Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA gyrase inhibitor YacG

Gene

yacG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.UniRule annotation1 Publication

Cofactori

Zn2+Note: Binds 1 zinc ion.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Zinc1
Metal bindingi12Zinc1
Metal bindingi28Zinc1
Metal bindingi32Zinc1

GO - Molecular functioni

  • DNA topoisomerase (ATP-hydrolyzing) inhibitor activity Source: EcoCyc
  • zinc ion binding Source: EcoCyc

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG12314-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase inhibitor YacGUniRule annotation
Gene namesi
Name:yacGUniRule annotation
Ordered Locus Names:b0101, JW5008
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12314 yacG

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002116951 – 65DNA gyrase inhibitor YacGAdd BLAST65

Proteomic databases

PaxDbiP0A8H8
PRIDEiP0A8H8

Interactioni

Subunit structurei

Interacts with GyrB.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi4261884, 1 interactor
DIPiDIP-48126N
IntActiP0A8H8, 3 interactors
STRINGi316385.ECDH10B_0082

Structurei

Secondary structure

165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 8Combined sources3
Turni10 – 12Combined sources3
Beta strandi15 – 19Combined sources5
Turni23 – 26Combined sources4
Beta strandi27 – 29Combined sources3
Helixi30 – 41Combined sources12
Beta strandi49 – 51Combined sources3
Beta strandi54 – 56Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LV3NMR-A1-65[»]
4TMAX-ray3.30I/J/K/L1-65[»]
ProteinModelPortaliP0A8H8
SMRiP0A8H8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A8H8

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA gyrase inhibitor YacG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41067SF Bacteria
COG3024 LUCA
HOGENOMiHOG000255917
InParanoidiP0A8H8
KOiK09862
OMAiWAAEEHK
PhylomeDBiP0A8H8

Family and domain databases

Gene3Di3.30.50.10, 1 hit
HAMAPiMF_00649 DNA_gyrase_inhibitor_YacG, 1 hit
InterProiView protein in InterPro
IPR005584 DNA_gyrase_inhibitor_YacG
IPR013088 Znf_NHR/GATA
PANTHERiPTHR36150 PTHR36150, 1 hit
PfamiView protein in Pfam
PF03884 YacG, 1 hit

Sequencei

Sequence statusi: Complete.

P0A8H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETITVNCP TCGKTVVWGE ISPFRPFCSK RCQLIDLGEW AAEEKRIPSS
60
GDLSESDDWS EEPKQ
Length:65
Mass (Da):7,306
Last modified:June 7, 2005 - v1
Checksum:iF2747B62AFE6479D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73212.1
AP009048 Genomic DNA Translation: BAB96668.2
X04831 Genomic DNA No translation available.
PIRiE64732
RefSeqiNP_414643.1, NC_000913.3
WP_000005042.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73212; AAC73212; b0101
BAB96668; BAB96668; BAB96668
GeneIDi945630
KEGGiecj:JW5008
eco:b0101
PATRICifig|1411691.4.peg.2180

Similar proteinsi

Entry informationi

Entry nameiYACG_ECOLI
AccessioniPrimary (citable) accession number: P0A8H8
Secondary accession number(s): P36681, P75644, Q8KJQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health