P0A8N7 (YJEA_ECOLI) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 63.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Uncharacterized protein YjeA Alternative name(s): GX | ||||||
| Gene names |
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| Organism | Escherichia coli (strain K12) | ||||||
| Taxonomic identifier | 83333 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 325 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | With YjeK might be involved in the post-translational modification of elongation factor P (EF-P). Ref.8 |
| Disruption phenotype | Cell have a reduced pyruvate oxidase activity and a reduced growth rate. Ref.6 |
| Sequence similarities | Belongs to the class-II aminoacyl-tRNA synthetase family. |
| Caution | Was originally (Ref.1) suggested to be a tRNA synthase, however its lack of an anticodon binding domain makes this highly unlikely. |
| Sequence caution | The sequence AAA97054.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. |
Ontologies
| Keywords | |
|---|---|
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | lysyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro lysine-tRNA ligase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Evidence for a new Escherichia coli protein resembling a lysyl-tRNA synthetase." Kong L., Fromant M., Blanquet S., Plateau P. Gene 108:163-164(1991) [PubMed: 1761227] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R. Nucleic Acids Res. 23:2105-2119(1995) [PubMed: 7610040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [3] | "The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [4] | "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [5] | "Nucleotide sequence coding for the flavoprotein subunit of the fumarate reductase of Escherichia coli." Cole S.T. Eur. J. Biochem. 122:479-484(1982) [PubMed: 7037404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-152. |
| [6] | "Mapping nonselectable genes of Escherichia coli by using transposon Tn10: location of a gene affecting pyruvate oxidase." Chang Y.-Y., Cronan J.E. Jr. J. Bacteriol. 151:1279-1289(1982) [PubMed: 6286595] [Abstract] Cited for: DISRUPTION PHENOTYPE. Strain: K12. |
| [7] | "Homology of aspartyl- and lysyl-tRNA synthetases." Gampel A., Tzagoloff A. Proc. Natl. Acad. Sci. U.S.A. 86:6023-6027(1989) [PubMed: 2668951] [Abstract] Cited for: SIMILARITY TO CLASS-II AA-TRNA SYNTHETASES. |
| [8] | "Predicting the pathway involved in post-translational modification of Elongation factor P in a subset of bacterial species." Bailly M., de Crecy-Lagard V. Biol. Direct 5:3-3(2010) [PubMed: 20070887] [Abstract] Cited for: POSSIBLE FUNCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X59988 Genomic DNA. Translation: CAA42604.1. U14003 Genomic DNA. Translation: AAA97054.1. Different initiation. U00096 Genomic DNA. Translation: AAC77115.2. AP009048 Genomic DNA. Translation: BAE78159.1. J01611 Genomic DNA. Translation: AAA23436.2. |
| PIR | S56383. |
| RefSeq | NP_418579.2. NC_000913.2. |
3D structure databases | |
| ProteinModelPortal | P0A8N7. |
| SMR | P0A8N7. Positions 5-325. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P0A8N7. 3 interactions. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000002581; EBESCP00000002581; EBESCG00000002105. EBESCT00000014713; EBESCP00000014004; EBESCG00000013774. |
| GeneID | 948672. |
| GenomeReviews | Gene locus JW4116 in contig AP009048_GR. Gene locus b4155 in contig U00096_GR. |
| KEGG | ecj:JW4116. eco:b4155. |
| PATRIC | 32123883. VBIEscCol129921_4289. |
Organism-specific databases | |
| EchoBASE | EB1196. |
| EcoGene | EG11211. poxA. |
Phylogenomic databases | |
| eggNOG | COG2269. |
| GeneTree | EBGT00050000009271. |
| HOGENOM | HBG631383. |
| OMA | MPEASGI. |
| PhylomeDB | P0A8N7. |
| ProtClustDB | PRK09350. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:EG11211-MONOMER. |
Gene expression databases | |
| Genevestigator | P0A8N7. |
Family and domain databases | |
| HAMAP | MF_00174. YjeA. [Tree] |
| InterPro | IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II. IPR004525. Lys-tRNA-synth-rel. IPR018149. Lys-tRNA-synth_II_C. [Graphical view] |
| KO | K04568. |
| PANTHER | PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF7. PTHR22594:SF7. 1 hit. |
| Pfam | PF00152. tRNA-synt_2. 1 hit. [Graphical view] |
| PRINTS | PR00982. TRNASYNTHLYS. |
| TIGRFAMs | TIGR00462. GenX. 1 hit. |
| PROSITE | PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | YJEA_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P0A8N7 Secondary accession number(s): P03812 Q8XDP9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| SIMILARITY comments Index of protein domains and families |

Clusters with