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Protein

Zinc transporter ZupT

Gene

zupT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions.1 Publication

GO - Molecular functioni

  • cadmium ion transmembrane transporter activity Source: EcoCyc
  • cobalt ion transmembrane transporter activity Source: EcoCyc
  • copper uptake transmembrane transporter activity Source: EcoCyc
  • ferrous iron transmembrane transporter activity Source: EcoCyc
  • manganese ion transmembrane transporter activity Source: EcoCyc
  • zinc ion transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • cadmium ion transmembrane transport Source: EcoCyc
  • zinc II ion transmembrane transport Source: GO_Central
  • zinc II ion transport Source: CACAO
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG11167-MONOMER.
ECOL316407:JW3008-MONOMER.
MetaCyc:EG11167-MONOMER.

Protein family/group databases

TCDBi2.A.5.5.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZupT
Gene namesi
Name:zupT
Synonyms:ygiE
Ordered Locus Names:b3040, JW3008
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11167. zupT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence analysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence analysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Zinc transporter ZupTPRO_0000207271Add
BLAST

Proteomic databases

PaxDbiP0A8H3.

Interactioni

Protein-protein interaction databases

STRINGi511145.b3040.

Structurei

3D structure databases

ProteinModelPortaliP0A8H3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DUN. Bacteria.
COG0428. LUCA.
HOGENOMiHOG000232704.
InParanoidiP0A8H3.
KOiK07238.
OMAiMIVASFT.
PhylomeDBiP0A8H3.

Family and domain databases

HAMAPiMF_00548. ZupT. 1 hit.
InterProiIPR003689. ZIP.
IPR023498. Zn_transptr_ZupT.
[Graphical view]
PfamiPF02535. Zip. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A8H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPLILTIL AGAATFIGAF LGVLGQKPSN RLLAFSLGFA AGIMLLISLM
60 70 80 90 100
EMLPAALAAE GMSPVLGYGM FIFGLLGYFG LDRMLPHAHP QDLMQKSVQP
110 120 130 140 150
LPKSIKRTAI LLTLGISLHN FPEGIATFVT ASSNLELGFG IALAVALHNI
160 170 180 190 200
PEGLAVAGPV YAATGSKRTA ILWAGISGLA EILGGVLAWL ILGSMISPVV
210 220 230 240 250
MAAIMAAVAG IMVALSVDEL MPLAKEIDPN NNPSYGVLCG MSVMGFSLVL

LQTAGIG
Length:257
Mass (Da):26,485
Last modified:June 7, 2005 - v1
Checksum:i1E5E5B007F62FAA9
GO

Sequence cautioni

The sequence AAA69208 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77129 Genomic DNA. Translation: AAA71878.1.
U28377 Genomic DNA. Translation: AAA69208.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76076.1.
AP009048 Genomic DNA. Translation: BAE77096.1.
PIRiS22363.
RefSeqiNP_417512.1. NC_000913.3.
WP_001295627.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76076; AAC76076; b3040.
BAE77096; BAE77096; BAE77096.
GeneIDi947035.
KEGGiecj:JW3008.
eco:b3040.
PATRICi32121490. VBIEscCol129921_3132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77129 Genomic DNA. Translation: AAA71878.1.
U28377 Genomic DNA. Translation: AAA69208.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76076.1.
AP009048 Genomic DNA. Translation: BAE77096.1.
PIRiS22363.
RefSeqiNP_417512.1. NC_000913.3.
WP_001295627.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A8H3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b3040.

Protein family/group databases

TCDBi2.A.5.5.1. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Proteomic databases

PaxDbiP0A8H3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76076; AAC76076; b3040.
BAE77096; BAE77096; BAE77096.
GeneIDi947035.
KEGGiecj:JW3008.
eco:b3040.
PATRICi32121490. VBIEscCol129921_3132.

Organism-specific databases

EchoBASEiEB1155.
EcoGeneiEG11167. zupT.

Phylogenomic databases

eggNOGiENOG4105DUN. Bacteria.
COG0428. LUCA.
HOGENOMiHOG000232704.
InParanoidiP0A8H3.
KOiK07238.
OMAiMIVASFT.
PhylomeDBiP0A8H3.

Enzyme and pathway databases

BioCyciEcoCyc:EG11167-MONOMER.
ECOL316407:JW3008-MONOMER.
MetaCyc:EG11167-MONOMER.

Miscellaneous databases

PROiP0A8H3.

Family and domain databases

HAMAPiMF_00548. ZupT. 1 hit.
InterProiIPR003689. ZIP.
IPR023498. Zn_transptr_ZupT.
[Graphical view]
PfamiPF02535. Zip. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZUPT_ECOLI
AccessioniPrimary (citable) accession number: P0A8H3
Secondary accession number(s): P24198, Q2M9G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.