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Protein

Exodeoxyribonuclease 7 small subunit

Gene

xseB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. It can also degrade 3' or 5' ss regions extending from the termini of duplex DNA molecules and displaced ss regions.

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.

GO - Molecular functioni

  • exodeoxyribonuclease VII activity Source: EcoliWiki

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciEcoCyc:EG11098-MONOMER.
ECOL316407:JW0412-MONOMER.
MetaCyc:EG11098-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 small subunit (EC:3.1.11.6)
Alternative name(s):
Exodeoxyribonuclease VII small subunit
Short name:
Exonuclease VII small subunit
Gene namesi
Name:xseB
Synonyms:yajE
Ordered Locus Names:b0422, JW0412
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11098. xseB.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • exodeoxyribonuclease VII complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 8079Exodeoxyribonuclease 7 small subunitPRO_0000206945Add
BLAST

Proteomic databases

PaxDbiP0A8G9.
PRIDEiP0A8G9.

Interactioni

Subunit structurei

Heterooligomer composed of two different subunits with an approximate ratio of 4 small subunits for 1 large.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
yebVP645034EBI-1116872,EBI-9126792

Protein-protein interaction databases

BioGridi4259844. 55 interactions.
DIPiDIP-48031N.
IntActiP0A8G9. 4 interactions.
STRINGi511145.b0422.

Structurei

3D structure databases

ProteinModelPortaliP0A8G9.
SMRiP0A8G9. Positions 8-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XseB family.Curated

Phylogenomic databases

eggNOGiENOG41067QG. Bacteria.
COG1722. LUCA.
HOGENOMiHOG000228798.
InParanoidiP0A8G9.
KOiK03602.
OMAiAPLNDYK.
PhylomeDBiP0A8G9.

Family and domain databases

Gene3Di1.10.287.1040. 1 hit.
HAMAPiMF_00337. Exonuc_7_S. 1 hit.
InterProiIPR003761. Exonuc_VII_S.
[Graphical view]
PfamiPF02609. Exonuc_VII_S. 1 hit.
[Graphical view]
PIRSFiPIRSF006488. Exonuc_VII_S. 1 hit.
ProDomiPD028235. Exonuc_VII_S. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01280. xseB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A8G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKNEAPAS FEKALSELEQ IVTRLESGDL PLEEALNEFE RGVQLARQGQ
60 70 80
AKLQQAEQRV QILLSDNEDA SLTPFTPDNE
Length:80
Mass (Da):8,952
Last modified:January 23, 2007 - v2
Checksum:i8B10380D442CADF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00694 Genomic DNA. Translation: BAA00598.1.
U82664 Genomic DNA. Translation: AAB40178.1.
U00096 Genomic DNA. Translation: AAC73525.1.
AP009048 Genomic DNA. Translation: BAE76202.1.
PIRiJQ0664.
RefSeqiNP_414956.1. NC_000913.3.
WP_001124935.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73525; AAC73525; b0422.
BAE76202; BAE76202; BAE76202.
GeneIDi945069.
KEGGiecj:JW0412.
eco:b0422.
PATRICi32115993. VBIEscCol129921_0438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00694 Genomic DNA. Translation: BAA00598.1.
U82664 Genomic DNA. Translation: AAB40178.1.
U00096 Genomic DNA. Translation: AAC73525.1.
AP009048 Genomic DNA. Translation: BAE76202.1.
PIRiJQ0664.
RefSeqiNP_414956.1. NC_000913.3.
WP_001124935.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A8G9.
SMRiP0A8G9. Positions 8-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259844. 55 interactions.
DIPiDIP-48031N.
IntActiP0A8G9. 4 interactions.
STRINGi511145.b0422.

Proteomic databases

PaxDbiP0A8G9.
PRIDEiP0A8G9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73525; AAC73525; b0422.
BAE76202; BAE76202; BAE76202.
GeneIDi945069.
KEGGiecj:JW0412.
eco:b0422.
PATRICi32115993. VBIEscCol129921_0438.

Organism-specific databases

EchoBASEiEB1090.
EcoGeneiEG11098. xseB.

Phylogenomic databases

eggNOGiENOG41067QG. Bacteria.
COG1722. LUCA.
HOGENOMiHOG000228798.
InParanoidiP0A8G9.
KOiK03602.
OMAiAPLNDYK.
PhylomeDBiP0A8G9.

Enzyme and pathway databases

BioCyciEcoCyc:EG11098-MONOMER.
ECOL316407:JW0412-MONOMER.
MetaCyc:EG11098-MONOMER.

Miscellaneous databases

PROiP0A8G9.

Family and domain databases

Gene3Di1.10.287.1040. 1 hit.
HAMAPiMF_00337. Exonuc_7_S. 1 hit.
InterProiIPR003761. Exonuc_VII_S.
[Graphical view]
PfamiPF02609. Exonuc_VII_S. 1 hit.
[Graphical view]
PIRSFiPIRSF006488. Exonuc_VII_S. 1 hit.
ProDomiPD028235. Exonuc_VII_S. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01280. xseB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEX7S_ECOLI
AccessioniPrimary (citable) accession number: P0A8G9
Secondary accession number(s): P22938, Q2MC04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.