Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Macrodomain Ter protein

Gene

matP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.UniRule annotation1 Publication

GO - Molecular functioni

  • sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: EcoCyc
  • chromosome organization Source: EcoCyc
  • chromosome segregation Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12855-MONOMER.
ECOL316407:JW0939-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Macrodomain Ter proteinUniRule annotation
Gene namesi
Name:matPUniRule annotation
Synonyms:ycbG
Ordered Locus Names:b0956, JW0939
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12855. matP.

Subcellular locationi

  • Cytoplasm UniRule annotation1 Publication

  • Note: Accumulates in the cell as a discrete focus that colocalizes with the Ter macrodomain.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • DNA replication termination region Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mutants grown in rich medium show severe defects in chromosome segregation and cell division.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000703471 – 150Macrodomain Ter proteinAdd BLAST150

Proteomic databases

PaxDbiP0A8N0.
PRIDEiP0A8N0.

Expressioni

Gene expression databases

CollecTFiEXPREG_000007b0.

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi4260031. 9 interactors.
IntActiP0A8N0. 24 interactors.
STRINGi511145.b0956.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D8JX-ray3.55A/B/C/D/G/H/K/L1-150[»]
ProteinModelPortaliP0A8N0.
SMRiP0A8N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MatP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108R9Q. Bacteria.
COG3120. LUCA.
HOGENOMiHOG000218369.
KOiK09911.
OMAiMSTLKQD.

Family and domain databases

HAMAPiMF_01073. MatP. 1 hit.
InterProiIPR009390. MatP.
[Graphical view]
PfamiPF06303. MatP. 1 hit.
[Graphical view]
ProDomiPD033720. DUF1047. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P0A8N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYQQLENLE SGWKWKYLVK KHREGELITR YIEASAAQEA VDVLLSLENE
60 70 80 90 100
PVLVNGWIDK HMNPELVNRM KQTIRARRKR HFNAEHQHTR KKSIDLEFIV
110 120 130 140 150
WQRLAGLAQR RGKTLSETIV QLIEDAENKE KYANKMSSLK QDLQALLGKE
Length:150
Mass (Da):17,693
Last modified:June 7, 2005 - v1
Checksum:iB2E971E41317CF31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74042.1.
AP009048 Genomic DNA. Translation: BAA35714.1.
V00307 Genomic DNA. No translation available.
PIRiC64836.
RefSeqiNP_415476.1. NC_000913.3.
WP_000877161.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74042; AAC74042; b0956.
BAA35714; BAA35714; BAA35714.
GeneIDi945570.
KEGGiecj:JW0939.
eco:b0956.
PATRICi32117131. VBIEscCol129921_0990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74042.1.
AP009048 Genomic DNA. Translation: BAA35714.1.
V00307 Genomic DNA. No translation available.
PIRiC64836.
RefSeqiNP_415476.1. NC_000913.3.
WP_000877161.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D8JX-ray3.55A/B/C/D/G/H/K/L1-150[»]
ProteinModelPortaliP0A8N0.
SMRiP0A8N0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260031. 9 interactors.
IntActiP0A8N0. 24 interactors.
STRINGi511145.b0956.

Proteomic databases

PaxDbiP0A8N0.
PRIDEiP0A8N0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74042; AAC74042; b0956.
BAA35714; BAA35714; BAA35714.
GeneIDi945570.
KEGGiecj:JW0939.
eco:b0956.
PATRICi32117131. VBIEscCol129921_0990.

Organism-specific databases

EchoBASEiEB2699.
EcoGeneiEG12855. matP.

Phylogenomic databases

eggNOGiENOG4108R9Q. Bacteria.
COG3120. LUCA.
HOGENOMiHOG000218369.
KOiK09911.
OMAiMSTLKQD.

Enzyme and pathway databases

BioCyciEcoCyc:EG12855-MONOMER.
ECOL316407:JW0939-MONOMER.

Miscellaneous databases

PROiP0A8N0.

Gene expression databases

CollecTFiEXPREG_000007b0.

Family and domain databases

HAMAPiMF_01073. MatP. 1 hit.
InterProiIPR009390. MatP.
[Graphical view]
PfamiPF06303. MatP. 1 hit.
[Graphical view]
ProDomiPD033720. DUF1047. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiMATP_ECOLI
AccessioniPrimary (citable) accession number: P0A8N0
Secondary accession number(s): P45569, P75868, Q83RX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.