P0A8G3 (UXAC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uronate isomerase
EC=5.3.1.12

Alternative name(s):
Glucuronate isomerase
Uronic isomerase

Gene names

Name:	uxaC
Synonyms:	ygjX, ygjY, ygjZ
Ordered Locus Names:	b3092, JW3063

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-glucuronate = D-fructuronate. HAMAP-Rule MF_00675 D-galacturonate = D-tagaturonate. HAMAP-Rule MF_00675
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00675
Induction	Repressed by LeuO and H-NS. Part of the uxaCA operon. Ref.4
Sequence similarities	Belongs to the uronate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-galacturonate catabolic process Inferred from mutant phenotype PubMed 6450743. Source: EcoCyc D-glucuronate catabolic process Inferred from direct assay PubMed 4594308. Source: EcoCyc
Molecular_function	glucuronate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Uronate isomerase HAMAP-Rule MF_00675		PRO_0000172771

Sequences

	Sequence		Length	Mass (Da)
	P0A8G3 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: 9E51AA7B88411281	FASTA	470	53,987
	10 20 30 40 50 60 MTPFMTEDFL LDTEFARRLY HDYAKDQPIF DYHCHLPPQQ IAEDYRFKNL YDIWLKGDHY 70 80 90 100 110 120 KWRAMRTNGV AERLCTGDAS DREKFDAWAA TVPHTIGNPL YHWTHLELRR PFGITGKLLS 130 140 150 160 170 180 PSTADEIWNE CNELLAQDNF SARGIMQQMN VKMVGTTDDP IDSLEHHAEI AKDGSFTIKV 190 200 210 220 230 240 LPSWRPDKAF NIEQATFNDY MAKLGEVSDT DIRRFADLQT ALTKRLDHFA AHGCKVSDHA 250 260 270 280 290 300 LDVVMFAEAN EAELDSILAR RLAGETLSEH EVAQFKTAVL VFLGAEYARR GWVQQYHIGA 310 320 330 340 350 360 LRNNNLRQFK LLGPDVGFDS INDRPMAEEL SKLLSKQNEE NLLPKTILYC LNPRDNEVLG 370 380 390 400 410 420 TMIGNFQGEG MPGKMQFGSG WWFNDQKDGM ERQMTQLAQL GLLSRFVGML TDSRSFLSYT 430 440 450 460 470 RHEYFRRILC QMIGRWVEAG EAPADINLLG EMVKNICFNN ARDYFAIELN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mizobuchi K. Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux." Shimada T., Yamamoto K., Ishihama A. J. Bacteriol. 191:4562-4571(2009) [PubMed] [Europe PMC] [Abstract] Cited for: OPERON STRUCTURE, INDUCTION. Strain: K12 / BW25113.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13328 Genomic DNA. Translation: BAA02587.1. U18997 Genomic DNA. Translation: AAA57896.1. Frameshift. U18997 Genomic DNA. Translation: AAA57895.1. Frameshift. U18997 Genomic DNA. Translation: AAA57894.1. Frameshift. U00096 Genomic DNA. Translation: AAC76127.1. AP009048 Genomic DNA. Translation: BAE77142.1.
PIR	A65098.
RefSeq	NP_417563.1. NC_000913.2. YP_491283.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P0A8G3.
SMR	P0A8G3. Positions 4-468.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0A8G3. 9 interactions.
STRING	511145.b3092.
Proteomic databases
PaxDb	P0A8G3.
PRIDE	P0A8G3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC76127; AAC76127; b3092. BAE77142; BAE77142; BAE77142.
GeneID	12933414. 947599.
KEGG	ecj:Y75_p3017. eco:b3092.
PATRIC	32121602. VBIEscCol129921_3187.
Organism-specific databases
EchoBASE	EB2593.
EcoGene	EG12737. uxaC.
Phylogenomic databases
eggNOG	COG1904.
KO	K01812.
OMA	GNPIYHW.
ProtClustDB	PRK02925.
Enzyme and pathway databases
BioCyc	EcoCyc:UXAC-MONOMER. ECOL316407:JW3063-MONOMER. MetaCyc:UXAC-MONOMER.
BRENDA	5.3.1.12. 2026.
UniPathway	UPA00246.
Gene expression databases
Genevestigator	P0A8G3.
Family and domain databases
Gene3D	1.10.2020.10. 1 hit.
HAMAP	MF_00675. UxaC.
InterPro	IPR003766. Uronate_isomerase. IPR023177. Uronate_isomerase_dom2. [Graphical view]
Pfam	PF02614. UxaC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UXAC_ECOLI

Accession

Primary (citable) accession number: P0A8G3
Secondary accession number(s): P42605 , P42606, P42607, P76662, P76663, P76664, Q2M9B4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program