson T.M., Luna-Chavez C., Cecchini G., Rees D.C.
    Science 284:1961-1966(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS).
  8. "Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site."
    Iverson T.M., Luna-Chavez C., Croal L.R., Cecchini G., Rees D.C.
    J. Biol. Chem. 277:16124-16130(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).

Entry informationi

Entry nameiFRDC_ECOLI
AccessioniPrimary (citable) accession number: P0A8Q0
Secondary accession number(s): P03805, Q2M6F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 20, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.