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Protein

Probable Fe(2+)-trafficking protein

Gene

yggX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. Necessary to maintain high levels of aconitase under oxidative stress.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: EcoCyc

Keywordsi

Biological processStress response
LigandIron

Enzyme and pathway databases

BioCyciEcoCyc:G7532-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable Fe(2+)-trafficking protein
Gene namesi
Name:yggX
Ordered Locus Names:b2962, JW2929
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12984. yggX.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00002144782 – 91Probable Fe(2+)-trafficking proteinAdd BLAST90

Proteomic databases

EPDiP0A8P3.
PaxDbiP0A8P3.
PRIDEiP0A8P3.

2D gel databases

SWISS-2DPAGEiP0A8P3.

Expressioni

Inductioni

By oxidative stress and SoxS.1 Publication

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

BioGridi4262360. 55 interactors.
IntActiP0A8P3. 3 interactors.
MINTiMINT-1253097.
STRINGi316385.ECDH10B_3137.

Structurei

Secondary structure

191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 10Combined sources3
Beta strandi12 – 14Combined sources3
Helixi26 – 33Combined sources8
Helixi36 – 52Combined sources17
Helixi60 – 73Combined sources14
Turni74 – 78Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YHDNMR-A2-91[»]
ProteinModelPortaliP0A8P3.
SMRiP0A8P3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A8P3.

Family & Domainsi

Sequence similaritiesi

Belongs to the Fe(2+)-trafficking protein family.Curated

Phylogenomic databases

eggNOGiENOG4105KMG. Bacteria.
COG2924. LUCA.
HOGENOMiHOG000137239.
InParanoidiP0A8P3.
PhylomeDBiP0A8P3.

Family and domain databases

Gene3Di1.10.3880.10. 1 hit.
HAMAPiMF_00686. Fe_traffic_YggX. 1 hit.
InterProiView protein in InterPro
IPR007457. Fe_traffick_prot_YggX.
PfamiView protein in Pfam
PF04362. Iron_traffic. 1 hit.
PIRSFiPIRSF029827. Fe_traffic_YggX. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD029191. Fe_traffick_prot_YggX. 1 hit.
SUPFAMiSSF111148. SSF111148. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A8P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTIFCTFL QREAEGQDFQ LYPGELGKRI YNEISKEAWA QWQHKQTMLI
60 70 80 90
NEKKLNMMNA EHRKLLEQEM VNFLFEGKEV HIEGYTPEDK K
Length:91
Mass (Da):10,953
Last modified:January 23, 2007 - v2
Checksum:i1E3625B77C32B94B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69129.1.
U00096 Genomic DNA. Translation: AAC75999.1.
AP009048 Genomic DNA. Translation: BAE77025.1.
PIRiA65082.
RefSeqiNP_417437.1. NC_000913.3.
WP_000091700.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75999; AAC75999; b2962.
BAE77025; BAE77025; BAE77025.
GeneIDi947461.
KEGGiecj:JW2929.
eco:b2962.
PATRICifig|1411691.4.peg.3769.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFETP_ECOLI
AccessioniPrimary (citable) accession number: P0A8P3
Secondary accession number(s): P52065, Q2M9N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries