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Protein

Leucyl/phenylalanyl-tRNA--protein transferase

Gene

aat

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.By similarity

Catalytic activityi

L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = tRNA(Leu) + N-terminal L-leucyl-L-lysyl-[protein].
L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = tRNA(Leu) + N-terminal L-leucyl-L-arginyl-[protein].
L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferase (EC:2.3.2.6)
Alternative name(s):
L/F-transferase
Leucyltransferase
Phenyalanyltransferase
Gene namesi
Name:aat
Ordered Locus Names:SF0844, S0885
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002072441 – 234Leucyl/phenylalanyl-tRNA--protein transferaseAdd BLAST234

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0A8P2
SMRiP0A8P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L/F-transferase family.Curated

Phylogenomic databases

eggNOGiENOG4108R4Z Bacteria
COG2360 LUCA
HOGENOMiHOG000102325
KOiK00684
OMAiYRQGIFP

Family and domain databases

HAMAPiMF_00688 Leu_Phe_trans, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR004616 Leu/Phe-tRNA_Trfase
PANTHERiPTHR30098 PTHR30098, 1 hit
PfamiView protein in Pfam
PF03588 Leu_Phe_trans, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR00667 aat, 1 hit

Sequencei

Sequence statusi: Complete.

P0A8P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVQLSRHS IAFPSPEGAL REPNGLLALG GDLSPARLLM AYQRGIFPWF
60 70 80 90 100
SPGDPILWWS PDPRAVLWPE SLHISRSMKR FHKRSPYRVT MNYAFGQVIE
110 120 130 140 150
GCASDREEGT WITRGVVEAY HRLHELGHAH SIEVWREDEL VGGMYGVAQG
160 170 180 190 200
TLFCGESMFS RMENASKTAL LVFCEEFIGH GGKLIDCQVL NDHTASLGAC
210 220 230
EIPRRDYLNY LNQMRLGRLP NNFWVPRCLF SPQE
Length:234
Mass (Da):26,619
Last modified:June 7, 2005 - v1
Checksum:i8C725890D42ABF6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN42477.1
AE014073 Genomic DNA Translation: AAP16349.1
RefSeqiNP_706770.1, NC_004337.2
WP_001241678.1, NZ_NIYV01000018.1

Genome annotation databases

EnsemblBacteriaiAAN42477; AAN42477; SF0844
AAP16349; AAP16349; S0885
GeneIDi1023814
KEGGisfl:SF0844
sfx:S0885
PATRICifig|198214.7.peg.973

Similar proteinsi

Entry informationi

Entry nameiLFTR_SHIFL
AccessioniPrimary (citable) accession number: P0A8P2
Secondary accession number(s): P23885
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: April 25, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health