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Protein

UPF0761 membrane protein YihY

Gene

yihY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:EG11851-MONOMER.
ECOL316407:JW3857-MONOMER.

Protein family/group databases

TCDBi9.B.126.2.1. the putative lipid iv exporter (yhjd) family.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0761 membrane protein YihY
Gene namesi
Name:yihY
Ordered Locus Names:b3886, JW3857
ORF Names:b2268
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11851. yihY.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence analysisAdd
BLAST
Transmembranei39 – 6123HelicalSequence analysisAdd
BLAST
Topological domaini62 – 10039PeriplasmicSequence analysisAdd
BLAST
Transmembranei101 – 12020HelicalSequence analysisAdd
BLAST
Topological domaini121 – 14020CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 16323HelicalSequence analysisAdd
BLAST
Topological domaini164 – 18219PeriplasmicSequence analysisAdd
BLAST
Transmembranei183 – 20523HelicalSequence analysisAdd
BLAST
Topological domaini206 – 2116CytoplasmicSequence analysis
Transmembranei212 – 23423HelicalSequence analysisAdd
BLAST
Topological domaini235 – 2439PeriplasmicSequence analysis
Transmembranei244 – 26623HelicalSequence analysisAdd
BLAST
Topological domaini267 – 29024CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB-HAMAP
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290UPF0761 membrane protein YihYPRO_0000200981Add
BLAST

Proteomic databases

PaxDbiP0A8K8.
PRIDEiP0A8K8.

Interactioni

Protein-protein interaction databases

BioGridi4260958. 10 interactions.
STRINGi511145.b3886.

Structurei

3D structure databases

ProteinModelPortaliP0A8K8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0761 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107S2Z. Bacteria.
COG1295. LUCA.
HOGENOMiHOG000259417.
KOiK07058.
OMAiRWASELN.
OrthoDBiEOG63NMKT.
PhylomeDBiP0A8K8.

Family and domain databases

HAMAPiMF_00672. UPF0761.
InterProiIPR023679. UPF0761_bac.
IPR017039. Virul_fac_BrkB.
[Graphical view]
PfamiPF03631. Virul_fac_BrkB. 1 hit.
[Graphical view]
PIRSFiPIRSF035875. RNase_BN. 1 hit.
TIGRFAMsiTIGR00765. yihY_not_rbn. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A8K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKTIQDKAR HRTRPLWAWL KLLWQRIDED NMTTLAGNLA YVSLLSLVPL
60 70 80 90 100
VAVVFALFAA FPMFSDVSIQ LRHFIFANFL PATGDVIQRY IEQFVANSNK
110 120 130 140 150
MTAVGACGLI VTALLLMYSI DSALNTIWRS KRARPKIYSF AVYWMILTLG
160 170 180 190 200
PLLAGASLAI SSYLLSLRWA SDLNTVIDNV LRIFPLLLSW ISFWLLYSIV
210 220 230 240 250
PTIRVPNRDA IVGAFVAALL FEAGKKGFAL YITMFPSYQL IYGVLAVIPI
260 270 280 290
LFVWVYWTWC IVLLGAEITV TLGEYRKLKQ AAEQEEDDEP
Length:290
Mass (Da):32,839
Last modified:June 7, 2005 - v1
Checksum:iE027DAB37200CA93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03019.1.
U00096 Genomic DNA. Translation: AAD13448.1.
AP009048 Genomic DNA. Translation: BAE77423.1.
PIRiS40830.
RefSeqiNP_418322.1. NC_000913.3.
WP_000920762.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAD13448; AAD13448; b3886.
BAE77423; BAE77423; BAE77423.
GeneIDi948379.
KEGGiecj:JW3857.
eco:b3886.
PATRICi32123275. VBIEscCol129921_3998.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03019.1.
U00096 Genomic DNA. Translation: AAD13448.1.
AP009048 Genomic DNA. Translation: BAE77423.1.
PIRiS40830.
RefSeqiNP_418322.1. NC_000913.3.
WP_000920762.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A8K8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260958. 10 interactions.
STRINGi511145.b3886.

Protein family/group databases

TCDBi9.B.126.2.1. the putative lipid iv exporter (yhjd) family.

Proteomic databases

PaxDbiP0A8K8.
PRIDEiP0A8K8.

Protocols and materials databases

DNASUi948379.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD13448; AAD13448; b3886.
BAE77423; BAE77423; BAE77423.
GeneIDi948379.
KEGGiecj:JW3857.
eco:b3886.
PATRICi32123275. VBIEscCol129921_3998.

Organism-specific databases

EchoBASEiEB1797.
EcoGeneiEG11851. yihY.

Phylogenomic databases

eggNOGiENOG4107S2Z. Bacteria.
COG1295. LUCA.
HOGENOMiHOG000259417.
KOiK07058.
OMAiRWASELN.
OrthoDBiEOG63NMKT.
PhylomeDBiP0A8K8.

Enzyme and pathway databases

BioCyciEcoCyc:EG11851-MONOMER.
ECOL316407:JW3857-MONOMER.

Miscellaneous databases

PROiP0A8K8.

Family and domain databases

HAMAPiMF_00672. UPF0761.
InterProiIPR023679. UPF0761_bac.
IPR017039. Virul_fac_BrkB.
[Graphical view]
PfamiPF03631. Virul_fac_BrkB. 1 hit.
[Graphical view]
PIRSFiPIRSF035875. RNase_BN. 1 hit.
TIGRFAMsiTIGR00765. yihY_not_rbn. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the Escherichia coli rbn gene encoding the tRNA processing enzyme RNase BN."
    Callahan C., Deutscher M.P.
    J. Bacteriol. 178:7329-7332(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: B and K12 / CA265.
  2. "Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes."
    Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The RNase Z homologue encoded by Escherichia coli elaC gene is RNase BN."
    Ezraty B., Dahlgren B., Deutscher M.P.
    J. Biol. Chem. 280:16542-16545(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SHOWS THAT IT IS NOT RNASE BN.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYIHY_ECOLI
AccessioniPrimary (citable) accession number: P0A8K8
Secondary accession number(s): P32146, Q2M8I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: January 20, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally (PubMed:8955422) thought to be the tRNA-processing ribonuclease BN (rbn). This was later proven not to be the case (PubMed:15764599).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.