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Protein

Uronate isomerase

Gene

uxaC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucuronate = D-fructuronate.
D-galacturonate = D-tagaturonate.

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

  • D-galacturonate catabolic process Source: EcoCyc
  • D-glucuronate catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciEcoCyc:UXAC-MONOMER.
ECOL316407:JW3063-MONOMER.
MetaCyc:UXAC-MONOMER.
BRENDAi5.3.1.12. 2026.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Uronate isomerase (EC:5.3.1.12)
Alternative name(s):
Glucuronate isomerase
Uronic isomerase
Gene namesi
Name:uxaC
Synonyms:ygjX, ygjY, ygjZ
Ordered Locus Names:b3092, JW3063
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12737. uxaC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Uronate isomerasePRO_0000172771Add
BLAST

Proteomic databases

EPDiP0A8G3.
PaxDbiP0A8G3.
PRIDEiP0A8G3.

Expressioni

Inductioni

Repressed by LeuO and H-NS. Part of the uxaCA operon.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262408. 17 interactions.
IntActiP0A8G3. 9 interactions.
STRINGi511145.b3092.

Structurei

3D structure databases

ProteinModelPortaliP0A8G3.
SMRiP0A8G3. Positions 4-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uronate isomerase family.Curated

Phylogenomic databases

eggNOGiENOG4105D2H. Bacteria.
COG1904. LUCA.
InParanoidiP0A8G3.
KOiK01812.
OMAiREMTTET.
PhylomeDBiP0A8G3.

Family and domain databases

Gene3Di1.10.2020.10. 1 hit.
HAMAPiMF_00675. UxaC. 1 hit.
InterProiIPR032466. Metal_Hydrolase.
IPR003766. Uronate_isomerase.
IPR023177. Uronate_isomerase_dom2.
[Graphical view]
PfamiPF02614. UxaC. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A8G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPFMTEDFL LDTEFARRLY HDYAKDQPIF DYHCHLPPQQ IAEDYRFKNL
60 70 80 90 100
YDIWLKGDHY KWRAMRTNGV AERLCTGDAS DREKFDAWAA TVPHTIGNPL
110 120 130 140 150
YHWTHLELRR PFGITGKLLS PSTADEIWNE CNELLAQDNF SARGIMQQMN
160 170 180 190 200
VKMVGTTDDP IDSLEHHAEI AKDGSFTIKV LPSWRPDKAF NIEQATFNDY
210 220 230 240 250
MAKLGEVSDT DIRRFADLQT ALTKRLDHFA AHGCKVSDHA LDVVMFAEAN
260 270 280 290 300
EAELDSILAR RLAGETLSEH EVAQFKTAVL VFLGAEYARR GWVQQYHIGA
310 320 330 340 350
LRNNNLRQFK LLGPDVGFDS INDRPMAEEL SKLLSKQNEE NLLPKTILYC
360 370 380 390 400
LNPRDNEVLG TMIGNFQGEG MPGKMQFGSG WWFNDQKDGM ERQMTQLAQL
410 420 430 440 450
GLLSRFVGML TDSRSFLSYT RHEYFRRILC QMIGRWVEAG EAPADINLLG
460 470
EMVKNICFNN ARDYFAIELN
Length:470
Mass (Da):53,987
Last modified:June 7, 2005 - v1
Checksum:i9E51AA7B88411281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13328 Genomic DNA. Translation: BAA02587.1.
U18997 Genomic DNA. Translation: AAA57896.1. Frameshift.
U18997 Genomic DNA. Translation: AAA57895.1. Frameshift.
U18997 Genomic DNA. Translation: AAA57894.1. Frameshift.
U00096 Genomic DNA. Translation: AAC76127.1.
AP009048 Genomic DNA. Translation: BAE77142.1.
PIRiA65098.
RefSeqiNP_417563.1. NC_000913.3.
WP_000187442.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76127; AAC76127; b3092.
BAE77142; BAE77142; BAE77142.
GeneIDi947599.
KEGGiecj:JW3063.
eco:b3092.
PATRICi32121602. VBIEscCol129921_3187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13328 Genomic DNA. Translation: BAA02587.1.
U18997 Genomic DNA. Translation: AAA57896.1. Frameshift.
U18997 Genomic DNA. Translation: AAA57895.1. Frameshift.
U18997 Genomic DNA. Translation: AAA57894.1. Frameshift.
U00096 Genomic DNA. Translation: AAC76127.1.
AP009048 Genomic DNA. Translation: BAE77142.1.
PIRiA65098.
RefSeqiNP_417563.1. NC_000913.3.
WP_000187442.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A8G3.
SMRiP0A8G3. Positions 4-468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262408. 17 interactions.
IntActiP0A8G3. 9 interactions.
STRINGi511145.b3092.

Proteomic databases

EPDiP0A8G3.
PaxDbiP0A8G3.
PRIDEiP0A8G3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76127; AAC76127; b3092.
BAE77142; BAE77142; BAE77142.
GeneIDi947599.
KEGGiecj:JW3063.
eco:b3092.
PATRICi32121602. VBIEscCol129921_3187.

Organism-specific databases

EchoBASEiEB2593.
EcoGeneiEG12737. uxaC.

Phylogenomic databases

eggNOGiENOG4105D2H. Bacteria.
COG1904. LUCA.
InParanoidiP0A8G3.
KOiK01812.
OMAiREMTTET.
PhylomeDBiP0A8G3.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciEcoCyc:UXAC-MONOMER.
ECOL316407:JW3063-MONOMER.
MetaCyc:UXAC-MONOMER.
BRENDAi5.3.1.12. 2026.

Miscellaneous databases

PROiP0A8G3.

Family and domain databases

Gene3Di1.10.2020.10. 1 hit.
HAMAPiMF_00675. UxaC. 1 hit.
InterProiIPR032466. Metal_Hydrolase.
IPR003766. Uronate_isomerase.
IPR023177. Uronate_isomerase_dom2.
[Graphical view]
PfamiPF02614. UxaC. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUXAC_ECOLI
AccessioniPrimary (citable) accession number: P0A8G3
Secondary accession number(s): P42605
, P42606, P42607, P76662, P76663, P76664, Q2M9B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.