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Protein

Probable Fe(2+)-trafficking protein

Gene

yggX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. Necessary to maintain high levels of aconitase under oxidative stress.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:G7532-MONOMER.
ECOL316407:JW2929-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable Fe(2+)-trafficking protein
Gene namesi
Name:yggX
Ordered Locus Names:b2962, JW2929
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12984. yggX.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 9190Probable Fe(2+)-trafficking proteinPRO_0000214478Add
BLAST

Proteomic databases

EPDiP0A8P3.
PaxDbiP0A8P3.
PRIDEiP0A8P3.

2D gel databases

SWISS-2DPAGEP0A8P3.

Expressioni

Inductioni

By oxidative stress and SoxS.1 Publication

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

BioGridi4262360. 55 interactions.
IntActiP0A8P3. 3 interactions.
MINTiMINT-1253097.
STRINGi511145.b2962.

Structurei

Secondary structure

1
91
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 103Combined sources
Beta strandi12 – 143Combined sources
Helixi26 – 338Combined sources
Helixi36 – 5217Combined sources
Helixi60 – 7314Combined sources
Turni74 – 785Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YHDNMR-A2-91[»]
ProteinModelPortaliP0A8P3.
SMRiP0A8P3. Positions 2-91.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A8P3.

Family & Domainsi

Sequence similaritiesi

Belongs to the Fe(2+)-trafficking protein family.Curated

Phylogenomic databases

eggNOGiENOG4105KMG. Bacteria.
COG2924. LUCA.
HOGENOMiHOG000137239.
InParanoidiP0A8P3.
OMAiSKQTMLI.
PhylomeDBiP0A8P3.

Family and domain databases

HAMAPiMF_00686. Fe_traffic_YggX. 1 hit.
InterProiIPR007457. Fe_traffick_prot_YggX.
[Graphical view]
PfamiPF04362. Iron_traffic. 1 hit.
[Graphical view]
PIRSFiPIRSF029827. Fe_traffic_YggX. 1 hit.
ProDomiPD029191. Fe_traffick_prot_YggX. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF111148. SSF111148. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A8P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTIFCTFL QREAEGQDFQ LYPGELGKRI YNEISKEAWA QWQHKQTMLI
60 70 80 90
NEKKLNMMNA EHRKLLEQEM VNFLFEGKEV HIEGYTPEDK K
Length:91
Mass (Da):10,953
Last modified:January 23, 2007 - v2
Checksum:i1E3625B77C32B94B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69129.1.
U00096 Genomic DNA. Translation: AAC75999.1.
AP009048 Genomic DNA. Translation: BAE77025.1.
PIRiA65082.
RefSeqiNP_417437.1. NC_000913.3.
WP_000091700.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75999; AAC75999; b2962.
BAE77025; BAE77025; BAE77025.
GeneIDi947461.
KEGGiecj:JW2929.
eco:b2962.
PATRICi32121338. VBIEscCol129921_3057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69129.1.
U00096 Genomic DNA. Translation: AAC75999.1.
AP009048 Genomic DNA. Translation: BAE77025.1.
PIRiA65082.
RefSeqiNP_417437.1. NC_000913.3.
WP_000091700.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YHDNMR-A2-91[»]
ProteinModelPortaliP0A8P3.
SMRiP0A8P3. Positions 2-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262360. 55 interactions.
IntActiP0A8P3. 3 interactions.
MINTiMINT-1253097.
STRINGi511145.b2962.

2D gel databases

SWISS-2DPAGEP0A8P3.

Proteomic databases

EPDiP0A8P3.
PaxDbiP0A8P3.
PRIDEiP0A8P3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75999; AAC75999; b2962.
BAE77025; BAE77025; BAE77025.
GeneIDi947461.
KEGGiecj:JW2929.
eco:b2962.
PATRICi32121338. VBIEscCol129921_3057.

Organism-specific databases

EchoBASEiEB2809.
EcoGeneiEG12984. yggX.

Phylogenomic databases

eggNOGiENOG4105KMG. Bacteria.
COG2924. LUCA.
HOGENOMiHOG000137239.
InParanoidiP0A8P3.
OMAiSKQTMLI.
PhylomeDBiP0A8P3.

Enzyme and pathway databases

BioCyciEcoCyc:G7532-MONOMER.
ECOL316407:JW2929-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A8P3.
PROiP0A8P3.

Family and domain databases

HAMAPiMF_00686. Fe_traffic_YggX. 1 hit.
InterProiIPR007457. Fe_traffick_prot_YggX.
[Graphical view]
PfamiPF04362. Iron_traffic. 1 hit.
[Graphical view]
PIRSFiPIRSF029827. Fe_traffic_YggX. 1 hit.
ProDomiPD029191. Fe_traffick_prot_YggX. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF111148. SSF111148. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFETP_ECOLI
AccessioniPrimary (citable) accession number: P0A8P3
Secondary accession number(s): P52065, Q2M9N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.