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Protein

Transcriptional repressor NrdR

Gene

nrdR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Represses transcription of the class Ib RNR genes nrdHIEF but has much smaller effect on transcription of the class Ia RNR genes nrdAB and class III RNR genes nrdDG. By binding to nrdR boxes in the promoter regions to alter promoter activity, nrdR differentially regulates nrdAB, nrdHIEF and nrdD transcription in aerobic growth.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3 – 3432By similarityAdd
BLAST

GO - Molecular functioni

  • ATP binding Source: EcoCyc
  • double-stranded DNA binding Source: EcoCyc
  • zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG11320-MONOMER.
ECOL316407:JW0403-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor NrdR
Gene namesi
Name:nrdR
Synonyms:ybaD
Ordered Locus Names:b0413, JW0403
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11320. nrdR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Transcriptional repressor NrdRPRO_0000182296Add
BLAST

Proteomic databases

PaxDbiP0A8D0.
PRIDEiP0A8D0.

Interactioni

Protein-protein interaction databases

BioGridi4259833. 13 interactions.
DIPiDIP-31842N.
IntActiP0A8D0. 18 interactions.
MINTiMINT-1276184.
STRINGi511145.b0413.

Structurei

3D structure databases

ProteinModelPortaliP0A8D0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 13991ATP-coneAdd
BLAST

Sequence similaritiesi

Belongs to the NrdR family.Curated
Contains 1 ATP-cone domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3 – 3432By similarityAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4108Z11. Bacteria.
COG1327. LUCA.
HOGENOMiHOG000097653.
InParanoidiP0A8D0.
KOiK07738.
OMAiRFTTYET.
PhylomeDBiP0A8D0.

Family and domain databases

HAMAPiMF_00440. NrdR. 1 hit.
InterProiIPR005144. ATP-cone_dom.
IPR003796. RNR_NrdR-like.
[Graphical view]
PfamiPF03477. ATP-cone. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00244. TIGR00244. 1 hit.
PROSITEiPS51161. ATP_CONE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A8D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCPFCFAVD TKVIDSRLVG EGSSVRRRRQ CLVCNERFTT FEVAELVMPR
60 70 80 90 100
VVKSNDVREP FNEEKLRSGM LRALEKRPVS SDDVEMAINH IKSQLRATGE
110 120 130 140
REVPSKMIGN LVMEQLKKLD KVAYIRFASV YRSFEDIKEF GEEIARLED
Length:149
Mass (Da):17,229
Last modified:June 7, 2005 - v1
Checksum:iEFF99DD555EF2D26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64395 Genomic DNA. Translation: CAA45734.1.
AM076828 Genomic DNA. Translation: CAJ28592.1.
U82664 Genomic DNA. Translation: AAB40169.1.
U00096 Genomic DNA. Translation: AAC73516.1.
AP009048 Genomic DNA. Translation: BAE76193.1.
PIRiS26200.
RefSeqiNP_414947.1. NC_000913.3.
WP_000543535.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73516; AAC73516; b0413.
BAE76193; BAE76193; BAE76193.
GeneIDi947437.
KEGGiecj:JW0403.
eco:b0413.
PATRICi32115975. VBIEscCol129921_0429.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64395 Genomic DNA. Translation: CAA45734.1.
AM076828 Genomic DNA. Translation: CAJ28592.1.
U82664 Genomic DNA. Translation: AAB40169.1.
U00096 Genomic DNA. Translation: AAC73516.1.
AP009048 Genomic DNA. Translation: BAE76193.1.
PIRiS26200.
RefSeqiNP_414947.1. NC_000913.3.
WP_000543535.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0A8D0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259833. 13 interactions.
DIPiDIP-31842N.
IntActiP0A8D0. 18 interactions.
MINTiMINT-1276184.
STRINGi511145.b0413.

Proteomic databases

PaxDbiP0A8D0.
PRIDEiP0A8D0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73516; AAC73516; b0413.
BAE76193; BAE76193; BAE76193.
GeneIDi947437.
KEGGiecj:JW0403.
eco:b0413.
PATRICi32115975. VBIEscCol129921_0429.

Organism-specific databases

EchoBASEiEB1296.
EcoGeneiEG11320. nrdR.

Phylogenomic databases

eggNOGiENOG4108Z11. Bacteria.
COG1327. LUCA.
HOGENOMiHOG000097653.
InParanoidiP0A8D0.
KOiK07738.
OMAiRFTTYET.
PhylomeDBiP0A8D0.

Enzyme and pathway databases

BioCyciEcoCyc:EG11320-MONOMER.
ECOL316407:JW0403-MONOMER.

Miscellaneous databases

PROiP0A8D0.

Family and domain databases

HAMAPiMF_00440. NrdR. 1 hit.
InterProiIPR005144. ATP-cone_dom.
IPR003796. RNR_NrdR-like.
[Graphical view]
PfamiPF03477. ATP-cone. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00244. TIGR00244. 1 hit.
PROSITEiPS51161. ATP_CONE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRDR_ECOLI
AccessioniPrimary (citable) accession number: P0A8D0
Secondary accession number(s): P25538, Q2MC13, Q3ZUB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.