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Protein

Transcriptional repressor NrdR

Gene

nrdR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Represses transcription of the class Ib RNR genes nrdHIEF but has much smaller effect on transcription of the class Ia RNR genes nrdAB and class III RNR genes nrdDG. By binding to nrdR boxes in the promoter regions to alter promoter activity, nrdR differentially regulates nrdAB, nrdHIEF and nrdD transcription in aerobic growth.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3 – 34By similarityAdd BLAST32

GO - Molecular functioni

  • ATP binding Source: EcoCyc
  • double-stranded DNA binding Source: EcoCyc
  • zinc ion binding Source: InterPro

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:EG11320-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor NrdR
Gene namesi
Name:nrdR
Synonyms:ybaD
Ordered Locus Names:b0413, JW0403
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11320 nrdR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001822961 – 149Transcriptional repressor NrdRAdd BLAST149

Proteomic databases

PaxDbiP0A8D0
PRIDEiP0A8D0

Interactioni

Protein-protein interaction databases

BioGridi4259833, 28 interactors
DIPiDIP-31842N
IntActiP0A8D0, 18 interactors
STRINGi316385.ECDH10B_0369

Structurei

3D structure databases

ProteinModelPortaliP0A8D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 139ATP-coneAdd BLAST91

Sequence similaritiesi

Belongs to the NrdR family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3 – 34By similarityAdd BLAST32

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4108Z11 Bacteria
COG1327 LUCA
HOGENOMiHOG000097653
InParanoidiP0A8D0
KOiK07738
OMAiRFTTYET
PhylomeDBiP0A8D0

Family and domain databases

HAMAPiMF_00440 NrdR, 1 hit
InterProiView protein in InterPro
IPR005144 ATP-cone_dom
IPR003796 RNR_NrdR-like
PANTHERiPTHR30455 PTHR30455, 1 hit
PfamiView protein in Pfam
PF03477 ATP-cone, 1 hit
TIGRFAMsiTIGR00244 TIGR00244, 1 hit
PROSITEiView protein in PROSITE
PS51161 ATP_CONE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A8D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCPFCFAVD TKVIDSRLVG EGSSVRRRRQ CLVCNERFTT FEVAELVMPR
60 70 80 90 100
VVKSNDVREP FNEEKLRSGM LRALEKRPVS SDDVEMAINH IKSQLRATGE
110 120 130 140
REVPSKMIGN LVMEQLKKLD KVAYIRFASV YRSFEDIKEF GEEIARLED
Length:149
Mass (Da):17,229
Last modified:June 7, 2005 - v1
Checksum:iEFF99DD555EF2D26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64395 Genomic DNA Translation: CAA45734.1
AM076828 Genomic DNA Translation: CAJ28592.1
U82664 Genomic DNA Translation: AAB40169.1
U00096 Genomic DNA Translation: AAC73516.1
AP009048 Genomic DNA Translation: BAE76193.1
PIRiS26200
RefSeqiNP_414947.1, NC_000913.3
WP_000543535.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73516; AAC73516; b0413
BAE76193; BAE76193; BAE76193
GeneIDi947437
KEGGiecj:JW0403
eco:b0413
PATRICifig|511145.12.peg.429

Similar proteinsi

Entry informationi

Entry nameiNRDR_ECOLI
AccessioniPrimary (citable) accession number: P0A8D0
Secondary accession number(s): P25538, Q2MC13, Q3ZUB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health