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Protein

UvrABC system protein C

Gene

uvrC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: GO_Central
  • nucleotide-excision repair Source: InterPro
  • response to radiation Source: EcoCyc
  • SOS response Source: UniProtKB-KW

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciEcoCyc:EG11063-MONOMER
MetaCyc:EG11063-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein C
Short name:
Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene namesi
Name:uvrC
Ordered Locus Names:b1913, JW1898
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11063 uvrC

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • excinuclease repair complex Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi42R → A: Defective in 3' incision but not in 5' incision. 1 Publication1
Mutagenesisi399D → A or N: Defective in 5' incision but not in 3' incision. 1 Publication1
Mutagenesisi438D → A or N: Defective in 5' incision but not in 3' incision. 1 Publication1
Mutagenesisi466D → A or N: Defective in 5' incision but not in 3' incision. 1 Publication1
Mutagenesisi538H → F or Y: Defective in 5' incision but not in 3' incision. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001383001 – 610UvrABC system protein CAdd BLAST610

Proteomic databases

EPDiP0A8G0
PaxDbiP0A8G0
PRIDEiP0A8G0

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.

Protein-protein interaction databases

BioGridi4260379, 105 interactors
DIPiDIP-47875N
IntActiP0A8G0, 47 interactors
STRINGi316385.ECDH10B_2054

Structurei

Secondary structure

1610
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi557 – 560Combined sources4
Beta strandi565 – 567Combined sources3
Helixi568 – 576Combined sources9
Helixi579 – 584Combined sources6
Helixi587 – 590Combined sources4
Beta strandi593 – 595Combined sources3
Helixi599 – 608Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KFTNMR-A554-610[»]
ProteinModelPortaliP0A8G0
SMRiP0A8G0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A8G0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 94GIY-YIGAdd BLAST79
Domaini204 – 239UVRAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.Curated

Phylogenomic databases

eggNOGiENOG4105CII Bacteria
COG0322 LUCA
HOGENOMiHOG000279961
InParanoidiP0A8G0
KOiK03703
OMAiLFPIRQC
PhylomeDBiP0A8G0

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203 UvrC, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004791 UvrC
IPR001162 UvrC_homol_region
IPR038476 UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF02151 UVR, 1 hit
PF08459 UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SM00278 HhH1, 2 hits
SUPFAMiSSF46600 SSF46600, 1 hit
SSF47781 SSF47781, 1 hit
SSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR00194 uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit
PS50151 UVR, 1 hit
PS50165 UVRC, 1 hit

Sequencei

Sequence statusi: Complete.

P0A8G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQFDAKAF LKTVTSQPGV YRMYDAGGTV IYVGKAKDLK KRLSSYFRSN
60 70 80 90 100
LASRKTEALV AQIQQIDVTV THTETEALLL EHNYIKLYQP RYNVLLRDDK
110 120 130 140 150
SYPFIFLSGD THPRLAMHRG AKHAKGEYFG PFPNGYAVRE TLALLQKIFP
160 170 180 190 200
IRQCENSVYR NRSRPCLQYQ IGRCLGPCVE GLVSEEEYAQ QVEYVRLFLS
210 220 230 240 250
GKDDQVLTQL ISRMETASQN LEFEEAARIR DQIQAVRRVT EKQFVSNTGD
260 270 280 290 300
DLDVIGVAFD AGMACVHVLF IRQGKVLGSR SYFPKVPGGT ELSEVVETFV
310 320 330 340 350
GQFYLQGSQM RTLPGEILLD FNLSDKTLLA DSLSELAGRK INVQTKPRGD
360 370 380 390 400
RARYLKLART NAATALTSKL SQQSTVHQRL TALASVLKLP EVKRMECFDI
410 420 430 440 450
SHTMGEQTVA SCVVFDANGP LRAEYRRYNI TGITPGDDYA AMNQVLRRRY
460 470 480 490 500
GKAIDDSKIP DVILIDGGKG QLAQAKNVFA ELDVSWDKNH PLLLGVAKGA
510 520 530 540 550
DRKAGLETLF FEPEGEGFSL PPDSPALHVI QHIRDESHDH AIGGHRKKRA
560 570 580 590 600
KVKNTSSLET IEGVGPKRRQ MLLKYMGGLQ GLRNASVEEI AKVPGISQGL
610
AEKIFWSLKH
Length:610
Mass (Da):68,188
Last modified:June 7, 2005 - v1
Checksum:iF76766477C9ABCB6
GO

Sequence cautioni

The sequence CAA27329 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291E → K (PubMed:6330676).Curated1
Sequence conflicti291E → K (PubMed:3515318).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03691 Genomic DNA Translation: CAA27329.1 Different initiation.
U00096 Genomic DNA Translation: AAC74980.2
AP009048 Genomic DNA Translation: BAA15733.1
M24615 Genomic DNA Translation: AAA24756.1
X05398 Genomic DNA Translation: CAA28983.1
M12299 Genomic DNA Translation: AAA98753.1
PIRiF64954 BVECUC
RefSeqiNP_416423.4, NC_000913.3
WP_001283421.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74980; AAC74980; b1913
BAA15733; BAA15733; BAA15733
GeneIDi947203
KEGGiecj:JW1898
eco:b1913
PATRICifig|1411691.4.peg.337

Similar proteinsi

Entry informationi

Entry nameiUVRC_ECOLI
AccessioniPrimary (citable) accession number: P0A8G0
Secondary accession number(s): P07028, P76311, Q8XBD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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