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Protein

Uronate isomerase

Gene

uxaC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucuronate = D-fructuronate.
D-galacturonate = D-tagaturonate.

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

  • D-galacturonate catabolic process Source: EcoCyc
  • D-glucuronate catabolic process Source: EcoCyc

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BioCyciEcoCyc:UXAC-MONOMER
MetaCyc:UXAC-MONOMER
BRENDAi5.3.1.12 2026
UniPathwayiUPA00246

Names & Taxonomyi

Protein namesi
Recommended name:
Uronate isomerase (EC:5.3.1.12)
Alternative name(s):
Glucuronate isomerase
Uronic isomerase
Gene namesi
Name:uxaC
Synonyms:ygjX, ygjY, ygjZ
Ordered Locus Names:b3092, JW3063
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12737 uxaC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001727711 – 470Uronate isomeraseAdd BLAST470

Proteomic databases

EPDiP0A8G3
PaxDbiP0A8G3
PRIDEiP0A8G3

Expressioni

Inductioni

Repressed by LeuO and H-NS. Part of the uxaCA operon.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262408, 28 interactors
IntActiP0A8G3, 9 interactors
STRINGi316385.ECDH10B_3268

Structurei

3D structure databases

ProteinModelPortaliP0A8G3
SMRiP0A8G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D2H Bacteria
COG1904 LUCA
InParanoidiP0A8G3
KOiK01812
OMAiFREMTTE
PhylomeDBiP0A8G3

Family and domain databases

HAMAPiMF_00675 UxaC, 1 hit
InterProiView protein in InterPro
IPR032466 Metal_Hydrolase
IPR003766 Uronate_isomerase
PfamiView protein in Pfam
PF02614 UxaC, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit

Sequencei

Sequence statusi: Complete.

P0A8G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPFMTEDFL LDTEFARRLY HDYAKDQPIF DYHCHLPPQQ IAEDYRFKNL
60 70 80 90 100
YDIWLKGDHY KWRAMRTNGV AERLCTGDAS DREKFDAWAA TVPHTIGNPL
110 120 130 140 150
YHWTHLELRR PFGITGKLLS PSTADEIWNE CNELLAQDNF SARGIMQQMN
160 170 180 190 200
VKMVGTTDDP IDSLEHHAEI AKDGSFTIKV LPSWRPDKAF NIEQATFNDY
210 220 230 240 250
MAKLGEVSDT DIRRFADLQT ALTKRLDHFA AHGCKVSDHA LDVVMFAEAN
260 270 280 290 300
EAELDSILAR RLAGETLSEH EVAQFKTAVL VFLGAEYARR GWVQQYHIGA
310 320 330 340 350
LRNNNLRQFK LLGPDVGFDS INDRPMAEEL SKLLSKQNEE NLLPKTILYC
360 370 380 390 400
LNPRDNEVLG TMIGNFQGEG MPGKMQFGSG WWFNDQKDGM ERQMTQLAQL
410 420 430 440 450
GLLSRFVGML TDSRSFLSYT RHEYFRRILC QMIGRWVEAG EAPADINLLG
460 470
EMVKNICFNN ARDYFAIELN
Length:470
Mass (Da):53,987
Last modified:June 7, 2005 - v1
Checksum:i9E51AA7B88411281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13328 Genomic DNA Translation: BAA02587.1
U18997 Genomic DNA Translation: AAA57896.1 Frameshift.
U18997 Genomic DNA Translation: AAA57895.1 Frameshift.
U18997 Genomic DNA Translation: AAA57894.1 Frameshift.
U00096 Genomic DNA Translation: AAC76127.1
AP009048 Genomic DNA Translation: BAE77142.1
PIRiA65098
RefSeqiNP_417563.1, NC_000913.3
WP_000187442.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76127; AAC76127; b3092
BAE77142; BAE77142; BAE77142
GeneIDi947599
KEGGiecj:JW3063
eco:b3092
PATRICifig|511145.12.peg.3187

Similar proteinsi

Entry informationi

Entry nameiUXAC_ECOLI
AccessioniPrimary (citable) accession number: P0A8G3
Secondary accession number(s): P42605
, P42606, P42607, P76662, P76663, P76664, Q2M9B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health